A new approach to investigating the relationship between productive infection and cytopathicity in vivo

Nature Medicine

Volumn 3, Issue 2, 1997, Pages 218-221

  Reinhart, Todd A ^a   Rogan, Michael J ^a   Viglianti, Gregory A ^b   Rausch, Dianne M ^c   Eiden, Lee E ^c   Haase, Ashley T ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS RNA;

ARTICLE; CYTOPATHOLOGY; DENDRITIC CELL; HUMAN IMMUNODEFICIENCY VIRUS; PRIORITY JOURNAL; RNA SPLICING; SIMIAN IMMUNODEFICIENCY VIRUS; T LYMPHOCYTE; VIRUS INFECTION;

ANIMALS; CYTOPATHOGENIC EFFECT, VIRAL; DENDRITIC CELLS; IN SITU HYBRIDIZATION; MACACA MULATTA; RNA SPLICING; RNA, VIRAL; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS;

HUMAN IMMUNODEFICIENCY VIRUS; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0031052276     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0297-218     Document Type: Article

References (26)

1. Schuurman, H.-J. et al. Lymphocyte status of lymph node and blood in acquired immunodeficiency syndrome (AIDS) and AIDS-related complex disease. J. Pathol. 147, 269-280 (1985).
2. Diebold, J. et al. Lymph node modification in patients with the acquired immunodeficiency syndrome (AIDS) or with AIDS related complex (ARC). Pathol. Res. Pract. 180, 590-611 (1985).
3. Klaus, G.G.B., Humphrey, J.H., Kunkl, A. & Dongworth, D.W. The follicular dendritic cell: Its role in antigen presentation in the generation of immunological memory. Immunol. Rev. 53, 3-18 (1980).
4. Mandel, T.E., Phipps, R.P., Abbot, A. & Tew, J.G. The follicular dendritic cell: Long term antigen retention during immunity. Immunol. Rev. 53, 29-59 (1980).
5. Fox, C.H. et al. Lymphoid germinal centers are reservoirs of human immunodeficiency virus type 1 RNA. J. Infect. Dis. 164, 1051-1057 (1991).
6. Embretson, J.E. et al. Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362, 359-362 (1993).
7. Chakrabarti, L., Cumont, M.-C., Montagnier, L. & Hurtrel, B. Variable course of primary simian immunodeficiency virus infection in lymph nodes: Relation to disease progression. J. Virol. 68, 6634-6642 (1994).
8. + T-helper cells. Am. J. Pathol. 140, 15-22 (1992).
9. Armstrong, J.A. & Horne, R. Follicular dendritic cells and virus-like particles in AIDS-related lymphadenopathy. Lancet 2, 370-372 (1984).
10. Cameron, P.U., Dawkins, R.L., Armstrong, J.A. & Bonifacio, E. Western blot profiles, lymph node ultrastructure and viral expression in HIV-infected patients: A correlative study. Clin. Exp. Immunol. 68, 465-478 (1987).
11. Sprenger, R. et al. Follicular dendritic cells productively infected with immunodeficiency viruses transmit infection to T cells. Med. Microbiol. Immunol. 184, 129-134 (1995).
12. Stahmer, I. et al. SIV infection of monkey spleen cells including follicular dendritic cells in different stages of disease. J. Acquir. Immun. Defic. Syndr. Hum. Retroviruses 11, 1-9 (1996).
13. Parmentier, H.K. et al. HIV-1 infection and virus production in follicular dendritic cells in lymph nodes. Am J. Pathol. 137, 247-251 (1990).
14. Stahmer, I. et al. Isolation of normal human follicular dendritic cells and CD4-independent in vitro infection by human immunodeficiency virus (HIV-1). Eur. J. Immunol. 21, 1873-1878 (1991).
15. Schmitz, J. et al. Follicular dendritic cells retain HIV-1 particles on their plasma membrane, but are not productively infected in asymptomatic patients with follic-ular hyperplasia. J. Immunol. 153, 1352-1359 (1994).
16. Tenner-Racz, K., von Stemm, A.M.R., Gühlk, B., Schmitz, J. & Racz, P. Are follicular dendritic cells, macrophages and interdigitating cells of the lymphoid tissue productively infected by HIV? Res. Virol. 145, 177-182 (1994).
17. Tsunoda, R., Hashimoto, K., Baba, M., Shigeta, S. & Sugai, N. Follicular dendritic cells in vitro are not susceptible to infection by HIV-1. AIDS 10, 595-602 (1996).
18. Murphey-Corb, M. et al. Isolation of a HTLV-III-related retrovirus from macaques with simian AIDS and its possible origin in asymptomatic mangabeys. Nature 321, 435-437 (1986).
19. Murray, E., Rausch, D., Lendvay, J., Sharer, L. & Eiden, L. Cognitive and motor impairments associated with SIV infection in rhesus monkeys. Science 255, 1246-1249 (1992).
20. Rausch, D.M. et al. Cytopathologic and neurochemical correlates of progression to motor/cognitive impairment in SIV-infected rhesus monkeys. I. Neuropathol. Exp. Neurol. 53, 165-175 (1994).
21. Viglianti, G.A., Sharma, P.L. & Mullins, J.I. Simian immunodeficiency virus displays complex patterns of RNA splicing. J. Virol. 64, 4207-4216 (1990).
22. Haase, A.T. et al. Quantitative image analysis of HIV-1 infection in lymphoid tissue. Science 274, 985-989 (1996).
23. Heath, S.L., Tew, J.G., Tew, J.G., Szakal, A.K. & Burton, G.F. Follicular dendritic cells and human immunodeficiency virus infectivity. Nature 377, 740-744 (1995).
24. Peng, H.-R. et al. Single cell transcript analysis of human immunodeficiency virus gene expression in the transition from latent to productive infection. Virology 206, 16-27 (1995).
25. Reinhart, T.A., Rogan, M.J. & Haase, A.T. RNA splice site utilization by simian immunodeficiency viruses derived from sooty mangabey monkeys. Virology 224, 338-344 (1996).
26. Hirsch, V.M., Olmsted, R.A., Murphey-Corb, M., Purcell, R.H. & Johnson, P.R. An African primate lentivirus (SIVsm) closely related to HIV-2. Nature 339, 389 (1989).