Designing cell-targeted therapeutic proteins reveals the interplay between domain connectivity and cell binding

Biophysical Journal

Volumn 107, Issue 10, 2014, Pages 2456-2466

  Robinson Mosher, Avi ^a   Chen, Jan Hung ^b   Way, Jeffrey ^a   Silver, Pamela A ^a,b  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CYTOKINE; DNA; HYBRID PROTEIN; IMMUNOGLOBULIN FRAGMENT; PROTEIN BINDING;

CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; GENETICS; HUMAN; K562 CELL LINE; KINETICS; METABOLISM; PROTEIN ENGINEERING; PROTEIN TERTIARY STRUCTURE;

CYTOKINES; DNA; HUMANS; IMMUNOGLOBULIN FRAGMENTS; INTERFERON-ALPHA; K562 CELLS; KINETICS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS;

EID: 84912144934     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2014.10.007     Document Type: Article

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