Inhibition of human T-cell proliferation by mammalian target of rapamycin (mTOR) antagonists requires noncoding RNA growth-arrest-specific transcript 5 (GAS5)

Molecular Pharmacology

Volumn 78, Issue 1, 2010, Pages 19-28

  Mourtada Maarabouni, Mirna ^a   Hasan, Anwar M ^a   Farzaneh, Farzin ^b   Williams, Gwyn T ^a  

^a KEELE UNIVERSITY   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PROTEIN GAS 5; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; LEUKEMIA; PRIORITY JOURNAL; RNA INTERFERENCE; RNA TRANSLATION; T LYMPHOCYTE; UPREGULATION;

CELL LINE; DOWN-REGULATION; FLOW CYTOMETRY; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKEMIA; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL NUCLEOLAR; RNA, UNTRANSLATED; T-LYMPHOCYTES;

EID: 77953792493     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.110.064055     Document Type: Article

References (47)

1. Abraham RT and Wiederrecht GJ (1996) Immunopharmacology of rapamycin. Annu Rev Immunol 14:483-510.
2. Ashwell JD, Lu FW, and Vacchio MS (2000) Glucocorticoids in T cell development and function. Annu Rev Immunol 18:309-345.
3. Bai X, Ma D, Liu A, Shen X, Wang QJ, Liu Y, and Jiang Y (2007) Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. Science 318:977-980.
4. Abdel-Karim IA and Giles FJ (2008) Mammalian target of rapamycin as a target in hematological malignancies. Curr Probl Cancer 32:161-177.
5. Brunn GJ, Hudson CC, Sekulić A, Williams JM, Hosoi H, Houghton PJ, Lawrence JC Jr, and Abraham RT (1997) Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science 277:99-101.
6. Chiang GG and Abraham RT (2007) Targeting the mTOR signaling network in cancer. Trends Mol Med 13:433-442.
7. Coccia EM, Cicala C, Charlesworth A, Ciccarelli C, Rossi GB, Philipson L, and Sorrentino V (1992) Regulation and expression of a growth arrest-specific gene (gas5) during growth, differentiation, and development. Mol Cell Biol 12:3514-3521.
8. 1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin. Blood 101:278-285.
9. Dumont FJ, Melino MR, Staruch MJ, Koprak SL, Fischer PA, and Sigal NH (1990) The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells. J Immunol 144:1418-1424.
10. Feng Z, Zhang H, Levine AJ, and Jin S (2005) The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci USA 102:8204-8209.
11. Fingar DC, Richardson CJ, Tee AR, Cheatham L, Tsou C, and Blenis J (2004) mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol 24:200-216.
12. Fleming JV, Hay SM, Harries DN, and Rees WD (1998) Effects of nutrient deprivation and differentiation on the expression of growth-arrest genes (gas and gadd) in F9 embryonal carcinoma cells. Biochem J 330:573-579.
13. Gharagozloo M and Amirghofran Z (2007) Effects of silymarin on the spontaneous proliferation and cell cycle of human peripheral blood leukemia T cells. J Cancer Res Clin Oncol 133:525-532.
14. Greaves MF and Bauminger S (1972) Activation of T and B lymphocytes by insoluble phytomitogens. Nature New Biol, 235:57-69.
15. Hay N and Sonenberg N (2004) Upstream and downstream of mTOR. Genes Dev 18:1926-1945.
16. Hong F, Larrea MD, Doughty C, Kwiatkowski DJ, Squillace R, and Slingerland JM (2008) mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation. Mol Cell 30:701-711.
17. Isken O and Maquat LE (2007) Quality control of eukaryotic mRNA, safeguarding cells from abnormal mRNA function. Genes Dev 21:1833-1856.
18. Jiang BH and Liu LZ (2008) Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment. Drug Resist Updat 11:63-76.
19. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, and Craig RW (1991) Participation of P53 protein in the cellular-response to DNA damage. Cancer Re 51: 6304-6311.
20. Kino T, Hurt DE, Ichijo T, Nader N, and Chrousos GP (2010) Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor. Sci Signal 3:ra8.
21. Ma WW and Jimeno A (2007) Temsirolimus. Drugs Today (Barc) 43:659-669.
22. Majewski M, Korecka M, Joergensen J, Fields L, Kossev P, Schuler W, Shaw L, and Wasik MA (2003) Immunosuppressive TOR kinase inhibitor everolimus (RAD) suppresses growth of cells derived from posttransplant lymphoproliferative disorder at allograft-protecting doses. Transplantation 75:1710-1717.
23. Meyuhas O (2000) Synthesis of the translational apparatus is regulated at the translational level. Eur J Biochem 267:6321-6330.
24. Minowada J, Onuma T, and Moore GE (1972) Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes. J Natl Cancer Inst 49:891-895.
25. Mourtada-Maarabouni M, Hedge VL, Kirkham L, Farzaneh F, and Williams GT (2008) Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5). J Cell Sci 121:939-946.
26. Muller AJ, Chatterjee S, Teresky A, and Levine AJ (1998) The gas5 gene is disrupted by a frameshift mutation within its longest open reading frame in several inbred mouse strains and maps to murine chromosome 1. Mamm Genome 9:773-774.
27. Norman MR and Thompson EB (1977) Characterization of a glucocorticoid-sensitive human lymphoid-cell line. Cancer Res 37:3785-3791. (Pubitemid 8197911)
28. Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372:570-573.
29. Pelczar P and Filipowicz W (1998) The host gene for intronic U17 small nucleolar RNAs in mammals has no protein-coding potential and is a member of the 5′-terminal oligopyrimidine gene family. Mol Cell Biol 18:4509-4518. (Pubitemid 28343035)
30. Powell JD, Lerner CG, and Schwartz RH (1999) Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation. J Immunol 162:2775-2784.
31. Raho G, Barone V, Rossi D, Philipson L, and Sorrentino V (2000) The gas 5 gene shows four alternative splicing patterns without coding for a protein. Gene 256: 13-17.
32. Rosenwald IB, Lazaris-Karatzas A, Sonenberg N, and Schmidt EV (1993) Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E. Mol Cell Biol 13:7358-7363. (Pubitemid 23354259)
33. Schneider C, King RM, and Philipson L (1988) Genes specifically expressed at growth arrest of mammalian cells. Cell 54:787-793.
34. Scholzen T and Gerdes J (2000) The Ki-67 protein: from the known and the unknown. J Cell Physiol 182:311-322.
35. Sehgal SN, Baker H, and Vézina C (1975) Rapamycin (Ay-22,989), A new antifungal antibiotic. II. Fermentation, isolation and characterization. J Antibiot 28:727-732.
36. Smith CM and Steitz JA (1998) Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5′-terminal oligopyrimidine gene family reveals common features of snoRNA host genes. Mol Cell Biol 18:6897-6909.
37. Soulard A and Hall MN (2007) SnapShot: mTOR signaling. Cell 129:434-U14.
38. Stark GR and Gudkov AV (1999) Forward genetics in mammalian cells: functional approaches to gene discovery. Hum Mol Genet 8:1925-1938.
39. Tee AR and Blenis J (2005) mTOR, translational control and human disease. Sem Cell Dev Biol 16:29-37.
40. Tycowski KT, Shu MD, and Steitz JA (1996) A mammalian gene with introns instead of exons generating stable RNA products. Nature 379:464-466.
41. White RA, Terry NH, Meistrich ML, and Calkins DP (1990) Improved Method for Computing Potential Doubling Time from Flow Cytometric Data. Cytometry 11: 314-317.
42. Williams GT, Critchlow MR, Hedge VL, and O'Hare KB (1998) Molecular failure of apoptosis: inappropriate cell survival and mutagenesis? Toxicol Lett 102-103:485-489.
43. Williams GT and Farzaneh F (2004) The use of gene function to identify the ratelimiting steps controlling cell fate. Cancer Immunol Immunother 53:160-165.
44. Williams GT, Hughes JP, Stoneman V, Anderson CL, McCarthy NJ, Mourtada-Maarabouni M, Pickard M, Hedge VL, Trayner I, and Farzaneh F (2006) Isolation of genes controlling apoptosis through their effects on cell survival. Gene Ther Mol Biol 10:255-262.
45. Wullschleger S, Loewith R, and Hall MN (2006) TOR signaling in growth and metabolism. Cell 124:471-484.
46. Zimmer SG, DeBenedetti A, and Graff JR (2000) Translational control of malignancy: the mRNA cap-binding protein, eIF-4E, as a central regulator of tumor formation, growth, invasion and metastasis. Anticancer Res 20:1343-1351.
47. Zhang X, Bommareddy A, Chen W, Khalifa S, Kaushik RS, Fahmy H, and Dwivedi C. (2009) Sarcophine-diol, a chemopreventive agent of skin cancer, inhibits cell growth and induces apoptosis through extrinsic pathway in human epidermoid carcinoma A431 cells. Transl Oncol 2:21-30.