Inhibition of soluble epoxide hydrolase after cardiac arrest/ cardiopulmonary resuscitation induces a neuroprotective phenotype in activated microglia and improves neuronal survival

Journal of Cerebral Blood Flow and Metabolism

Volumn 33, Issue 10, 2013, Pages 1574-1581

  Wang, Jianming ^a   Fujiyoshi, Tetsuhiro ^a   Kosaka, Yasuharu ^a   Raybuck, Jonathan D ^a   Lattal, K Matthew ^a   Ikeda, Mizuko ^a   Herson, Paco S ^a   Koerner, Ines P ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

brain injury; global ischemia; microglia; neuroinflammation

Indexed keywords

4 PHENYLCHALCONE OXIDE; CHALCONE DERIVATIVE; EPOXIDE HYDROLASE; HYDROLASE INHIBITOR; INTERLEUKIN 10; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CELL ACTIVATION; CELL DEATH; CELL SELECTION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME INHIBITION; HEART ARREST; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MEMORY; MICROGLIA; MOUSE; NERVE CELL; NEUROPROTECTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RESUSCITATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CARDIOPULMONARY RESUSCITATION; CELL DEATH; CELL SURVIVAL; CHALCONES; EPOXIDE HYDROLASES; HEART ARREST; INTERLEUKIN-10; INTERLEUKIN-1BETA; MALE; MEMORY; MICE; MICE, INBRED C57BL; MICROGLIA; NEURONS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84885021977     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2013.111     Document Type: Article

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