DNA end recognition by the Mre11 nuclease dimer: Insights into resection and repair of damaged DNA

EMBO Journal

Volumn 33, Issue 20, 2014, Pages 2422-2435

  Sung, Sihyun ^a   Li, Fuyang ^b,c   Park, Young Bong ^a   Kim, Jin Seok ^a   Kim, Ae Kyoung ^d   Song, Ok Kyu ^d   Kim, Jiae ^a   Che, Jun ^b,c   Lee, Sang Eun ^b,c   Cho, Yunje ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b Mays Cancer Center at UT Health San Antonio   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d Panbionet Corporation   (South Korea)

Author keywords

conserved basic region; crystal structure; DNA end recognition; DSB repair; Mre11 DNA

Indexed keywords

DIMER; DNA; DNA B; DOUBLE STRANDED DNA; MONOMER; MRE11 PROTEIN; MUTANT PROTEIN; NUCLEASE; RAD50 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ARCHAEAL DNA; ARCHAEAL PROTEIN; DEOXYRIBONUCLEASE; EXODEOXYRIBONUCLEASE; MRE11 PROTEIN, ARCHAEAL; PROTEIN BINDING;

ARTICLE; CHROMOSOME BREAKAGE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA CROSS LINKING; DNA DAMAGE; DNA DENATURATION; DNA END JOINING REPAIR; ENZYME ACTIVE SITE; METHANOCALDOCOCCUS JANNASCHII; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN CROSS LINKING; PROTEIN DNA BINDING; PROTEIN QUATERNARY STRUCTURE; PROTEIN STRUCTURE; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; DNA MUTATIONAL ANALYSIS; DOUBLE STRANDED DNA BREAK; ENZYMOLOGY; GENETICS; METABOLISM; METHANOCALDOCOCCUS; MOLECULAR GENETICS; SEQUENCE ALIGNMENT; STRUCTURAL MODEL; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ARCHAEAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DNA BREAKS, DOUBLE-STRANDED; DNA END-JOINING REPAIR; DNA MUTATIONAL ANALYSIS; DNA, ARCHAEAL; ENDODEOXYRIBONUCLEASES; EXODEOXYRIBONUCLEASES; METHANOCALDOCOCCUS; MODELS, MOLECULAR; MODELS, STRUCTURAL; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; SEQUENCE ALIGNMENT;

EID: 84911480207     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201488299     Document Type: Article

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