Estimating the contribution of the gut to plasma viral load in early SIV infection

Retrovirology

Volumn 10, Issue 1, 2013, Pages

  Petravic, Janka ^a   Vanderford, Thomas H ^b   Silvestri, Guido ^b   Davenport, Miles ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Gut; Immune escape; Simian immunodeficiency virus infection

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; INTESTINE; NONHUMAN; PLASMA; RECTUM BIOPSY; REFERENCE VALUE; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS CELL INTERACTION; VIRUS DETECTION; VIRUS LOAD; VIRUS MUTANT; VIRUS REPLICATION;

ANIMALIA; SIMIAN IMMUNODEFICIENCY VIRUS;

ANIMALS; BIOPSY; GASTROINTESTINAL TRACT; MACACA MULATTA; PLASMA; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VIRAL LOAD; VIRUS REPLICATION;

EID: 84885360358     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-10-105     Document Type: Article

References (19)

1. Li Q, Duan L, Estes JD, Ma Z-M, Rourke T, Wang Y, Reilly C, Carlis J, Miller CJ, Haase AT. Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells. Nature 2005, 434:1148-1152.
2. Mattapallil JJ, Douek DC, Hill B, Nishimura Y, Martin M, Roederer M. Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection. Nature 2005, 434:1093-1097. 10.1038/nature03501, 15793563.
3. Smit-McBride Z, Mattapallil JJ, McChesney M, Ferrick D, Dandekar S. Gastrointestinal T lymphocytes retain high potential for cytokine responses but have severe CD4(+) T-cell depletion at all stages of simian immunodeficiency virus infection compared to peripheral lymphocytes. J Virol 1998, 72:6646-6656. 109855, 9658111.
4. Veazey RS, DeMaria M, Chalifoux LV, Shvetz DE, Pauley DR, Knight HL, Rosenzweig M, Johnson RP, Desrosiers RC, Lackner AA. Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. Science 1998, 280:427-431. 10.1126/science.280.5362.427, 9545219.
5. Brenchley JM, Schacker TW, Ruff LE, Price DA, Taylor JH, Beilman GJ, Nguyen PL, Khoruts A, Larson M, Haase AT, Douek DC. CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med 2004, 200:749-759. 10.1084/jem.20040874, 2211962, 15365096.
6. Anton PA, Elliott J, Poles MA, McGowan IM, Matud J, Hultin LE, Grovit-Ferbas K, Mackay CR, Chen ISY, Giorgi JV. Enhanced levels of functional HIV-1 co-receptors on human mucosal T cells demonstrated using intestinal biopsy tissue. AIDS 2000, 14:1761-1765. 10.1097/00002030-200008180-00011, 10985313.
7. Mowat AM. Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol 2003, 3:331-341. 10.1038/nri1057, 12669023.
8. Mowat AM, Viney JL. The anatomical basis of intestinal immunity. Immunol Rev 1997, 156:145-166. 10.1111/j.1600-065X.1997.tb00966.x, 9176706.
9. Picker LJ. Immunopathogenesis of acute AIDS virus infection. Curr Opin Immunol 2006, 18:399-405. 10.1016/j.coi.2006.05.001, 16753288.
10. Ganusov VV, De Boer RJ. Do most lymphocytes in humans really reside in the gut?. Trends Immunol 2007, 28:514-518. 10.1016/j.it.2007.08.009, 17964854.
11. Lay MDH, Petravic J, Gordon SN, Engram J, Silvestri G, Davenport MP. Is the gut the major source of virus in early simian immunodeficiency virus infection?. J Virol 2009, 83:7517-7523. 10.1128/JVI.00552-09, 2708631, 19458001.
12. Vanderford TH, Bleckwehl C, Engram JC, Dunham RM, Klatt NR, Feinberg MB, Garber DA, Betts MR, Silvestri G. Viral CTL escape mutants are generated in lymph nodes and subsequently become fixed in plasma and rectal mucosa during acute SIV infection of macaques. PLoS Pathog 2011, 7:e1002048. 10.1371/journal.ppat.1002048, 3098234, 21625590.
13. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995, 373:123-126. 10.1038/373123a0, 7816094.
14. Perelson AS, Neumann AU, Markowitz M, Leonard JM, Ho DD. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science 1996, 271:1582-1586. 10.1126/science.271.5255.1582, 8599114.
15. Ramratnam B, Bonhoeffer S, Binley J, Hurley A, Zhang L, Mittler JE, Markowitz M, Moore JP, Perelson AS, Ho DD. Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis. Lancet 1999, 354:1782-1785. 10.1016/S0140-6736(99)02035-8, 10577640.
16. Gordon SN, Cervasi B, Odorizzi P, Silverman R, Aberra F, Ginsberg G, Estes JD, Paiardini M, Frank I, Silvestri G. Disruption of intestinal CD4+ T cell homeostasis is a Key marker of systemic CD4+ T cell activation in HIV-infected individuals. J Immunol 2010, 185:5169-5179. 10.4049/jimmunol.1001801, 3155848, 20889546.
17. Milush JM, Reeves JD, Gordon SN, Zhou D, Muthukumar A, Kosub DA, Chacko E, Giavedoni LD, Ibegbu CC, Cole KS, Miamidian JL, Paiardini M, Barry AP, Staprans SI, Silvestri G, Sodora DL. Virally induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural host. J Immunol 2007, 179:3047-3056.
18. Reeves RK, Rajakumar PA, Evans TI, Connole M, Gillis J, Wong FE, Kuzmichev YV, Carville A, Johnson RP. Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and promote cytotoxic potential in NKp44+ mucosal NK cells during SIV infection. Blood 2011, 118:3321-3330. 10.1182/blood-2011-04-347260, 3179400, 21791421.
19. Kwa S, Kannanganat S, Nigam P, Siddiqui M, Shetty RD, Armstrong W, Ansari A, Bosinger SE, Silvestri G, Amara RR. Plasmacytoid dendritic cells are recruited to the colorectum and contribute to immune activation during pathogenic SIV infection in rhesus macaques. Blood 2011, 118:2763-2773. 10.1182/blood-2011-02-339515, 3172794, 21693759.