-
4
-
-
41149161849
-
Molecular genetics of pancreatic ductal adenocarcinomas and recent implications for translational efforts
-
Feldmann G, Maitra A. Molecular genetics of pancreatic ductal adenocarcinomas and recent implications for translational efforts. J Mol Diagn 2008;10:111-22
-
(2008)
J Mol Diagn
, vol.10
, pp. 111-122
-
-
Feldmann, G.1
Maitra, A.2
-
5
-
-
84869091997
-
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
-
Biankin AV, Waddell N, Kassahn KS, et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 2012;494:399-405
-
(2012)
Nature
, vol.494
, pp. 399-405
-
-
Biankin, A.V.1
Waddell, N.2
Kassahn, K.S.3
-
6
-
-
84861990162
-
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma
-
Pérez-Mancera PA, Rust AG, van der Weyden L, et al. The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature 2012;486:266-70
-
(2012)
Nature
, vol.486
, pp. 266-270
-
-
Pérez-Mancera, P.A.1
Rust, A.G.2
Van Der Weyden, L.3
-
7
-
-
84864285223
-
RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis
-
Yu M, Ting DT, Stott SL, et al. RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis. Nature 2012;487:510-13
-
(2012)
Nature
, vol.487
, pp. 510-513
-
-
Yu, M.1
Ting, D.T.2
Stott, S.L.3
-
8
-
-
64849092309
-
Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene
-
Jones S, Hruban RH, Kamiyama M, et al. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science 2009;324:217
-
(2009)
Science
, vol.324
, pp. 217
-
-
Jones, S.1
Hruban, R.H.2
Kamiyama, M.3
-
9
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
Jones S, Zhang X, Parsons DW, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008;321:1801-6
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
Zhang, X.2
Parsons, D.W.3
-
10
-
-
78049398107
-
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
-
Yachida S, Jones S, Bozic I, et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 2010;467:1114-17
-
(2010)
Nature
, vol.467
, pp. 1114-1117
-
-
Yachida, S.1
Jones, S.2
Bozic, I.3
-
11
-
-
9144266295
-
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
-
Hingorani SR, Petricoin EF, Maitra A, et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 2003;4:437-50
-
(2003)
Cancer Cell
, vol.4
, pp. 437-450
-
-
Hingorani, S.R.1
Petricoin, E.F.2
Maitra, A.3
-
12
-
-
19344362405
-
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
-
Hingorani SR, Wang L, Multani AS, et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 2005;7:469-83
-
(2005)
Cancer Cell
, vol.7
, pp. 469-483
-
-
Hingorani, S.R.1
Wang, L.2
Multani, A.S.3
-
13
-
-
33646577163
-
Genetics and biology of pancreatic ductal adenocarcinoma
-
Hezel AF, Kimmelman AC, Stanger BZ, et al. Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev 2006;20:1218-49
-
(2006)
Genes Dev
, vol.20
, pp. 1218-1249
-
-
Hezel, A.F.1
Kimmelman, A.C.2
Stanger, B.Z.3
-
14
-
-
79958710624
-
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence
-
Guerra C, Collado M, Navas C, et al. Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence. Cancer Cell 2011;19:728-39
-
(2011)
Cancer Cell
, vol.19
, pp. 728-739
-
-
Guerra, C.1
Collado, M.2
Navas, C.3
-
15
-
-
77951744260
-
The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer
-
Fendrich V, Chen NM, Neef M, et al. The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer. Gut 2010;59:630-7
-
(2010)
Gut
, vol.59
, pp. 630-637
-
-
Fendrich, V.1
Chen, N.M.2
Neef, M.3
-
16
-
-
84863980687
-
Chemoprevention of pancreatic cancer - One step closer
-
Fendrich V. Chemoprevention of pancreatic cancer - one step closer. Langenbecks Arch Surg 2012;397:495-505
-
(2012)
Langenbecks Arch Surg
, vol.397
, pp. 495-505
-
-
Fendrich, V.1
-
17
-
-
84856088337
-
EMT and dissemination precede pancreatic tumor formation
-
Rhim AD, Mirek ET, Aiello NM, et al. EMT and dissemination precede pancreatic tumor formation. Cell 2012;148:349-61
-
(2012)
Cell
, vol.148
, pp. 349-361
-
-
Rhim, A.D.1
Mirek, E.T.2
Aiello, N.M.3
-
18
-
-
8244254377
-
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
-
Burris HA III, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997;15:2403-13
-
(1997)
J Clin Oncol
, vol.15
, pp. 2403-2413
-
-
Burris, H.A.1
Moore, M.J.2
Andersen, J.3
-
19
-
-
34249933404
-
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
-
Moore MJ, Goldstein D, Hamm J, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2007;25:1960-6
-
(2007)
J Clin Oncol
, vol.25
, pp. 1960-1966
-
-
Moore, M.J.1
Goldstein, D.2
Hamm, J.3
-
20
-
-
79955921754
-
FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
-
Conroy T, Desseigne F, Ychou M, et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med 2011;364:1817-25
-
(2011)
N Engl J Med
, vol.364
, pp. 1817-1825
-
-
Conroy, T.1
Desseigne, F.2
Ychou, M.3
-
21
-
-
80052886108
-
Emerging pathways and future targets for the molecular therapy of pancreatic cancer
-
Vaccaro V, Melisi D, Bria E, et al. Emerging pathways and future targets for the molecular therapy of pancreatic cancer. Expert Opin Ther Targets 2011;15:1183-96
-
(2011)
Expert Opin Ther Targets
, vol.15
, pp. 1183-1196
-
-
Vaccaro, V.1
Melisi, D.2
Bria, E.3
-
22
-
-
84885792555
-
Pancreas organogenesis: From lineage determination to morphogenesis
-
Shih HP, Wang A, Sander M. Pancreas organogenesis: from lineage determination to morphogenesis. Annu Rev Cell Dev Biol 2013;29:81-105
-
(2013)
Annu Rev Cell Dev Biol
, vol.29
, pp. 81-105
-
-
Shih, H.P.1
Wang, A.2
Sander, M.3
-
23
-
-
0028314969
-
IDX-1: A new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene
-
Miller CP, McGhee RE, Habener JF. IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J 1994;13:1145-56
-
(1994)
EMBO J
, vol.13
, pp. 1145-1156
-
-
Miller, C.P.1
McGhee, R.E.2
Habener, J.F.3
-
24
-
-
0028206319
-
XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor
-
Peshavaria M, Gamer L, Henderson E, et al. XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor. Mol Endocrinol 1994;8:806-16
-
(1994)
Mol Endocrinol
, vol.8
, pp. 806-816
-
-
Peshavaria, M.1
Gamer, L.2
Henderson, E.3
-
25
-
-
0029868156
-
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
-
Offield MF, Jetton TL, Labosky PA, et al. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 1996;122:983-95
-
(1996)
Development
, vol.122
, pp. 983-995
-
-
Offield, M.F.1
Jetton, T.L.2
Labosky, P.A.3
-
26
-
-
0037125977
-
Experimental control of pancreatic development and maintenance
-
Holland AM, Hale MA, Kagami H, et al. Experimental control of pancreatic development and maintenance. Proc Natl Acad Sci USA 2002;99:12236-41
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12236-12241
-
-
Holland, A.M.1
Hale, M.A.2
Kagami, H.3
-
27
-
-
0028869514
-
Expression of murine STF-1, a putative insulin gene transcription factor, in b cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny
-
Guz Y, Montminy MR, Stein R, et al. Expression of murine STF-1, a putative insulin gene transcription factor, in b cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 1995;121:149-61
-
(1995)
Development
, vol.121
, pp. 149-161
-
-
Guz, Y.1
Montminy, M.R.2
Stein, R.3
-
28
-
-
0032525981
-
Beta-cell specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes
-
Ahlgren U, Jonsson J, Jonsson L, et al. Beta-cell specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev 1998;12:1763-8
-
(1998)
Genes Dev
, vol.12
, pp. 1763-1768
-
-
Ahlgren, U.1
Jonsson, J.2
Jonsson, L.3
-
31
-
-
0033009460
-
The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration
-
Sharma A, Zangen DH, Reitz P, et al. The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes 1999;48:507-13
-
(1999)
Diabetes
, vol.48
, pp. 507-513
-
-
Sharma, A.1
Zangen, D.H.2
Reitz, P.3
-
32
-
-
48549095907
-
Hedgehog signaling is required for effective regeneration of exocrine pancreas
-
Fendrich V, Esni F, Garay MV, et al. Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology 2008;135:621-31
-
(2008)
Gastroenterology
, vol.135
, pp. 621-631
-
-
Fendrich, V.1
Esni, F.2
Garay, M.V.3
-
33
-
-
57749113202
-
Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice
-
Habbe N, Shi G, Meguid RA, et al. Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci USA 2008;105:18913-18
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 18913-18918
-
-
Habbe, N.1
Shi, G.2
Meguid, R.A.3
-
34
-
-
0041827085
-
Increased PDX-1 expression is associated with outcome in patients with pancreatic cancer
-
Koizumi M, Doi R, Toyoda E, et al. Increased PDX-1 expression is associated with outcome in patients with pancreatic cancer. Surgery 2003;134:260-6
-
(2003)
Surgery
, vol.134
, pp. 260-266
-
-
Koizumi, M.1
Doi, R.2
Toyoda, E.3
-
35
-
-
20044388765
-
Tissue microarray analyses of pancreatic duodenal homeobox-1 in human cancers
-
Wang XP, Li ZJ, Magnusson J, et al. Tissue microarray analyses of pancreatic duodenal homeobox-1 in human cancers. World J Surg 2005;29:334-8
-
(2005)
World J Surg
, vol.29
, pp. 334-338
-
-
Wang, X.P.1
Li, Z.J.2
Magnusson, J.3
-
36
-
-
55949107920
-
PDX-1 acts as a potential molecular target for treatment of human pancreatic cancer
-
Liu S, Ballian N, Belaguli NS, et al. PDX-1 acts as a potential molecular target for treatment of human pancreatic cancer. Pancreas 2008;37:210-20
-
(2008)
Pancreas
, vol.37
, pp. 210-220
-
-
Liu, S.1
Ballian, N.2
Belaguli, N.S.3
-
37
-
-
79551691442
-
PDX-1: Demonstration of oncogenic properties in pancreatic cancer
-
Liu SH, Patel S, Gingras MC, et al. PDX-1: demonstration of oncogenic properties in pancreatic cancer. Cancer 2011;117:723-33
-
(2011)
Cancer
, vol.117
, pp. 723-733
-
-
Liu, S.H.1
Patel, S.2
Gingras, M.C.3
-
38
-
-
84864667426
-
PDX-1 is a therapeutic target for pancreatic cancer, insulinoma and islet neoplasia using a novel RNA interference platform
-
Liu SH, Rao DD, Nemunaitis J, et al. PDX-1 is a therapeutic target for pancreatic cancer, insulinoma and islet neoplasia using a novel RNA interference platform. PLoS One 2012;7:e40452
-
(2012)
PLoS One
, vol.7
, pp. e40452
-
-
Liu, S.H.1
Rao, D.D.2
Nemunaitis, J.3
|