Depletion of protease-activated receptor 2 but not protease-activated receptor 1 may confer protection against osteoarthritis in mice through extracartilaginous mechanisms

Arthritis and Rheumatology

Volumn 66, Issue 12, 2014, Pages 3337-3348

  Jackson, Miriam T ^a   Moradi, Babak ^a,b   Zaki, Sanaa ^a   Smith, Margaret M ^a   McCracken, Sharon ^a   Smith, Susan M ^a   Jackson, Christopher J ^a   Little, Christopher B ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 1ALPHA; METALLOPROTEINASE; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; ADAM PROTEIN; AGGRECAN; MESSENGER RNA; PROTEOGLYCAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE EROSION; CARTILAGE CELL; CARTILAGE DEGENERATION; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; FEMUR HEAD; FLOW CYTOMETRY; GENE EXPRESSION; GENOTYPE; HISTOLOGY; INFLAMMATORY CELL; KNEE MENISCUS; MACROPHAGE; MALE; MOUSE; NONHUMAN; OSTEOARTHRITIS; OSTEOLYSIS; OSTEOPHYTE; OSTEOSCLEROSIS; POLYMERASE CHAIN REACTION; SHAM PROCEDURE; SYNOVITIS; ANIMAL; ARTICULAR CARTILAGE; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; PROTECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURGERY;

ADAM PROTEINS; AGGRECANS; ANIMALS; CARTILAGE, ARTICULAR; CHONDROCYTES; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; MENISCI, TIBIAL; METALLOPROTEASES; MICE; MICE, KNOCKOUT; OSTEOARTHRITIS; PROTECTIVE FACTORS; PROTEOGLYCANS; RECEPTOR, PAR-1; RECEPTOR, PAR-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84912023310     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.38876     Document Type: Article

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