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Volumn 19, Issue 11, 2011, Pages 1591-1602

Crystal structure of human Mre11: Understanding tumorigenic mutations

Author keywords

[No Author keywords available]

Indexed keywords

MRE11 PROTEIN; NIBRIN; NUCLEASE;

EID: 80855133532     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2011.09.010     Document Type: Article
Times cited : (74)

References (49)
  • 3
    • 0032721091 scopus 로고    scopus 로고
    • The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae
    • D.A. Bressan, B.K. Baxter, and J.H. Petrini The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae Mol. Cell. Biol. 19 1999 7681 7687 (Pubitemid 29493431)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.11 , pp. 7681-7687
    • Bressan, D.A.1    Baxter, B.K.2    Petrini, J.H.J.3
  • 6
    • 0032076248 scopus 로고    scopus 로고
    • The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
    • DOI 10.1016/S0092-8674(00)81175-7
    • J.P. Carney, R.S. Maser, H. Olivares, E.M. Davis, M. Le Beau, J.R. Yates 3rd, L. Hays, W.F. Morgan, and J.H. Petrini The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response Cell 93 1998 477 486 (Pubitemid 28232091)
    • (1998) Cell , vol.93 , Issue.3 , pp. 477-486
    • Carney, J.P.1    Maser, R.S.2    Olivares, H.3    Davis, E.M.4    Le Beau, M.5    Yates III, J.R.6    Hays, L.7    Morgan, W.F.8    Petrini, J.H.J.9
  • 8
    • 0032576565 scopus 로고    scopus 로고
    • Isolation of hMRE11B: Failure to complement yeast mre11 defects due to species-specific protein interactions
    • DOI 10.1016/S0378-1119(98)00530-7, PII S0378111998005307
    • M. Chamankhah, Y.F. Wei, and W. Xiao Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions Gene 225 1998 107 116 (Pubitemid 29030440)
    • (1998) Gene , vol.225 , Issue.1-2 , pp. 107-116
    • Chamankhah, M.1    Wei, Y.-F.2    Xiao, W.3
  • 9
    • 0036276388 scopus 로고    scopus 로고
    • The Mre11 complex: At the crossroads of DNA repair and checkpoint signalling
    • DOI 10.1038/nrm805
    • D. D'Amours, and S.P. Jackson The Mre11 complex: at the crossroads of dna repair and checkpoint signalling Nat. Rev. Mol. Cell Biol. 3 2002 317 327 (Pubitemid 34619266)
    • (2002) Nature Reviews Molecular Cell Biology , vol.3 , Issue.5 , pp. 317-327
    • D'Amours, D.1    Jackson, S.P.2
  • 11
    • 0034997651 scopus 로고    scopus 로고
    • Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization
    • DOI 10.1128/MCB.21.6.2184-2191.2001
    • A. Desai-Mehta, K.M. Cerosaletti, and P. Concannon Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization Mol. Cell. Biol. 21 2001 2184 2191 (Pubitemid 32479638)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.6 , pp. 2184-2191
    • Desai-Mehta, A.1    Cerosaletti, K.M.2    Concannon, P.3
  • 12
    • 0029742576 scopus 로고    scopus 로고
    • Human RAD50 is physically associated with human Mre11: Identification of a conserved multiprotein complex implicated in recombinational DNA repair
    • G.M. Dolganov, R.S. Maser, A. Novikov, L. Tosto, S. Chong, D.A. Bressan, and J.H. Petrini Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair Mol. Cell. Biol. 16 1996 4832 4841 (Pubitemid 26272138)
    • (1996) Molecular and Cellular Biology , vol.16 , Issue.9 , pp. 4832-4841
    • Dolganov, G.M.1    Maser, R.S.2    Novikov, A.3    Tosto, L.4    Chong, S.5    Bressan, D.A.6    Petrini, J.H.J.7
  • 13
    • 24044538903 scopus 로고    scopus 로고
    • IUPred: Web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content
    • DOI 10.1093/bioinformatics/bti541
    • Z. Dosztányi, V. Csizmok, P. Tompa, and I. Simon IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content Bioinformatics 21 2005 3433 3434 (Pubitemid 41222453)
    • (2005) Bioinformatics , vol.21 , Issue.16 , pp. 3433-3434
    • Dosztanyi, Z.1    Csizmok, V.2    Tompa, P.3    Simon, I.4
  • 15
    • 15844394846 scopus 로고    scopus 로고
    • Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
    • DOI 10.1038/nature03442
    • J. Falck, J. Coates, and S.P. Jackson Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage Nature 434 2005 605 611 (Pubitemid 40488547)
    • (2005) Nature , vol.434 , Issue.7033 , pp. 605-611
    • Falck, J.1    Coates, J.2    Jackson, S.P.3
  • 16
    • 12744273401 scopus 로고    scopus 로고
    • Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder
    • M. Fernet, M. Gribaa, M.A. Salih, M.Z. Seidahmed, J. Hall, and M. Koenig Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder Hum. Mol. Genet. 14 2005 307 318
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 307-318
    • Fernet, M.1    Gribaa, M.2    Salih, M.A.3    Seidahmed, M.Z.4    Hall, J.5    Koenig, M.6
  • 19
    • 1542542679 scopus 로고    scopus 로고
    • Mutation screening of Mre11 complex genes: Indication of RAD50 involvement in breast and ovarian cancer susceptibility
    • K. Heikkinen, S.M. Karppinen, Y. Soini, M. Mäkinen, and R. Winqvist Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility J. Med. Genet. 40 2003 e131 e138
    • (2003) J. Med. Genet. , vol.40
    • Heikkinen, K.1    Karppinen, S.M.2    Soini, Y.3    Mäkinen, M.4    Winqvist, R.5
  • 20
    • 0035906860 scopus 로고    scopus 로고
    • Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase
    • DOI 10.1016/S0092-8674(01)00335-X
    • K.P. Hopfner, A. Karcher, L. Craig, T.T. Woo, J.P. Carney, and J.A. Tainer Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase Cell 105 2001 473 485 (Pubitemid 32520853)
    • (2001) Cell , vol.105 , Issue.4 , pp. 473-485
    • Hopfner, K.-P.1    Karcher, A.2    Craig, L.3    Woo, T.T.4    Carney, J.P.5    Tainer, J.A.6
  • 22
    • 1842431822 scopus 로고    scopus 로고
    • Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex
    • DOI 10.1126/science.1091496
    • J.H. Lee, and T.T. Paull Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex Science 304 2004 93 96 (Pubitemid 38451463)
    • (2004) Science , vol.304 , Issue.5667 , pp. 93-96
    • Lee, J.-H.1    Paull, T.T.2
  • 23
    • 17644409069 scopus 로고    scopus 로고
    • ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
    • DOI 10.1126/science.1108297
    • J.H. Lee, and T.T. Paull ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex Science 308 2005 551 554 (Pubitemid 40570585)
    • (2005) Science , vol.308 , Issue.5721 , pp. 551-554
    • Lee, J.-H.1    Paull, T.T.2
  • 24
    • 0242413320 scopus 로고    scopus 로고
    • Regulation of Mre11/Rad50 by Nbs1: Effects on nucleotide-dependent DNA binding and association with ataxiatelangiectasia-like disorder mutant complexes
    • DOI 10.1074/jbc.M308705200
    • J.H. Lee, R. Ghirlando, V. Bhaskara, M.R. Hoffmeyer, J. Gu, and T.T. Paull Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes J. Biol. Chem. 278 2003 45171 45181 (Pubitemid 37432650)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.46 , pp. 45171-45181
    • Lee, J.-H.1    Ghirlando, R.2    Bhaskara, V.3    Hoffmeyer, M.R.4    Gu, J.5    Paull, T.T.6
  • 25
    • 79956301873 scopus 로고    scopus 로고
    • Crystal structure of the Mre11-Rad50-ATPγS complex: Understanding the interplay between Mre11 and Rad50
    • H.S. Lim, J.S. Kim, Y.B. Park, G.H. Gwon, and Y. Cho Crystal structure of the Mre11-Rad50-ATPγS complex: understanding the interplay between Mre11 and Rad50 Genes Dev. 25 2011 1091 1104
    • (2011) Genes Dev. , vol.25 , pp. 1091-1104
    • Lim, H.S.1    Kim, J.S.2    Park, Y.B.3    Gwon, G.H.4    Cho, Y.5
  • 27
    • 68249116573 scopus 로고    scopus 로고
    • DNA end resection: Many nucleases make light work
    • E.P. Mimitou, and L.S. Symington DNA end resection: many nucleases make light work DNA Repair (Amst.) 8 2009 983 995
    • (2009) DNA Repair (Amst.) , vol.8 , pp. 983-995
    • Mimitou, E.P.1    Symington, L.S.2
  • 28
    • 0032931844 scopus 로고    scopus 로고
    • The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance
    • S. Moreau, J.R. Ferguson, and L.S. Symington The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance Mol. Cell. Biol. 19 1999 556 566 (Pubitemid 29018457)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.1 , pp. 556-566
    • Moreau, S.1    Ferguson, J.R.2    Symington, L.S.3
  • 30
    • 77956302112 scopus 로고    scopus 로고
    • Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae
    • H. Niu, W.H. Chung, Z. Zhu, Y. Kwon, W. Zhao, P. Chi, R. Prakash, C. Seong, D. Liu, and L. Lu Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae Nature 467 2010 108 111
    • (2010) Nature , vol.467 , pp. 108-111
    • Niu, H.1    Chung, W.H.2    Zhu, Z.3    Kwon, Y.4    Zhao, W.5    Chi, P.6    Prakash, R.7    Seong, C.8    Liu, D.9    Lu, L.10
  • 31
    • 0031059866 scopus 로고    scopus 로고
    • Processing of X-ray diffraction data collected in oscillation mode
    • DOI 10.1016/S0076-6879(97)76066-X
    • Z. Otwinowski, and W. Minor Processing of X-ray diffraction data collected in oscillation mode Methods Enzymol. 276 1997 307 326 (Pubitemid 27085611)
    • (1997) Methods in Enzymology , vol.276 , pp. 307-326
    • Otwinowski, Z.1    Minor, W.2
  • 32
    • 61849109768 scopus 로고    scopus 로고
    • Recruitment of Saccharomyces cerevisiae Dnl4-Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domain
    • P.L. Palmbos, D. Wu, J.M. Daley, and T.E. Wilson Recruitment of Saccharomyces cerevisiae Dnl4-Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domain Genetics 180 2008 1809 1819
    • (2008) Genetics , vol.180 , pp. 1809-1819
    • Palmbos, P.L.1    Wu, D.2    Daley, J.M.3    Wilson, T.E.4
  • 33
    • 0032085295 scopus 로고    scopus 로고
    • The 3′ to 5′ exonuclease activity of Mre11 facilitates repair of DNA double-strand breaks
    • T.T. Paull, and M. Gellert The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks Mol. Cell 1 1998 969 979 (Pubitemid 128379258)
    • (1998) Molecular Cell , vol.1 , Issue.7 , pp. 969-979
    • Paull, T.T.1    Gellert, M.2
  • 34
    • 0033563229 scopus 로고    scopus 로고
    • Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
    • T.T. Paull, and M. Gellert Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex Genes Dev. 13 1999 1276 1288 (Pubitemid 29250195)
    • (1999) Genes and Development , vol.13 , Issue.10 , pp. 1276-1288
    • Paull, T.T.1    Gellert, M.2
  • 39
    • 0035929667 scopus 로고    scopus 로고
    • DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50 Mre11 complex
    • K.M. Trujillo, and P. Sung DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50 Mre11 complex J. Biol. Chem. 276 2001 35458 35464
    • (2001) J. Biol. Chem. , vol.276 , pp. 35458-35464
    • Trujillo, K.M.1    Sung, P.2
  • 40
    • 0032555480 scopus 로고    scopus 로고
    • Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
    • DOI 10.1074/jbc.273.34.21447
    • K.M. Trujillo, S.S. Yuan, E.Y. Lee, and P. Sung Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95 J. Biol. Chem. 273 1998 21447 21450 (Pubitemid 28405310)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.34 , pp. 21447-21450
    • Trujillo, K.M.1    Yuan, S.-S.F.2    Lee, E.Y.-H.P.3    Sung, P.4
  • 42
    • 0032567108 scopus 로고    scopus 로고
    • Complex formation and functional versatility of Mre11 of budding yeast in recombination
    • T. Usui, T. Ohta, H. Oshiumi, J. Tomizawa, H. Ogawa, and T. Ogawa Complex formation and functional versatility of Mre11 of budding yeast in recombination Cell 95 1998 705 716 (Pubitemid 28544131)
    • (1998) Cell , vol.95 , Issue.5 , pp. 705-716
    • Usui, T.1    Ohta, T.2    Oshiumi, H.3    Tomizawa, J.-I.4    Ogawa, H.5    Ogawa, T.6
  • 46
    • 33845604556 scopus 로고    scopus 로고
    • DNA double-strand break repair: All's well that ends well
    • DOI 10.1146/annurev.genet.40.110405.090451
    • C. Wyman, and R. Kanaar DNA double-strand break repair: all's well that ends well Annu. Rev. Genet. 40 2006 363 383 (Pubitemid 44956790)
    • (2006) Annual Review of Genetics , vol.40 , pp. 363-383
    • Wyman, C.1    Kanaar, R.2
  • 47
    • 0030749867 scopus 로고    scopus 로고
    • Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells
    • DOI 10.1093/nar/25.15.2985
    • Y. Xiao, and D.T. Weaver Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells Nucleic Acids Res. 25 1997 2985 2991 (Pubitemid 27331390)
    • (1997) Nucleic Acids Research , vol.25 , Issue.15 , pp. 2985-2991
    • Xiao, Y.1    Weaver, D.T.2
  • 48
    • 20744436198 scopus 로고    scopus 로고
    • ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1
    • DOI 10.1128/MCB.25.13.5363-5379.2005
    • Z. You, C. Chahwan, J. Bailis, T. Hunter, and P. Russell ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1 Mol. Cell. Biol. 25 2005 5363 5379 (Pubitemid 40853574)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.13 , pp. 5363-5379
    • You, Z.1    Chahwan, C.2    Bailis, J.3    Hunter, T.4    Russell, P.5


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