Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: A basic science study

Arthritis Research and Therapy

Volumn 9, Issue 6, 2007, Pages

  Boileau, Christelle ^a   Amiable, Nathalie ^a   Martel Pelletier, Johanne ^a   Fahmi, Hassan ^a   Duval, Nicolas ^b   Pelletier, Jean Pierre ^a  

^a NOTRE DAME HOSPITAL   (Canada)

^b Pavillon des Charmilles ^*  (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; COLLAGENASE 3; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 2 ACTIVATING PEPTIDE; SERYLLEUCYLISOLEUCYLGLYCYLLYSYLVALYLAMIDE; SN 50; STRESS ACTIVATED PROTEIN KINASE; SYNTHETIC PEPTIDE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AUTACOID; MESSENGER RNA; PRIMER DNA;

AGED; ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CATABOLISM; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; EXPLANT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; OSTEOARTHRITIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ADULT; ARTICULAR CARTILAGE; CASE CONTROL STUDY; GENETICS; METABOLISM; MIDDLE AGED; NUCLEOTIDE SEQUENCE; PATHOLOGY; TISSUE CULTURE TECHNIQUE;

ADULT; AGED; AGED, 80 AND OVER; BASE SEQUENCE; CARTILAGE, ARTICULAR; CASE-CONTROL STUDIES; CHONDROCYTES; DNA PRIMERS; HUMANS; INFLAMMATION MEDIATORS; MIDDLE AGED; OSTEOARTHRITIS; RECEPTOR, PAR-2; RNA, MESSENGER; SIGNAL TRANSDUCTION; TISSUE CULTURE TECHNIQUES; UP-REGULATION;

EID: 37249060017     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2329     Document Type: Article

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