Dependence of avidity on linker length for a bivalent ligand-bivalent receptor model system

Journal of the American Chemical Society

Volumn 134, Issue 1, 2012, Pages 333-345

  MacK, Eric T ^a   Snyder, Phillip W ^a   Perez Castillejos, Raquel ^a   Bilgiçer, Başar ^a   Moustakas, Demetri T ^a   Butte, Manish J ^a   Whitesides, George M ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ANALYTICAL ULTRACENTRIFUGATION; BIVALENT LIGANDS; FLUORESCENCE BINDING; MODEL SYSTEM; NON-COVALENT COMPLEXES; RECEPTOR MODEL;

ANTIBODIES; CARBONIC ANHYDRASE; CENTRIFUGATION; STOICHIOMETRY; SULFUR COMPOUNDS;

LIGANDS;

CARBONATE DEHYDRATASE; DIMER; SULFONAMIDE;

ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; STOICHIOMETRY;

CALORIMETRY; CARBONIC ANHYDRASES; ETHOXZOLAMIDE; HUMANS; IMMUNOGLOBULIN G; LIGANDS; MODELS, MOLECULAR; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; SARCOSINE; SULFONAMIDES; THERMODYNAMICS;

EID: 84855655265     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja2073033     Document Type: Article

References (36)

1. Murphy, K., Travers, P., and Walport, M. Janeway's Immunobiology, 7 ed.; Garland Science, Taylor & Francis Group, LLC: New York, 2008.
2. Houk, K. N.; Leach, A. G.; Kim, S. P.; Zhang, X. Y. Angew. Chem., Int. Ed. 2003, 42, 4872
3. Mack, E. T.; Snyder, P. W.; Perez-Castillejos, R.; Whitesides, G. M. J. Am. Chem. Soc. 2011, 133, 11701
4. Gestwicki, J. E.; Cairo, C. W.; Strong, L. E.; Oetjen, K. A.; Kiessling, L. L. J. Am. Chem. Soc. 2002, 124, 14922
5. Mourez, M.; Collier, R. J. Use of Phage Display and Polyvalency to Design Inhibitors of Protein-Protein Interactions; Humana Press Inc.: Totowa, NJ, 2004; Vol. 261.
6. Ernst, B.; Magnani, J. L. Nat. Rev. Drug Discovery 2009, 8, 661
7. Vance, D.; Shah, M.; Joshi, A.; Kane, R. S. Biotechnol. Bioeng. 2008, 101, 429
8. Krishnamurthy, V. M.; Estroff, L. A.; Whitesides, G. M. In Fragment-based Approaches in Drug Discovery; Jahnke, W.; Erlanson, D. A., Eds.; Wiley-VCH: Weinheim, 2006; Vol. 34.
9. Schweitzer-Stenner, R.; Licht, A.; Luescher, I.; Pecht, I. Biochemistry 1987, 26, 3602
10. Das, R.; Diallo, M.; Baird, E.; Coates, G.; GoldStein, B.; Holowka, D.; Baird, B. Biophys. J. 2004, 86, 448A
11. Baird, B.; Posner, R.; Goldstein, B.; Holowka, D. FASEB J. 1991, 5, A652
12. Subramanian, K.; Holowka, D.; Baird, B.; Goldstein, B. Biochemistry 1996, 35, 5518
13. Das, R.; Baird, E.; Allen, S.; Baird, B.; Holowka, D.; Goldstein, B. Biochemistry 2007, 47, 1017
14. Bilgiçer, B.; Moustakas, D. T.; Whitesides, G. M. J. Am. Chem. Soc. 2007, 129, 3722
15. Mammen, M.; Choi, S.-K.; Whitesides, G. M. Angew. Chem., Int. Ed. 1998, 37, 2755
16. Burton, R. E.; Hunt, J. A.; Fierke, C. A.; Oas, T. G. Protein Sci. 2000, 9, 776
17. Christianson, D. W.; Fierke, C. A. Acc. Chem. Res. 1996, 29, 331
18. Krebs, J. F.; Ippolito, J. A.; Christianson, D. W.; Fierke, C. A. J. Biol. Chem. 1993, 268, 27458
19. Nair, S. K.; Calderone, T. L.; Christianson, D. W.; Fierke, C. A. J. Biol. Chem. 1991, 266, 17320
20. Supuran, C. T.; Scozzafava, A.; Casini, A. Med. Res. Rev. 2003, 23, 146
21. Krishnamurthy, V. M.; Kaufman, G. K.; Urbach, A. R.; Gitlin, I.; Gudiksen, K. L.; Weibel, D. B.; Whitesides, G. M. Chem. Rev. 2008, 108, 946
22. Krishnamurthy, V. M.; Semetey, V.; Bracher, P. J.; Shen, N.; Whitesides, G. M. J. Am. Chem. Soc. 2007, 129, 1312
23. Ercolani, G. J. Am. Chem. Soc. 2003, 125, 16097
24. Hunter, C. A.; Anderson, H. L. Angew. Chem., Int. Ed. 2009, 48, 7488
25. Sidido, M.; Kanazawa, Y.; Imanishi, Y. Biopolymers 1981, 20, 653
26. Krishnamurthy, V. M.; Bohall, B. R.; Semetey, V.; Whitesides, G. M. J. Am. Chem. Soc. 2006, 128, 5802
27. Ostuni, E.; Chapman, R. G.; Holmlin, R. E.; Takayama, S.; Whitesides, G. M. Langmuir 2001, 17, 5605
28. Mack, E.; Cummings, L.; Perez-Castillejos, R. Anal. Bioanal. Chem. 2011, 399, 1641
29. Lebowitz, J.; Lewis, M. S.; Schuck, P. Protein Sci. 2002, 11, 2067
30. Chen, R. F.; Kernohan, J. C. J. Biol. Chem. 1967, 242, 5813
31. Dembo, M.; Goldstein, B. J. Immunol. 1978, 121, 345
32. Lundquist, J. J.; Toone, E. J. Chem. Rev. 2002, 102, 555
33. Wiseman, T.; Williston, S.; Brandts, J. F.; Lin, L.-N. Anal. Biochem. 1989, 179, 131
34. Mecinovic, J.; Snyder, P. W.; Mirica, K. A.; Bai, S.; Mack, E. T.; Kwant, R. L.; Moustakas, D. T.; Heroux, A.; Whitesides, G. M. J. Am. Chem. Soc. 2011, 133, 14017-14026
35. Kramer, R. H.; Karpen, J. W. Nature 1998, 395, 710
36. Chan, W. C.; White, P. D. Fmoc solid phase peptide synthesis a practical approach; Oxford University Press: New York, 2000.