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Volumn 1217, Issue 42, 2010, Pages 6496-6502
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Separation of post-translational modifications in monoclonal antibodies by exploiting subtle conformational changes under mildly acidic conditions
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Author keywords
Antibody; Cation exchange HPLC; Glycosylation; Low pH conformation; Methionine oxidation
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Indexed keywords
ACIDIC CONDITIONS;
CATION EXCHANGE CHROMATOGRAPHY;
CATION-EXCHANGE HPLC;
CHROMATOGRAPHIC SEPARATIONS;
CONFORMATIONAL CHANGE;
FUNCTIONAL CHARACTERIZATION;
LOW-PH CONFORMATION;
METHIONINE OXIDATION;
POST-TRANSLATIONAL MODIFICATIONS;
PROTEIN VARIANTS;
STRUCTURAL CHANGE;
ALLERGIES;
CHEMICAL MODIFICATION;
ESTERIFICATION;
GLYCOSYLATION;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
JOINTS (STRUCTURAL COMPONENTS);
MONOCLONAL ANTIBODIES;
OXIDATION;
PH;
POSITIVE IONS;
PROTEINS;
SURFACE PLASMON RESONANCE;
CONFORMATIONS;
IMMUNOGLOBULIN FC FRAGMENT;
IMMUNOGLOBULIN G ANTIBODY;
MONOCLONAL ANTIBODY;
PROTEIN A;
ACIDITY;
ARTICLE;
CIRCULAR DICHROISM;
CONFORMATIONAL TRANSITION;
CONTROLLED STUDY;
DEGLYCOSYLATION;
DIFFERENTIAL SCANNING CALORIMETRY;
ION EXCHANGE CHROMATOGRAPHY;
METHIONINE OXIDATION;
MOLECULAR STABILITY;
OXIDATION;
PRIORITY JOURNAL;
PROTEIN DOMAIN;
PROTEIN FOLDING;
PROTEIN GLYCOSYLATION;
PROTEIN PROCESSING;
THERMOSTABILITY;
ANTIBODIES, MONOCLONAL;
CALORIMETRY, DIFFERENTIAL SCANNING;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
CHROMATOGRAPHY, ION EXCHANGE;
CIRCULAR DICHROISM;
GLYCOSYLATION;
HUMANS;
HYDROGEN-ION CONCENTRATION;
METHIONINE;
MODELS, MOLECULAR;
OXIDATION-REDUCTION;
PEPTIDE MAPPING;
PROTEIN CONFORMATION;
PROTEIN DENATURATION;
PROTEIN PROCESSING, POST-TRANSLATIONAL;
SPECTROPHOTOMETRY, ULTRAVIOLET;
TEMPERATURE;
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EID: 77957019246
PISSN: 00219673
EISSN: None
Source Type: Journal
DOI: 10.1016/j.chroma.2010.08.044 Document Type: Article |
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Times cited : (32)
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References (25)
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