Activating cannabinoid receptor 2 alleviates pathogenesis of experimental autoimmune encephalomyelitis via activation of autophagy and inhibiting NLRP3 inflammasome

CNS Neuroscience and Therapeutics

Volumn 20, Issue 12, 2014, Pages 1021-1028

  Shao, Bo Zong ^a   Wei, Wei ^b   Ke, Ping ^a   Xu, Zhe Qi ^a   Zhou, Jv Xiang ^a   Liu, Chong ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b INSTITUTE OF PLANT PROTECTION AND MICROBIOLOGY   (China)

Author keywords

EAE; Autophagy; Cannabinoid receptor 2; NLRP3 inflammasome

Indexed keywords

4 [4 (1,1 DIMETHYLHEPTYL) 2,6 DIMETHOXYPHENYL] 6,6 DIMETHYLBICYCLO[3.1.1]HEPT 2 EN 2 YLMETHANOL; AUTOPHAGY PROTEIN 5; BECLIN 1; CANNABINOID 2 RECEPTOR; CRYOPYRIN; ENZYME PRECURSOR; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA; PROCASPASE 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ATG5 PROTEIN, MOUSE; CANNABINOID; CANNABINOID RECEPTOR AGONIST; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; CNR2 PROTEIN, MOUSE; LIPOPOLYSACCHARIDE; MAP1LC3 PROTEIN, MOUSE; MICROTUBULE ASSOCIATED PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; ENZYME ACTIVATION; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; GENE DELETION; HISTOPATHOLOGY; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; LIGHT CHAIN; MICROGLIA; MOUSE; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SPINAL CORD; ANIMAL; C57BL MOUSE; CELL CULTURE; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; AUTOPHAGY; CANNABINOID RECEPTOR AGONISTS; CANNABINOIDS; CARRIER PROTEINS; CASPASE 1; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENE EXPRESSION REGULATION; INFLAMMATION; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; MICROTUBULE-ASSOCIATED PROTEINS; RECEPTOR, CANNABINOID, CB2; SPINAL CORD;

EID: 84911375796     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12349     Document Type: Article

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