A long non-coding RNA, GAS5, plays a critical role in the regulation of miR-21 during osteoarthritis

Journal of Orthopaedic Research

Volumn 32, Issue 12, 2014, Pages 1628-1635

  Song, Jinsoo ^a   Ahn, Chihyun ^a   Chun, Churl Hong ^b   Jin, Eun Jung ^a,c  

^a Department of Biological Sciences   (South Korea)

^b Wonkwang University School of Medicine   (South Korea)

^c Wonkwang University   (South Korea)

Author keywords

Apoptosis; Autophagy; GAS5; MiR 21; Osteoarthritis

Indexed keywords

AGGRECANASE 1; COLLAGENASE 3; GELATINASE A; GELATINASE B; GROWTH ARREST SPECIFIC 5; LC 3B PROTEIN; LONG UNTRANSLATED RNA; MICRORNA 21; PROTEIN; STROMELYSIN; UNCLASSIFIED DRUG; GAS5 LONG NON-CODING RNA, HUMAN; MICRORNA; MIRN21 MICRORNA, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; CARTILAGE BIOPSY; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL ADHESION; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; GROWTH PLATE; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OSTEOARTHRITIS; PATHOGENESIS; PROTEIN EXPRESSION; RNA ANALYSIS; TOTAL KNEE REPLACEMENT; UPREGULATION; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; PHYSIOLOGY;

ANIMALS; APOPTOSIS; AUTOPHAGY; GENE EXPRESSION REGULATION; HUMANS; MALE; MICE; MICRORNAS; OSTEOARTHRITIS; RNA, LONG NONCODING;

EID: 84911805269     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22718     Document Type: Article

References (48)

1. Duncan R, Peat G, Thomas E, et al. 2007. Symptoms and radiographic osteoarthritis: not as discordant as they are made out to be? Ann Rheum Dis 66:86-91.
2. Findlay DM, Atkins GJ. 2014. Osteoblast-chondrocyte interactions in osteoarthritis. Curr Osteoporos Rep 12:127-134.
3. Scanzello CR, Umoh E, Pessler F, et al. 2009. Local cytokine profiles in knee osteoarthritis: elevated synovial fluid inter-leukin-15 differentiates early from end-stage disease. Osteo-arthritis Cartilage 17:1040-1048.
4. Brooks P. 2003. Inflammation as an important feature of osteoarthritis. Bull World Health Organ 81:689-690.
5. Blanco FJ, Guitian R, Vázquez-Martul E, et al. 1998. Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology. Arthritis Rheum 41:284-289.
6. Hashimoto S, Ochs RL, Komiya S, et al. 1998. Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis. Arthritis Rheum 41:1632-1638.
7. Sharif M, Whitehouse A, Sharman P, et al. 2004. Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase-3. Arthritis Rheum 50:507-515.
8. Thomas CM, Fuller CJ, Whittles CE, et al. 2011. Chondro-cyte death by apoptosis is associated with the initiation and severity of articular cartilage degradation. Int J Rheum Dis 14:191-198.
9. Eken SM, Jin H, Chernogubova E, et al. 2013. Making sense in antisense: therapeutic potential of noncoding RNAs in diabetes-induced vascular dysfunction. J Diabetes Res 2013:834727.
10. Enfield KS, Pikor LA, Martinez VD, et al. 2012. Mechanistic Roles of Noncoding RNAs in Lung Cancer Biology and Their Clinical Implications. Genet Res Int 2012:737416.
11. Hwang HW, Mendell JT. 2006. MicroRNAs in cell proliferation, cell death, and tumorigenesis. Br J Cancer 94:776-780.
12. Song J, Lee M, Kim D, et al. 2013. MicroRNA-181b regulates articular chondrocytes differentiation and cartilage integrity. Biochem Biophys Res Commun 431:210-214.
13. Miyaki S, Asahara H. 2012. Macro view of microRNA function in osteoarthritis. Nat Rev Rheumatol 8:543-552.
14. Chow J, Heard E. 2009. X inactivation and the complexities of silencing a sex chromosome. Curr Opin Cell Biol 21:359-366.
15. Agrelo R, Wutz A. 2010. X inactivation and disease. Semin Cell Dev Biol 21:194-200.
16. Rinn JL, Kertesz M, Wang JK, et al. 2007. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 129:1311-1323.
17. Kino T, Hurt DE, Ichijo T, et al. 2010. Noncoding RNA gas5 is a growth arrest-and starvation-associated repressor of the glucocorticoid receptor. Sci Signal 3:ra8.
18. Mourtada-Maarabouni M, Hasan AM, Farzaneh F, et al. 2010. Inhibition of human T-cell proliferation by mammalian target of rapamycin (mTOR) antagonists requires noncoding RNA growth-arrest-specific transcript 5 (GAS5). Mol Pharmacol 78:19-28.
19. Mourtada-Maarabouni M, Pickard MR, Hedge VL, et al. 2009. GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer. Oncogene 28:195-208.
20. Meredith JE Jr, Fazeli B, Schwartz MA. 1993. The extracellular matrix as a cell survival factor. Mol Biol Cell 4:953-961.
21. Manabe S, Gu Z, Lipton SA. 2005. Activation of matrix metalloproteinase-9 via neuronal nitric oxide synthase contributes to NMDA-induced retinal ganglion cell death. Invest Ophthalmol Vis Sci 46:4747-4753.
22. Guo L, Mos SE, Alexander RA, et al. 2005. Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix. Invest Ophthalmol Vis Sci 46:175-182.
23. Granata F, Petraroli A, Boilard E, et al. 2005. Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor. J Immunol 174:464-474.
24. Lakhani SA, Masud A, Kuida K, et al. 2006. Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science 311:847-851.
25. Chin YE, Kitagawa M, Kuida K, et al. 1997. Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis. Mol Cell Biol 17:5328-5337.
26. Guicciardi ME, Leist M, Gores GJ. 2004. Lysosomes in cell death. Oncogene 23:2881-2890.
27. Lum JJ, Bauer DE, Kong M, et al. 2005. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120:237-248.
28. Williams GT, Mourtada-Maarabouni M, Farzaneh F. 2011. A critical role for non-coding RNA GAS5 in growth arrest and rapamycin inhibition in human T-lymphocytes. Biochem Soc Trans 39:482-486.
29. Ozgür E1, Mert U, Isin M, et al. 2013. Differential expression of long non-coding RNAs during genotoxic stress-induced apoptosis in HeLa and MCF-7 cells. Clin Exp Med 13:119-126.
30. Lee J, Kotliarova S, Kotliarov Y, et al. 2006. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 9:391-403.
31. Mourtada-Maarabouni M, Pickard MR, Hedge VL, et al. 2006. GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer. Oncogene 28:195-208.
32. Zhang Z, Zhu Z, Watabe K, et al. 2013. Negative regulation of lncRNA GAS5 by miR-21. Cell Death Differ 20:1558-1568.
33. Raho G, Barone V, Rossi D, et al. 2000. The gas 5 gene shows four alternative splicing patterns without coding for a protein. Gene 256:13-17.
34. Shi X, Sun M, Liu H, et al. 2013. Long non-coding RNAs: a new frontier in the study of human diseases. Cancer Lett 339:159-166.
35. Gee HE, Buffa FM, Camps C, et al. 2011. The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis. Br J Cancer 104:1168-1177.
36. Pickard MR, Mourtada-Maarabouni M, Williams GT. 2013. Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines. Biochim Biophys Acta 1832:1613-1623.
37. Lu X, Fang Y, Wang Z, et al. 2013. Downregulation of gas5 increases pancreatic cancer cell proliferation by regulating CDK6. Cell Tissue Res 354:891-896.
38. Wang J, Liu X, Wu H, et al. 2010. CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer. Nucleic Acids Res 38:5366-5383.
39. Li L, Zhou L, Li Y, et al. 2014. MicroRNA-21 stimulates gastric cancer growth and invasion by inhibiting the tumor suppressor effects of programmed cell death protein 4 and phosphatase and tensin homolog. J BUON 19:228-236.
40. Ruan Q, Wang P, Wang T, et al. 2014. MicroRNA-21 regulates T-cell apoptosis by directly targeting the tumor suppressor gene Tipe2. Cell Death Dis 5:e1095.
41. Lo TF, Tsai WC, Chen ST. 2013. MicroRNA-21-3p, a berberine-induced miRNA, directly down-regulates human methionine adenosyltransferases 2A and 2B and inhibits hepatoma cell growth. PLoS One 8:e75628.
42. Meng F, Henson R, Wehbe-Janek H, et al. 2007. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133:647-658.
43. Medina PP, Nolde M, Slack FJ. 2010. OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lympho-ma. Nature 467:86-90.
44. Ren J, Sun Y, Zhao X, et al. 2012. Downregulation of miR-21 regulates MMP-2 expression and suppress migration of Laryngeal squamous cell carcinoma. Head Neck Oncol 4:65.
45. Deng X, Zhong Y, Gu L, et al. 2013. MiR-21 involve in ERK-mediated upregulation of MMP9 in the rat hippocampus following cerebral ischemia. Brain Res Bull 94:56-62.
46. Wang J, Gao Y, Ma M, et al. 2013. Effect of miR-21 on renal fibrosis by regulating MMP-9 and TIMP1 in kk-ay diabetic nephropathy mice. Cell Biochem Biophys 67:537-546.
47. Gabriely G, Wurdinger T, Kesari S, et al. 2008. MicroRNA 21 promotes glioma invasion by targeting matrix metal-loproteinase regulators. Mol Cell Biol 28:5369-5380.
48. Niu J, Shi Y, Tan G, et al. 2012. DNA damage induces NF-kB-dependent microRNA-21 up-regulation and promotes breast cancer cell invasion. J Biol Chem 287:21783-21795.