Proinflammatory cytokines induce bronchial hyperplasia and squamous metaplasia in smokers implications for chronic obstructive pulmonary disease therapy

American Journal of Respiratory Cell and Molecular Biology

Volumn 47, Issue 1, 2012, Pages 67-79

  Herfs, Michael ^a   Hubert, Pascale ^a   Poirrier, Anne Lise ^b   Vandevenne, Patricia ^a   Renoux, Virginie ^a   Habraken, Yvette ^a   Cataldo, Didier ^a,b   Boniver, Jacques ^a   Delvenne, Philippe ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Cigarette smoke; Hyperplasia; Proinflammatory cytokine antagonists; Proinflammatory cytokines; Squamous metaplasia

Indexed keywords

CIGARETTE SMOKE; CYTOKERATIN 14; CYTOKERATIN 5; ETANERCEPT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; KI 67 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P63; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; STRESS ACTIVATED PROTEIN KINASE; TOCILIZUMAB; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS DISEASE; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; CILIATED EPITHELIUM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG POTENTIATION; EOSINOPHIL; EPITHELIUM CELL; EPITHELIUM HYPERPLASIA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOLOGY; INFLAMMATORY INFILTRATE; LUNG LAVAGE; LYMPHOCYTE; MACROPHAGE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PNEUMONIA; RESPIRATORY SYSTEM; SIGNAL TRANSDUCTION; SQUAMOUS CELL METAPLASIA; UPREGULATION;

ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; BRONCHI; CELLS, CULTURED; CYTOKINES; HUMANS; HYPERPLASIA; IMMUNOGLOBULIN G; INFLAMMATION; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; MAP KINASE SIGNALING SYSTEM; METAPLASIA; MICE; MICE, INBRED C57BL; NEUTROPHILS; NF-KAPPA B; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTORS, INTERLEUKIN-6; RECEPTORS, TUMOR NECROSIS FACTOR; SMOKE; SMOKING; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 84863798101     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2011-0353OC     Document Type: Article

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