The effect of processing on the surface physical stability of amorphous solid dispersions

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 88, Issue 3, 2014, Pages 897-908

  Yang, Ziyi ^a,d   Nollenberger, Kathrin ^b   Albers, Jessica ^b   Moffat, Jonathan ^c   Craig, Duncan ^d   Qi, Sheng ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b EVONIK INDUSTRIES AG   (Germany)

^c OXFORD INSTRUMENTS PLASMA TECHNOLOGY   (United Kingdom)

^d UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Amorphous molecular dispersions; Hot melt extrusion; Physical stability; Spin coating; Surface crystallization; Surface drug enrichment

Indexed keywords

EUDRAGIT; FELODIPINE; POLYMER; EUDRAGIT E PO; POLYMETHACRYLIC ACID DERIVATIVE;

ARTICLE; ATOMIC FORCE MICROSCOPY; CONTROLLED STUDY; CRYSTALLIZATION; DISPERSION; DRUG SOLUBILITY; DRUG STABILITY; EVAPORATION; INFRARED SPECTROSCOPY; MELTING POINT; PROCESSING; ROOM TEMPERATURE; SCANNING ELECTRON MICROSCOPY; X RAY DIFFRACTION; CHEMISTRY; MEDICINAL CHEMISTRY; METABOLISM; PHYSICAL CHEMISTRY; PROCEDURES; SOLUBILITY; SURFACE PROPERTY;

CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DRUG STABILITY; FELODIPINE; PHYSICOCHEMICAL PROCESSES; POLYMETHACRYLIC ACIDS; SOLUBILITY; SURFACE PROPERTIES; X-RAY DIFFRACTION;

EID: 84912082465     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2014.07.013     Document Type: Article

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