Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Inceoglu, Bora ^a   Zolkowska, Dorota ^b   Yoo, Hyun Ju ^c   Wagner, Karen M ^a   Yang, Jun ^a   Hackett, Edward ^a   Hwang, Sung Hee ^a   Lee, Kin Sing Stephen ^a   Rogawski, Michael A ^b   Morisseau, Christophe ^a   Hammock, Bruce D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Asan Institute for Life Sciences   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

(1 TRIFLUOROMETHOXYPHENYL 3 (1 PROPIONYLPIPERIDIN 4 YL) UREA); 1 (1 METHYLSULFONYLPIPERIDIN 4 YL) 3 (4 TRIFLUOROMETHOXY PHENYL) UREA; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; ANTICONVULSIVE AGENT; DIAZEPAM; EPOXIDE HYDROLASE; EPOXY FATTY ACID; EPOXYICOSATRIENOIC ACID; FATTY ACID; FINASTERIDE; LEUKOTRIENE; MACROGOL 400; PROSTAGLANDIN D2; PROSTAGLANDIN E2; PROSTANOID; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM FUNCTION; CONTROLLED STUDY; CONVULSION; DRUG MEGADOSE; DRUG POTENCY; DRUG SYNTHESIS; ELECTRIC SHOCK; ENZYME INHIBITION; ENZYME METABOLISM; GABAERGIC TRANSMISSION; GENE DELETION; MALE; MOUSE; NERVE EXCITABILITY; NEUROTRANSMISSION; NONHUMAN; PROTEIN FUNCTION; SEIZURE; SIGNAL TRANSDUCTION; TONIC SEIZURE;

ANIMALS; EICOSANOIDS; EPOXIDE HYDROLASES; GAMMA-AMINOBUTYRIC ACID; MALE; MICE; SEIZURES; SYNAPTIC TRANSMISSION;

EID: 84892561214     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0080922     Document Type: Article

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