Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication

Toxicology and Applied Pharmacology

Volumn 281, Issue 2, 2014, Pages 185-194

  Vito, Stephen T ^a   Austin, Adam T ^b   Banks, Christopher N ^a   Inceoglu, Bora ^a   Bruun, Donald A ^a   Zolkowska, Dorota ^c   Tancredi, Daniel J ^b   Rogawski, Michael A ^c   Hammock, Bruce D ^a   Lein, Pamela J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Benzodiazepine; Diazepam; Neuroinflammation; Seizure; Soluble epoxide hydrolase; Tetramethylenedisulfotetramine

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ANTICONVULSIVE AGENT; ANTIINFLAMMATORY AGENT; DIAZEPAM; EPOXIDE HYDROLASE; GLIAL FIBRILLARY ACIDIC PROTEIN; HYDROLASE INHIBITOR; POISON; TETRAMETHYLENEDISULFOTETRAMINE; UNCLASSIFIED DRUG; [1 (2 METHANESULFUNYL PIPERIDIN 4 YL) 3 (4 TRIFLUOROMETHOXY) PHENYL] UREA; 1-(1-METHANESULFONYLPIPERIDIN-4-YL)-3-(4-TRIFLUOROMETHOXYPHENYL)UREA; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; BRIDGED COMPOUND; CARBANILAMIDE DERIVATIVE; ENZYME INHIBITOR; EPHX2 PROTEIN, MOUSE; PIPERIDINE DERIVATIVE;

ADULT; ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICONVULSANT THERAPY; ARTICLE; ASTROCYTOSIS; BRAIN CORTEX; CELL ACTIVATION; CELL STRUCTURE; CLONIC SEIZURE; CONTROLLED STUDY; DRUG MEGADOSE; ENZYME INHIBITION; HIPPOCAMPUS; IMMUNOREACTIVITY; MALE; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; TONIC SEIZURE; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; CHEMICALLY INDUCED; DISEASE MODEL; DRUG ADMINISTRATION; DRUG COMBINATION; DRUG EFFECTS; ELECTROENCEPHALOGRAM; ELECTROENCEPHALOGRAPHY; ENCEPHALITIS; ENZYMOLOGY; METABOLISM; PATHOPHYSIOLOGY; SEIZURES; TIME;

MURINAE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTICONVULSANTS; BRAIN; BRAIN WAVES; BRIDGED COMPOUNDS; DIAZEPAM; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; ELECTROENCEPHALOGRAPHY; ENCEPHALITIS; ENZYME INHIBITORS; EPOXIDE HYDROLASES; GABA MODULATORS; MALE; MICE; PHENYLUREA COMPOUNDS; PIPERIDINES; SEIZURES; TIME FACTORS;

EID: 84912107543     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.10.001     Document Type: Article

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