메뉴 건너뛰기




Volumn 38, Issue 6, 2014, Pages 765-772

Resveratrol suppresses the proliferation of breast cancer cells by inhibiting fatty acid synthase signaling pathway

Author keywords

Akt; FASN; Her2; PI3K; Resveratrol; SKBR 3

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FATTY ACID SYNTHASE; LIPOCORTIN 5; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RESVERATROL; ANTINEOPLASTIC AGENT; ERBB2 PROTEIN, HUMAN; STILBENE DERIVATIVE;

EID: 84912141641     PISSN: 18777821     EISSN: 1877783X     Source Type: Journal    
DOI: 10.1016/j.canep.2014.09.006     Document Type: Article
Times cited : (68)

References (73)
  • 1
    • 76749107605 scopus 로고    scopus 로고
    • Antioxidative and antigenotoxic properties of vegetables and dietary phytochemicals: the value of genomics biomarkers in molecular epidemiology
    • de Kok T.M., de Waard P., Wilms L.C., van Breda S.G. Antioxidative and antigenotoxic properties of vegetables and dietary phytochemicals: the value of genomics biomarkers in molecular epidemiology. Mol Nutr Food Res 2010, 54:208-217.
    • (2010) Mol Nutr Food Res , vol.54 , pp. 208-217
    • de Kok, T.M.1    de Waard, P.2    Wilms, L.C.3    van Breda, S.G.4
  • 2
    • 0034535518 scopus 로고    scopus 로고
    • Novel approaches to chemoprevention of skin cancer
    • Bickers D.R., Athar M. Novel approaches to chemoprevention of skin cancer. J Dermatol 2000, 27:691-695.
    • (2000) J Dermatol , vol.27 , pp. 691-695
    • Bickers, D.R.1    Athar, M.2
  • 3
    • 0033233393 scopus 로고    scopus 로고
    • Cancer chemoprevention: progress and promise
    • Keloff G.J., Sigman C.C., Greenwald P.P. Cancer chemoprevention: progress and promise. Eur J Cancer 1999, 35:2031-2038.
    • (1999) Eur J Cancer , vol.35 , pp. 2031-2038
    • Keloff, G.J.1    Sigman, C.C.2    Greenwald, P.P.3
  • 4
    • 67650297506 scopus 로고    scopus 로고
    • Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials
    • Bishayee A. Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials. Cancer Prev Res 2009, 2:409-418.
    • (2009) Cancer Prev Res , vol.2 , pp. 409-418
    • Bishayee, A.1
  • 5
    • 51349132313 scopus 로고    scopus 로고
    • Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives
    • Kundu J.K., Surh Y.J. Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives. Cancer Lett 2008, 269:243-261.
    • (2008) Cancer Lett , vol.269 , pp. 243-261
    • Kundu, J.K.1    Surh, Y.J.2
  • 6
    • 0031561513 scopus 로고    scopus 로고
    • Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
    • Jang M., Cai L., Udeani G.O., Slowing K.V., Thomas C.F., Beecher C.W., et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997, 275:218-220.
    • (1997) Science , vol.275 , pp. 218-220
    • Jang, M.1    Cai, L.2    Udeani, G.O.3    Slowing, K.V.4    Thomas, C.F.5    Beecher, C.W.6
  • 7
    • 33646179475 scopus 로고    scopus 로고
    • Chemopreventive effect of trans-resveratrol-a phytoalexin against colonic aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine induced colon carcinogenesis
    • Sengottuvelan M., Viswanathan P., Nalini N. Chemopreventive effect of trans-resveratrol-a phytoalexin against colonic aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine induced colon carcinogenesis. Carcinogenesis 2006, 27:1038-1046.
    • (2006) Carcinogenesis , vol.27 , pp. 1038-1046
    • Sengottuvelan, M.1    Viswanathan, P.2    Nalini, N.3
  • 8
    • 0036425598 scopus 로고    scopus 로고
    • Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis
    • Kapadia G.J., Azuine M.A., Tokuda H., Takasaki M. Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis. Pharmacol Res 2002, 45:499-505.
    • (2002) Pharmacol Res , vol.45 , pp. 499-505
    • Kapadia, G.J.1    Azuine, M.A.2    Tokuda, H.3    Takasaki, M.4
  • 9
    • 78549288940 scopus 로고    scopus 로고
    • Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics and effect on the insulin-like growth factor axis
    • Brown V.A., Patel K.R., Viskaduraki M., et al. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics and effect on the insulin-like growth factor axis. Cancer Res 2010, 70:9003-9011.
    • (2010) Cancer Res , vol.70 , pp. 9003-9011
    • Brown, V.A.1    Patel, K.R.2    Viskaduraki, M.3
  • 10
    • 77957355158 scopus 로고    scopus 로고
    • Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients
    • Patel K.R., Brown V.A., Jones D.J., et al. Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients. Cancer Res 2010, 70:7392-7399.
    • (2010) Cancer Res , vol.70 , pp. 7392-7399
    • Patel, K.R.1    Brown, V.A.2    Jones, D.J.3
  • 11
    • 0036301453 scopus 로고    scopus 로고
    • Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines
    • Joe A.K., Liu H., Suzui M., et al. Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines. Clin Cancer Res 2002, 8:893-903.
    • (2002) Clin Cancer Res , vol.8 , pp. 893-903
    • Joe, A.K.1    Liu, H.2    Suzui, M.3
  • 12
    • 0037457308 scopus 로고    scopus 로고
    • Differential expression of genes induced by resveratrol in LNCaP cells: p53-mediated molecular targets
    • Narayanan B.A., Narayanan N.K., Re G.G., Nixon D.W. Differential expression of genes induced by resveratrol in LNCaP cells: p53-mediated molecular targets. Int J Cancer 2003, 104:204-212.
    • (2003) Int J Cancer , vol.104 , pp. 204-212
    • Narayanan, B.A.1    Narayanan, N.K.2    Re, G.G.3    Nixon, D.W.4
  • 13
    • 0034902229 scopus 로고    scopus 로고
    • Resveratrol causes WAF-1/p21-mediated G1-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells
    • Ahmad N., Adhami V.M., Afaq F., Feyes D.K., Mukhtar H. Resveratrol causes WAF-1/p21-mediated G1-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells. Clin Cancer Res 2001, 7:1466-1473.
    • (2001) Clin Cancer Res , vol.7 , pp. 1466-1473
    • Ahmad, N.1    Adhami, V.M.2    Afaq, F.3    Feyes, D.K.4    Mukhtar, H.5
  • 14
    • 0032856159 scopus 로고    scopus 로고
    • Resveratrol preferentially inhibits protein kinase C-catalyzed phosphorylation of a cofactor-independent, arginine-rich protein substrate by a novel mechanism
    • Stewart J.R., Ward N.E., Ioannides C.G., O'Brien C.A. Resveratrol preferentially inhibits protein kinase C-catalyzed phosphorylation of a cofactor-independent, arginine-rich protein substrate by a novel mechanism. Biochemistry 1999, 38:13244-13251.
    • (1999) Biochemistry , vol.38 , pp. 13244-13251
    • Stewart, J.R.1    Ward, N.E.2    Ioannides, C.G.3    O'Brien, C.A.4
  • 15
    • 0035408191 scopus 로고    scopus 로고
    • Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2
    • Tinhofer I., Bernhard D., Senfter M., et al. Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2. FASEB J 2001, 15:1613-1615.
    • (2001) FASEB J , vol.15 , pp. 1613-1615
    • Tinhofer, I.1    Bernhard, D.2    Senfter, M.3
  • 16
    • 3042714353 scopus 로고    scopus 로고
    • Role of Bax in resveratrol induced apoptosis of colorectal carcinoma cells
    • Mahyar-Roemer M., Kohler H., Roemer K. Role of Bax in resveratrol induced apoptosis of colorectal carcinoma cells. BMC Cancer 2002, 2:27-35.
    • (2002) BMC Cancer , vol.2 , pp. 27-35
    • Mahyar-Roemer, M.1    Kohler, H.2    Roemer, K.3
  • 19
    • 0034695431 scopus 로고    scopus 로고
    • Estrogenic/antiestrogenic and scavenging properties of (E)- and (Z)-resveratrol
    • Basly J.P., Marre-Fournier F., Le-Bail J.C., Habrioux G., Chulia A.J. Estrogenic/antiestrogenic and scavenging properties of (E)- and (Z)-resveratrol. Life Sci 2000, 66:769-777.
    • (2000) Life Sci , vol.66 , pp. 769-777
    • Basly, J.P.1    Marre-Fournier, F.2    Le-Bail, J.C.3    Habrioux, G.4    Chulia, A.J.5
  • 20
    • 3343022920 scopus 로고    scopus 로고
    • Oestrogen inhibits resveratrol-induced post-translational modification of p53 and apoptosis in breast cancer cells
    • Zhang S., Cao H.J., Davis F.B., et al. Oestrogen inhibits resveratrol-induced post-translational modification of p53 and apoptosis in breast cancer cells. Br J Cancer 2004, 91:178-185.
    • (2004) Br J Cancer , vol.91 , pp. 178-185
    • Zhang, S.1    Cao, H.J.2    Davis, F.B.3
  • 21
    • 0034741239 scopus 로고    scopus 로고
    • Resveratrol inhibits human breast cancer cell growth and may mitigate the effect of linoleic acid, a potent breast cancer cell stimulator
    • Nakagawa H., Kiyozuka Y., Uemura Y., et al. Resveratrol inhibits human breast cancer cell growth and may mitigate the effect of linoleic acid, a potent breast cancer cell stimulator. J Cancer Res Clin Oncol 2001, 127:258-264.
    • (2001) J Cancer Res Clin Oncol , vol.127 , pp. 258-264
    • Nakagawa, H.1    Kiyozuka, Y.2    Uemura, Y.3
  • 22
    • 0037039456 scopus 로고    scopus 로고
    • Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides
    • Shimokawa T., Kumar M.V., Lane M.D. Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides. Proc Natl Acad Sci USA 2002, 99:66-71.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 66-71
    • Shimokawa, T.1    Kumar, M.V.2    Lane, M.D.3
  • 23
    • 0034733730 scopus 로고    scopus 로고
    • Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
    • Loftus T.M., Jaworsky D.E., Frehywot G.L., et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 2000, 288:2379-2381.
    • (2000) Science , vol.288 , pp. 2379-2381
    • Loftus, T.M.1    Jaworsky, D.E.2    Frehywot, G.L.3
  • 24
    • 0034724397 scopus 로고    scopus 로고
    • Synthesis and antitumor activity of an inhibitor of fatty acid synthase
    • Kuhajda F.P., Pizer E.S., Li J.N., et al. Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc Natl Acad Sci USA 2000, 97:3450-3454.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 3450-3454
    • Kuhajda, F.P.1    Pizer, E.S.2    Li, J.N.3
  • 25
    • 0031845136 scopus 로고    scopus 로고
    • Nutritional and hormonal regulation of enzymes in fat synthesis: studies of fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription
    • Sul H.S., Wang D. Nutritional and hormonal regulation of enzymes in fat synthesis: studies of fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription. Annu Rev Nutr 1998, 18:331-351.
    • (1998) Annu Rev Nutr , vol.18 , pp. 331-351
    • Sul, H.S.1    Wang, D.2
  • 26
    • 0030706079 scopus 로고    scopus 로고
    • Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma
    • Milgraum L.Z., Witters L.A., Pasternack G.R., Kuhajda F.P. Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. Clin Cancer Res 1997, 3:2115-2120.
    • (1997) Clin Cancer Res , vol.3 , pp. 2115-2120
    • Milgraum, L.Z.1    Witters, L.A.2    Pasternack, G.R.3    Kuhajda, F.P.4
  • 27
    • 33745576142 scopus 로고    scopus 로고
    • Fatty acid synthase (FAS) predictive strength in poorly differentiated early breast carcinomas
    • Alo P.L., Visca P., Trombetta G., et al. Fatty acid synthase (FAS) predictive strength in poorly differentiated early breast carcinomas. Tumori 1999, 85:35-40.
    • (1999) Tumori , vol.85 , pp. 35-40
    • Alo, P.L.1    Visca, P.2    Trombetta, G.3
  • 28
    • 0028301959 scopus 로고
    • Fatty acid synthesis: a potential selective target for antineoplastic therapy
    • Kuhajda F.P., Jenner K., Wood F.D., et al. Fatty acid synthesis: a potential selective target for antineoplastic therapy. Proc Natl Acad Sci USA 1994, 91:6379-6383.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 6379-6383
    • Kuhajda, F.P.1    Jenner, K.2    Wood, F.D.3
  • 29
    • 78149494317 scopus 로고    scopus 로고
    • Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells
    • Jin Q., Yuan L.X., Boulbes D., et al. Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells. Breast Cancer Res 2010, 12:R96.
    • (2010) Breast Cancer Res , vol.12 , pp. R96
    • Jin, Q.1    Yuan, L.X.2    Boulbes, D.3
  • 30
    • 38549147538 scopus 로고    scopus 로고
    • Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells
    • Vazquez-Martin A., Colomer R., Brunet J., Lupu R., Menendez J.A. Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells. Cell Prolif 2008, 41:59-85.
    • (2008) Cell Prolif , vol.41 , pp. 59-85
    • Vazquez-Martin, A.1    Colomer, R.2    Brunet, J.3    Lupu, R.4    Menendez, J.A.5
  • 31
    • 3242685815 scopus 로고    scopus 로고
    • Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells
    • Menendez J.A., Vellon L., Mehmi I., et al. Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. Proc Natl Acad Sci USA 2004, 101:10715-10720.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10715-10720
    • Menendez, J.A.1    Vellon, L.2    Mehmi, I.3
  • 32
    • 37049183697 scopus 로고
    • Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon D.J., Clark G.M., Wong S.G., et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987, 235:177-182.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 33
    • 43749100987 scopus 로고    scopus 로고
    • Fatty acid metabolism in breast cancer cells: differential inhibitory effects of epigallocatechin gallate (EGCG) and C75
    • Puig T., Vázquez-Martín A., Relat J., et al. Fatty acid metabolism in breast cancer cells: differential inhibitory effects of epigallocatechin gallate (EGCG) and C75. Breast Cancer Res Treat 2008, 109:471-479.
    • (2008) Breast Cancer Res Treat , vol.109 , pp. 471-479
    • Puig, T.1    Vázquez-Martín, A.2    Relat, J.3
  • 34
    • 34447295657 scopus 로고    scopus 로고
    • Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen activated protein kinase cascade signaling
    • Pan M.H., Lin C.C., Lin J.K., Chen W.J. Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen activated protein kinase cascade signaling. J Agric Food Chem 2007, 55:5030-5037.
    • (2007) J Agric Food Chem , vol.55 , pp. 5030-5037
    • Pan, M.H.1    Lin, C.C.2    Lin, J.K.3    Chen, W.J.4
  • 35
    • 33646012970 scopus 로고    scopus 로고
    • Inhibition of fatty acid synthase by polyphenols
    • Tian W.X. Inhibition of fatty acid synthase by polyphenols. Curr Med Chem 2006, 13:967-977.
    • (2006) Curr Med Chem , vol.13 , pp. 967-977
    • Tian, W.X.1
  • 36
    • 61349155536 scopus 로고    scopus 로고
    • Resveratrol inhibits fatty acid and triacylglycerol synthesis in rat hepatocytes
    • Gnoni G.V., Paglialonga G. Resveratrol inhibits fatty acid and triacylglycerol synthesis in rat hepatocytes. Eur J Clin Invest 2009, 39:211-218.
    • (2009) Eur J Clin Invest , vol.39 , pp. 211-218
    • Gnoni, G.V.1    Paglialonga, G.2
  • 37
    • 32944475076 scopus 로고    scopus 로고
    • Structure-activity relationship of polyphenols that inhibit fatty acid synthase
    • Li B.H., Ma X.F., Wang Y., Tian W.X. Structure-activity relationship of polyphenols that inhibit fatty acid synthase. J Biochem 2005, 138:679-685.
    • (2005) J Biochem , vol.138 , pp. 679-685
    • Li, B.H.1    Ma, X.F.2    Wang, Y.3    Tian, W.X.4
  • 38
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983, 65:55-63.
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 39
    • 0025726216 scopus 로고
    • A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
    • Nicoletti I., Migliorati G., Pagliacci M.C., Grignani F., Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991, 139:271-279.
    • (1991) J Immunol Methods , vol.139 , pp. 271-279
    • Nicoletti, I.1    Migliorati, G.2    Pagliacci, M.C.3    Grignani, F.4    Riccardi, C.5
  • 40
    • 1642316190 scopus 로고    scopus 로고
    • Imexon-induced apoptosis in multiple myeloma tumor cells is caspase-8 dependent
    • Evens A.M., Prachand S., Shi B., et al. Imexon-induced apoptosis in multiple myeloma tumor cells is caspase-8 dependent. Clin Cancer Res 2004, 10:1481-1491.
    • (2004) Clin Cancer Res , vol.10 , pp. 1481-1491
    • Evens, A.M.1    Prachand, S.2    Shi, B.3
  • 41
    • 34547400441 scopus 로고    scopus 로고
    • Tuftsin augments antitumor efficacy of liposomised etoposide against fibrosarcoma in Swiss albino mice
    • Khan A., Aijaz A.K., Dwivedi V., et al. Tuftsin augments antitumor efficacy of liposomised etoposide against fibrosarcoma in Swiss albino mice. Mol Med 2007, 13:266-276.
    • (2007) Mol Med , vol.13 , pp. 266-276
    • Khan, A.1    Aijaz, A.K.2    Dwivedi, V.3
  • 42
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
    • Chou T.C., Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984, 22:27-55.
    • (1984) Adv Enzyme Regul , vol.22 , pp. 27-55
    • Chou, T.C.1    Talalay, P.2
  • 43
    • 2442561553 scopus 로고    scopus 로고
    • Apoptosis as a novel target for cancer chemoprevention
    • Sun S.Y., Hail N., Lotan R. Apoptosis as a novel target for cancer chemoprevention. J Natl Cancer Inst 2004, 96:662-672.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 662-672
    • Sun, S.Y.1    Hail, N.2    Lotan, R.3
  • 44
    • 0032881288 scopus 로고    scopus 로고
    • AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation
    • Chan T.O., Rittenhouse S.E., Tsichlis P.N. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Annu Rev Biochem 1999, 68:965-1041.
    • (1999) Annu Rev Biochem , vol.68 , pp. 965-1041
    • Chan, T.O.1    Rittenhouse, S.E.2    Tsichlis, P.N.3
  • 45
    • 33845970575 scopus 로고    scopus 로고
    • Resveratrol regulation of PI3KAKT signaling pathway genes in MDA-MB-231 breast cancer cells
    • Rachid O., Alkhalaf M. Resveratrol regulation of PI3KAKT signaling pathway genes in MDA-MB-231 breast cancer cells. Cancer Genomics Proteomics 2006, 3:383-388.
    • (2006) Cancer Genomics Proteomics , vol.3 , pp. 383-388
    • Rachid, O.1    Alkhalaf, M.2
  • 46
    • 19544365109 scopus 로고    scopus 로고
    • Inhibition of the respiratory burst by resveratrol in human monocytes: correlation with inhibition of PI3K signalling
    • Poolman T.M., Ng L.L., Farmer P.B., Manson M.M. Inhibition of the respiratory burst by resveratrol in human monocytes: correlation with inhibition of PI3K signalling. Free Radic Biol Med 2005, 39:118-132.
    • (2005) Free Radic Biol Med , vol.39 , pp. 118-132
    • Poolman, T.M.1    Ng, L.L.2    Farmer, P.B.3    Manson, M.M.4
  • 47
    • 27844445642 scopus 로고    scopus 로고
    • Perturbations of the AKT signaling pathway in human cancer
    • Altomare D.A., Testa J.R. Perturbations of the AKT signaling pathway in human cancer. Oncogene 2005, 24:7455-7464.
    • (2005) Oncogene , vol.24 , pp. 7455-7464
    • Altomare, D.A.1    Testa, J.R.2
  • 48
    • 0034477047 scopus 로고    scopus 로고
    • Transcriptional targeting of the HER2/neu oncogene
    • Wang S.C., Hung M.C. Transcriptional targeting of the HER2/neu oncogene. Drugs Today (Barc) 2000, 36:835-843.
    • (2000) Drugs Today (Barc) , vol.36 , pp. 835-843
    • Wang, S.C.1    Hung, M.C.2
  • 49
    • 0032509239 scopus 로고    scopus 로고
    • Importance of poly(ADPribose) polymerase and its cleavage in apoptosis: lesson from an uncleavable mutant
    • Oliver F.J., de la Rubia G., Rolli V., et al. Importance of poly(ADPribose) polymerase and its cleavage in apoptosis: lesson from an uncleavable mutant. J Biol Chem 1998, 273:33533-33539.
    • (1998) J Biol Chem , vol.273 , pp. 33533-33539
    • Oliver, F.J.1    de la Rubia, G.2    Rolli, V.3
  • 50
    • 0037089564 scopus 로고    scopus 로고
    • Rate-limiting effects of Cyclin D1 in transformation by ErbB2 predicts synergy between herceptin and flavopiridol
    • Nahta R., Iglehart D., Kempkes B., Schmidt E.V. Rate-limiting effects of Cyclin D1 in transformation by ErbB2 predicts synergy between herceptin and flavopiridol. Cancer Res 2002, 62:2267-2271.
    • (2002) Cancer Res , vol.62 , pp. 2267-2271
    • Nahta, R.1    Iglehart, D.2    Kempkes, B.3    Schmidt, E.V.4
  • 51
    • 0035963435 scopus 로고    scopus 로고
    • Specific protection against breast cancers by cyclin D1 ablation
    • Yu Q., Gen Y., Sicinski P. Specific protection against breast cancers by cyclin D1 ablation. Nature 2001, 411:1017-1021.
    • (2001) Nature , vol.411 , pp. 1017-1021
    • Yu, Q.1    Gen, Y.2    Sicinski, P.3
  • 52
    • 0035866404 scopus 로고    scopus 로고
    • Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase
    • She Q.B., Bode A.M., Ma W.Y., Chen V., Dong Z. Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. Cancer Res 2001, 61:1604-1610.
    • (2001) Cancer Res , vol.61 , pp. 1604-1610
    • She, Q.B.1    Bode, A.M.2    Ma, W.Y.3    Chen, V.4    Dong, Z.5
  • 53
    • 0033042331 scopus 로고    scopus 로고
    • Resveratrol, an antioxidant present in red wine, induces apoptosis in human promyelocytic leukemia (HL-60) cells
    • Surh Y.J., Hurh Y.J., Kang J.Y., et al. Resveratrol, an antioxidant present in red wine, induces apoptosis in human promyelocytic leukemia (HL-60) cells. Cancer Lett 1999, 140:1-10.
    • (1999) Cancer Lett , vol.140 , pp. 1-10
    • Surh, Y.J.1    Hurh, Y.J.2    Kang, J.Y.3
  • 54
    • 0345566753 scopus 로고    scopus 로고
    • Chemopreventive agent resveratrol, a natural product derived from grapes triggers Cd95 signalling-dependent apoptosis in human tumor cells
    • Clement M.V., Hirpara J.L., Pervaiz S. Chemopreventive agent resveratrol, a natural product derived from grapes triggers Cd95 signalling-dependent apoptosis in human tumor cells. Blood 1998, 92:996-1002.
    • (1998) Blood , vol.92 , pp. 996-1002
    • Clement, M.V.1    Hirpara, J.L.2    Pervaiz, S.3
  • 55
  • 56
    • 33646430295 scopus 로고    scopus 로고
    • Growth inhibition and apoptosis in human Philadelphia chromosome-positive lymphoblastic leukemia cell lines by treatment with the dual PPARalpha/gamma ligand TZD18
    • Liu H., Zang C., Fenner M.H., et al. Growth inhibition and apoptosis in human Philadelphia chromosome-positive lymphoblastic leukemia cell lines by treatment with the dual PPARalpha/gamma ligand TZD18. Blood 2006, 107:3683-3692.
    • (2006) Blood , vol.107 , pp. 3683-3692
    • Liu, H.1    Zang, C.2    Fenner, M.H.3
  • 57
    • 57749170979 scopus 로고    scopus 로고
    • Chemopreventive potential of resveratrol in mouse skin tumors through regulation of mitochondrial and PI3K/AKT signaling pathways
    • Roy P., Kalra N., Prasad S., George J., Shukla Y. Chemopreventive potential of resveratrol in mouse skin tumors through regulation of mitochondrial and PI3K/AKT signaling pathways. Pharm Res 2009, 26:211-217.
    • (2009) Pharm Res , vol.26 , pp. 211-217
    • Roy, P.1    Kalra, N.2    Prasad, S.3    George, J.4    Shukla, Y.5
  • 58
    • 58349100590 scopus 로고    scopus 로고
    • Suppression of prostate cancer growth by resveratrol in the transgenic rat for adenocarcinoma of prostate (TRAP) model
    • Seeni A., Takahashi S., Takeshita K., et al. Suppression of prostate cancer growth by resveratrol in the transgenic rat for adenocarcinoma of prostate (TRAP) model. Asian Pac J Cancer Prev 2008, 9:7-14.
    • (2008) Asian Pac J Cancer Prev , vol.9 , pp. 7-14
    • Seeni, A.1    Takahashi, S.2    Takeshita, K.3
  • 59
    • 0035845638 scopus 로고    scopus 로고
    • Mapping the functional topology of the animal fatty acid synthase by mutant complementation in vitro
    • Rangan V.S., Joshi A.K., Smith S. Mapping the functional topology of the animal fatty acid synthase by mutant complementation in vitro. Biochemistry 2001, 40:10792-10799.
    • (2001) Biochemistry , vol.40 , pp. 10792-10799
    • Rangan, V.S.1    Joshi, A.K.2    Smith, S.3
  • 60
    • 0035853039 scopus 로고    scopus 로고
    • Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimmer
    • Chirala S.S., Jayakumar A., Gu Z.W., Wakil S.J. Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimmer. Proc Natl Acad Sci USA 2001, 98:3104-3108.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3104-3108
    • Chirala, S.S.1    Jayakumar, A.2    Gu, Z.W.3    Wakil, S.J.4
  • 61
    • 0031050460 scopus 로고    scopus 로고
    • Mapping of functional interactions between domains of the animal fatty acid synthase by mutant complementation in vitro
    • Joshi A.K., Witkowski A., Smith S. Mapping of functional interactions between domains of the animal fatty acid synthase by mutant complementation in vitro. Biochemistry 1997, 36:2316-2322.
    • (1997) Biochemistry , vol.36 , pp. 2316-2322
    • Joshi, A.K.1    Witkowski, A.2    Smith, S.3
  • 62
    • 4043059294 scopus 로고    scopus 로고
    • Fatty acid synthase as a tumor marker: its extracellular expression in human breast cancer
    • Wang Y.Y., Kuhajda F.P., Li J., et al. Fatty acid synthase as a tumor marker: its extracellular expression in human breast cancer. J Exp Ther Oncol 2004, 4:101-110.
    • (2004) J Exp Ther Oncol , vol.4 , pp. 101-110
    • Wang, Y.Y.1    Kuhajda, F.P.2    Li, J.3
  • 63
    • 0034959513 scopus 로고    scopus 로고
    • Immunohistochemical expression of human erythrocyte glucose transporter and fatty acid synthase in infiltrating breast carcinomas and adjacent typical/atypical hyperplastic or normal breast tissue
    • Alo P.L., Visca P., Botti C., et al. Immunohistochemical expression of human erythrocyte glucose transporter and fatty acid synthase in infiltrating breast carcinomas and adjacent typical/atypical hyperplastic or normal breast tissue. Am J Clin Pathol 2001, 116:129-134.
    • (2001) Am J Clin Pathol , vol.116 , pp. 129-134
    • Alo, P.L.1    Visca, P.2    Botti, C.3
  • 64
    • 57349175482 scopus 로고    scopus 로고
    • Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model
    • Carvalho M.A., Zecchin K.G., Seguin F., et al. Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model. Int J Cancer 2008, 123:2557-2565.
    • (2008) Int J Cancer , vol.123 , pp. 2557-2565
    • Carvalho, M.A.1    Zecchin, K.G.2    Seguin, F.3
  • 65
    • 68349089406 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma protects ERBB2-positive breast cancer cells from palmitate toxicity
    • Kourtidis A., Srinivasaiah R., Carkner R.D., Brosnan M.J., Conklin D.S. Peroxisome proliferator-activated receptor-gamma protects ERBB2-positive breast cancer cells from palmitate toxicity. Breast Cancer Res 2009, 11:R16.
    • (2009) Breast Cancer Res , vol.11 , pp. R16
    • Kourtidis, A.1    Srinivasaiah, R.2    Carkner, R.D.3    Brosnan, M.J.4    Conklin, D.S.5
  • 66
    • 34548814981 scopus 로고    scopus 로고
    • Upregulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells
    • Yoon S., Lee M.Y., Park S.W., et al. Upregulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells. J Biol Chem 2007, 282:26122-26131.
    • (2007) J Biol Chem , vol.282 , pp. 26122-26131
    • Yoon, S.1    Lee, M.Y.2    Park, S.W.3
  • 67
  • 68
    • 76049105429 scopus 로고    scopus 로고
    • Fine-tuning the lipogenic/lipolytic balance to optimize the metabolic requirements of cancer cell growth: molecular mechanisms and therapeutic perspectives
    • Menendez J.A. Fine-tuning the lipogenic/lipolytic balance to optimize the metabolic requirements of cancer cell growth: molecular mechanisms and therapeutic perspectives. Biochim Biophys Acta 2010, 1801:381-391.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 381-391
    • Menendez, J.A.1
  • 69
    • 30444434391 scopus 로고    scopus 로고
    • Targeting fatty acid synthase: potential for therapeutic intervention in her-2/neu-overexpressing breast cancer
    • Menendez J.A., Lupu R., Colomer R. Targeting fatty acid synthase: potential for therapeutic intervention in her-2/neu-overexpressing breast cancer. Drug News Perspect 2005, 18:375-385.
    • (2005) Drug News Perspect , vol.18 , pp. 375-385
    • Menendez, J.A.1    Lupu, R.2    Colomer, R.3
  • 70
    • 15244355117 scopus 로고    scopus 로고
    • Targeting fatty acid synthase-driven lipid rafts: a novel strategy to overcome trastuzumab resistance in breast cancer cells
    • Menendez J.A., Vellon L., Lupu R. Targeting fatty acid synthase-driven lipid rafts: a novel strategy to overcome trastuzumab resistance in breast cancer cells. Med Hypotheses 2005, 64:997-1001.
    • (2005) Med Hypotheses , vol.64 , pp. 997-1001
    • Menendez, J.A.1    Vellon, L.2    Lupu, R.3
  • 71
    • 17444448391 scopus 로고    scopus 로고
    • The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis
    • Xing X., Wang S.C., Xia W., et al. The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis. Nat Med 2000, 6:189-195.
    • (2000) Nat Med , vol.6 , pp. 189-195
    • Xing, X.1    Wang, S.C.2    Xia, W.3
  • 72
    • 67650077386 scopus 로고    scopus 로고
    • P63 promotes cell survival through fatty acid synthase
    • Sabbisetti V., Di Napoli A., Seeley A., et al. p63 promotes cell survival through fatty acid synthase. PLoS ONE 2009, 4:e5877.
    • (2009) PLoS ONE , vol.4 , pp. e5877
    • Sabbisetti, V.1    Di Napoli, A.2    Seeley, A.3
  • 73
    • 67349136348 scopus 로고    scopus 로고
    • Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cells
    • Grunt T.W., Wagner R., Grusch M., et al. Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cells. Biochem Biophys Res Commun 2009, 385:454-459.
    • (2009) Biochem Biophys Res Commun , vol.385 , pp. 454-459
    • Grunt, T.W.1    Wagner, R.2    Grusch, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.