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Volumn 18, Issue 11, 2012, Pages 909-917

Fasudil Ameliorates Disease Progression in Experimental Autoimmune Encephalomyelitis, Acting Possibly Through Antiinflammatory Effect

Author keywords

Antiinflammation; Experimental autoimmune encephalomyelitis; Fasudil

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CANNABINOID 2 RECEPTOR; FASUDIL; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; NERVE GROWTH FACTOR; SYNAPTOTAGMIN I; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

EID: 84868195009     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12002     Document Type: Article
Times cited : (46)

References (51)
  • 1
    • 80053482080 scopus 로고    scopus 로고
    • Evidence for viral etiology of multiple sclerosis
    • Tselis A. Evidence for viral etiology of multiple sclerosis. Semin Neurol 2011;31:307-316.
    • (2011) Semin Neurol , vol.31 , pp. 307-316
    • Tselis, A.1
  • 2
    • 78650172976 scopus 로고    scopus 로고
    • Inflammation, demyelination, and degeneration - recent insights from MS pathology
    • Stadelmann C, Wegner C, Brück W. Inflammation, demyelination, and degeneration - recent insights from MS pathology. Biochim Biophys Acta 2011;1812:275-282.
    • (2011) Biochim Biophys Acta , vol.1812 , pp. 275-282
    • Stadelmann, C.1    Wegner, C.2    Brück, W.3
  • 3
    • 0031726374 scopus 로고    scopus 로고
    • The epitope spreading cascade during progression of experimental autoimmune encephalomyelitis and multiple sclerosis
    • Tuohy VK, Yu M, Yin L, et al. The epitope spreading cascade during progression of experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol Rev 1998;164:93-100.
    • (1998) Immunol Rev , vol.164 , pp. 93-100
    • Tuohy, V.K.1    Yu, M.2    Yin, L.3
  • 4
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 2005;23:683-747.
    • (2005) Annu Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 6
    • 1142297518 scopus 로고    scopus 로고
    • Inhibition of Rho-kinase protects the heart against ischemia/reperfusion injury
    • Bao W, Hu E, Tao L, et al. Inhibition of Rho-kinase protects the heart against ischemia/reperfusion injury. Cardiovasc Res 2004;61:548-558.
    • (2004) Cardiovasc Res , vol.61 , pp. 548-558
    • Bao, W.1    Hu, E.2    Tao, L.3
  • 7
    • 48249153495 scopus 로고    scopus 로고
    • Rho-kinase signalling mediates endotoxin hypersensitivity after partial hepatectomy
    • Slotta JE, Laschke MW, Menger MD, Thorlacius H. Rho-kinase signalling mediates endotoxin hypersensitivity after partial hepatectomy. Br J Surg 2008;95:976-984.
    • (2008) Br J Surg , vol.95 , pp. 976-984
    • Slotta, J.E.1    Laschke, M.W.2    Menger, M.D.3    Thorlacius, H.4
  • 8
    • 81155139675 scopus 로고    scopus 로고
    • Pretreatment of Rho kinase inhibitor inhibits systemic inflammation and prevents endotoxin-induced acute lung injury in mice
    • Ding RY, Zhao DM, Zhang ZD, Guo RX, Ma XC. Pretreatment of Rho kinase inhibitor inhibits systemic inflammation and prevents endotoxin-induced acute lung injury in mice. J Surg Res 2011;171:e209-e214.
    • (2011) J Surg Res , vol.171
    • Ding, R.Y.1    Zhao, D.M.2    Zhang, Z.D.3    Guo, R.X.4    Ma, X.C.5
  • 9
    • 77952271882 scopus 로고    scopus 로고
    • Vasospasm after aneurysmal subarachnoid hemorrhage: recent advances in endovascular management
    • Pierot L, Aggour M, Moret J. Vasospasm after aneurysmal subarachnoid hemorrhage: recent advances in endovascular management. Curr Opin Crit Care 2010;16:110-116.
    • (2010) Curr Opin Crit Care , vol.16 , pp. 110-116
    • Pierot, L.1    Aggour, M.2    Moret, J.3
  • 10
    • 26444518165 scopus 로고    scopus 로고
    • Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection
    • Rikitake Y, Kim HH, Huang Z, et al. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke 2005;36:2251-2257.
    • (2005) Stroke , vol.36 , pp. 2251-2257
    • Rikitake, Y.1    Kim, H.H.2    Huang, Z.3
  • 11
    • 0033946174 scopus 로고    scopus 로고
    • Protein kinase inhibition by fasudil hydrochloride promotes neurological recovery after spinal cord injury in rats
    • Hara M, Takayasu M, Watanabe K, et al. Protein kinase inhibition by fasudil hydrochloride promotes neurological recovery after spinal cord injury in rats. J Neurosurg 2000;93:94-101.
    • (2000) J Neurosurg , vol.93 , pp. 94-101
    • Hara, M.1    Takayasu, M.2    Watanabe, K.3
  • 12
    • 84860154968 scopus 로고    scopus 로고
    • Aorta-derived mesoangioblasts differentiate into the oligodendrocytes by inhibition of the Rho kinase signaling pathway
    • Wang L, Kamath A, Frye J, Iwamoto GA, Chun JL, Berry SE. Aorta-derived mesoangioblasts differentiate into the oligodendrocytes by inhibition of the Rho kinase signaling pathway. Stem Cells Dev 2012;21:1069-1089.
    • (2012) Stem Cells Dev , vol.21 , pp. 1069-1089
    • Wang, L.1    Kamath, A.2    Frye, J.3    Iwamoto, G.A.4    Chun, J.L.5    Berry, S.E.6
  • 14
    • 18944372230 scopus 로고    scopus 로고
    • Rho kinase, a promising drug target for neurological disorders
    • Mueller BK, Mack H, Teusch N. Rho kinase, a promising drug target for neurological disorders. Nat Rev Drug Discov 2005;4:387-398.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 387-398
    • Mueller, B.K.1    Mack, H.2    Teusch, N.3
  • 15
    • 84862928989 scopus 로고    scopus 로고
    • Saturated fatty acids activate microglia via Toll-like receptor 4/NF-κB signalling
    • Wang Z, Liu D, Wang F, et al. Saturated fatty acids activate microglia via Toll-like receptor 4/NF-κB signalling. Br J Nutr 2012;107:229-241.
    • (2012) Br J Nutr , vol.107 , pp. 229-241
    • Wang, Z.1    Liu, D.2    Wang, F.3
  • 16
    • 79251598329 scopus 로고    scopus 로고
    • Quercetin regulates oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR-NF-κB signaling pathway
    • Bhaskar S, Shalini V, Helen A. Quercetin regulates oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR-NF-κB signaling pathway. Immunobiology 2011;216:367-373.
    • (2011) Immunobiology , vol.216 , pp. 367-373
    • Bhaskar, S.1    Shalini, V.2    Helen, A.3
  • 18
    • 70350558453 scopus 로고    scopus 로고
    • Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord
    • Kigerl KA, Gensel JC, Ankeny DP, Alexander JK, Donnelly DJ, Popovich PG. Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J Neurosci 2009;29:13435-13444.
    • (2009) J Neurosci , vol.29 , pp. 13435-13444
    • Kigerl, K.A.1    Gensel, J.C.2    Ankeny, D.P.3    Alexander, J.K.4    Donnelly, D.J.5    Popovich, P.G.6
  • 21
    • 78349240662 scopus 로고    scopus 로고
    • NF-kappaB signaling in neurite growth and neuronal survival
    • Teng FY, Tang BL. NF-kappaB signaling in neurite growth and neuronal survival. Rev Neurosci 2010;21:299-313.
    • (2010) Rev Neurosci , vol.21 , pp. 299-313
    • Teng, F.Y.1    Tang, B.L.2
  • 22
    • 79952092131 scopus 로고    scopus 로고
    • Multiple roles for RhoA during T cell transendothelial migration
    • Heasman SJ, Ridley AJ. Multiple roles for RhoA during T cell transendothelial migration. Small Gtpases 2010;1:174-179.
    • (2010) Small Gtpases , vol.1 , pp. 174-179
    • Heasman, S.J.1    Ridley, A.J.2
  • 24
    • 77951237069 scopus 로고    scopus 로고
    • Down-regulation of NF-kappaB led to up-regulation of NGF production in mouse osteoblasts
    • Mogi M, Kondo A. Down-regulation of NF-kappaB led to up-regulation of NGF production in mouse osteoblasts. J Immunoassay Immunochem 2010;31:92-101.
    • (2010) J Immunoassay Immunochem , vol.31 , pp. 92-101
    • Mogi, M.1    Kondo, A.2
  • 25
    • 84855992548 scopus 로고    scopus 로고
    • Constitutive activity of NF-kappa B in myeloid cells drives pathogenicity of monocytes and macrophages during autoimmune neuroinflammation
    • Ellrichmann G, Thöne J, Lee DH, Rupec RA, Gold R, Linker RA. Constitutive activity of NF-kappa B in myeloid cells drives pathogenicity of monocytes and macrophages during autoimmune neuroinflammation. J Neuroinflammation 2012;9:15.
    • (2012) J Neuroinflammation , vol.9 , pp. 15
    • Ellrichmann, G.1    Thöne, J.2    Lee, D.H.3    Rupec, R.A.4    Gold, R.5    Linker, R.A.6
  • 26
    • 82255191977 scopus 로고    scopus 로고
    • TLR-dependent T cell activation in autoimmunity
    • Mills KH. TLR-dependent T cell activation in autoimmunity. Nat Rev Immunol 2011;11:807-822.
    • (2011) Nat Rev Immunol , vol.11 , pp. 807-822
    • Mills, K.H.1
  • 27
    • 75749133624 scopus 로고    scopus 로고
    • Immune cell entry to central nervous system-current understanding and prospective therapeutic targets
    • Prendergast CT, Anderton SM. Immune cell entry to central nervous system-current understanding and prospective therapeutic targets. Endocr Metab Immune Disord Drug Targets 2009;9:315-327.
    • (2009) Endocr Metab Immune Disord Drug Targets , vol.9 , pp. 315-327
    • Prendergast, C.T.1    Anderton, S.M.2
  • 28
    • 77955659717 scopus 로고    scopus 로고
    • Neurodegeneration in autoimmune CNS inflammation
    • Herz J, Zipp F, Siffrin V. Neurodegeneration in autoimmune CNS inflammation. Exp Neurol 2010;225:9-17.
    • (2010) Exp Neurol , vol.225 , pp. 9-17
    • Herz, J.1    Zipp, F.2    Siffrin, V.3
  • 29
    • 73349118789 scopus 로고    scopus 로고
    • Innate immune CD11b+Gr-1+ cells, suppressor cells, affect the immune response during Theiler's virus-induced demyelinating disease
    • Bowen JL, Olson JK. Innate immune CD11b+Gr-1+ cells, suppressor cells, affect the immune response during Theiler's virus-induced demyelinating disease. J Immunol 2009;183:6971-6980.
    • (2009) J Immunol , vol.183 , pp. 6971-6980
    • Bowen, J.L.1    Olson, J.K.2
  • 30
    • 78651079511 scopus 로고    scopus 로고
    • Naïve blood monocytes suppress T-cell function. A possible mechanism for protection from autoimmunity
    • Slaney CY, Toker A, La FA, Backstrom BT, Harper JL. Naïve blood monocytes suppress T-cell function. A possible mechanism for protection from autoimmunity. Immunol Cell Biol 2011;89:7-13.
    • (2011) Immunol Cell Biol , vol.89 , pp. 7-13
    • Slaney, C.Y.1    Toker, A.2    La, F.A.3    Backstrom, B.T.4    Harper, J.L.5
  • 31
    • 38449100026 scopus 로고    scopus 로고
    • CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis
    • Zhu B, Bando Y, Xiao S. CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis. J Immunol 2007;179:5228-5237.
    • (2007) J Immunol , vol.179 , pp. 5228-5237
    • Zhu, B.1    Bando, Y.2    Xiao, S.3
  • 32
    • 23444456772 scopus 로고    scopus 로고
    • Regulation of immune responses by L-arginine metabolism
    • Bronte V, Zanovello P. Regulation of immune responses by L-arginine metabolism. Nat Rev Immunol 2005;5:641-654.
    • (2005) Nat Rev Immunol , vol.5 , pp. 641-654
    • Bronte, V.1    Zanovello, P.2
  • 33
    • 78650474985 scopus 로고    scopus 로고
    • Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13
    • Highfill SL, Rodriguez PC, Zhou Q, et al. Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13. Blood 2010;116:5738-5747.
    • (2010) Blood , vol.116 , pp. 5738-5747
    • Highfill, S.L.1    Rodriguez, P.C.2    Zhou, Q.3
  • 34
    • 1842536392 scopus 로고    scopus 로고
    • Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major
    • Kropf P, Freudenberg MA, Modolell M, et al. Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major. Infect Immun 2004;72:1920-1928.
    • (2004) Infect Immun , vol.72 , pp. 1920-1928
    • Kropf, P.1    Freudenberg, M.A.2    Modolell, M.3
  • 35
    • 79955723632 scopus 로고    scopus 로고
    • Myeloid derived suppressor cells in human diseases
    • Greten TF, Manns MP, Korangy F. Myeloid derived suppressor cells in human diseases. Int Immunopharmacol 2011;11:802-807.
    • (2011) Int Immunopharmacol , vol.11 , pp. 802-807
    • Greten, T.F.1    Manns, M.P.2    Korangy, F.3
  • 36
    • 80053162222 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells limit the inflammation by promoting T lymphocyte apoptosis in the spinal cord of a murine model of multiple sclerosis
    • Moliné-Velázquez V, Cuervo H, Ortega MC, Clemente D, de Castro F. Myeloid-derived suppressor cells limit the inflammation by promoting T lymphocyte apoptosis in the spinal cord of a murine model of multiple sclerosis. Brain Pathol 2011;21:678-691.
    • (2011) Brain Pathol , vol.21 , pp. 678-691
    • Moliné-Velázquez, V.1    Cuervo, H.2    Ortega, M.C.3    Clemente, D.4    de Castro, F.5
  • 37
    • 80051547684 scopus 로고    scopus 로고
    • Arginase I attenuates inflammatory cytokine secretion induced by lipopolysaccharide in vascular smooth muscle cells
    • Wang XP, Chen YG, Qin WD, et al. Arginase I attenuates inflammatory cytokine secretion induced by lipopolysaccharide in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2011;31:1853-1860.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 1853-1860
    • Wang, X.P.1    Chen, Y.G.2    Qin, W.D.3
  • 39
    • 34147165471 scopus 로고    scopus 로고
    • Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells
    • Maresz K, Pryce G, Ponomarev ED, et al. Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. Nat Med 2007;13:492-497.
    • (2007) Nat Med , vol.13 , pp. 492-497
    • Maresz, K.1    Pryce, G.2    Ponomarev, E.D.3
  • 40
    • 45149123400 scopus 로고    scopus 로고
    • The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosis
    • Palazuelos J, Davoust N, Julien B, et al. The CB(2) cannabinoid receptor controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosis. J Biol Chem 2008;283:13320-13329.
    • (2008) J Biol Chem , vol.283 , pp. 13320-13329
    • Palazuelos, J.1    Davoust, N.2    Julien, B.3
  • 41
    • 0035676046 scopus 로고    scopus 로고
    • Cannabinoid-mediated inhibition of inducible nitric oxide production by rat microglial cells: evidence for CB1 receptor participation
    • Cabral GA, Harmon KN, Carlisle SJ. Cannabinoid-mediated inhibition of inducible nitric oxide production by rat microglial cells: evidence for CB1 receptor participation. Adv Exp Med Biol 2001;493:207-214.
    • (2001) Adv Exp Med Biol , vol.493 , pp. 207-214
    • Cabral, G.A.1    Harmon, K.N.2    Carlisle, S.J.3
  • 42
    • 0037085572 scopus 로고    scopus 로고
    • Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures
    • Molina-Holgado F, Molina-Holgado E, Guaza C, Rothwell NJ. Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures. J Neurosci Res 2002;67:829-836.
    • (2002) J Neurosci Res , vol.67 , pp. 829-836
    • Molina-Holgado, F.1    Molina-Holgado, E.2    Guaza, C.3    Rothwell, N.J.4
  • 44
    • 33644804271 scopus 로고    scopus 로고
    • The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids
    • Pertwee RG. The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids. AAPS J 2005;7:E625-E654.
    • (2005) AAPS J , vol.7
    • Pertwee, R.G.1
  • 45
    • 0242304878 scopus 로고    scopus 로고
    • Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
    • Pryce G, Ahmed Z, Hankey DJ, et al. Cannabinoids inhibit neurodegeneration in models of multiple sclerosis. Brain 2003;126:2191-2202.
    • (2003) Brain , vol.126 , pp. 2191-2202
    • Pryce, G.1    Ahmed, Z.2    Hankey, D.J.3
  • 46
    • 33947583201 scopus 로고    scopus 로고
    • Excitotoxicity in a chronic model of multiple sclerosis: neuroprotective effects of cannabinoids through CB1 and CB2 receptor activation
    • Docagne F, Muneton V, Clemente D, et al. Excitotoxicity in a chronic model of multiple sclerosis: neuroprotective effects of cannabinoids through CB1 and CB2 receptor activation. Mol Cell Neurosci 2007;34:551-561.
    • (2007) Mol Cell Neurosci , vol.34 , pp. 551-561
    • Docagne, F.1    Muneton, V.2    Clemente, D.3
  • 47
    • 37749034365 scopus 로고    scopus 로고
    • Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis
    • Croxford JL, Pryce G, Jackson SJ, et al. Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis. J Neuroimmunol 2008;193:120-129.
    • (2008) J Neuroimmunol , vol.193 , pp. 120-129
    • Croxford, J.L.1    Pryce, G.2    Jackson, S.J.3
  • 48
    • 41749106682 scopus 로고    scopus 로고
    • BDNF impairment in the hippocampus is related to enhanced despair behavior in CB1 knockout mice
    • Aso E, Ozaita A, Valdizán EM, et al. BDNF impairment in the hippocampus is related to enhanced despair behavior in CB1 knockout mice. J Neurochem 2008;105:565-572.
    • (2008) J Neurochem , vol.105 , pp. 565-572
    • Aso, E.1    Ozaita, A.2    Valdizán, E.M.3
  • 49
    • 18844450416 scopus 로고    scopus 로고
    • In vivo up-regulation of brain-derived neurotrophic factor in specific brain areas by chronic exposure to Delta-tetrahydrocannabinol
    • Butovsky E, Juknat A, Goncharov I, et al. In vivo up-regulation of brain-derived neurotrophic factor in specific brain areas by chronic exposure to Delta-tetrahydrocannabinol. J Neurochem 2005;93:802-811.
    • (2005) J Neurochem , vol.93 , pp. 802-811
    • Butovsky, E.1    Juknat, A.2    Goncharov, I.3
  • 50
    • 59949096898 scopus 로고    scopus 로고
    • Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans
    • D'Souza DC, Pittman B, Perry E, Simen A. Preliminary evidence of cannabinoid effects on brain-derived neurotrophic factor (BDNF) levels in humans. Psychopharmacology 2009;202:569-578.
    • (2009) Psychopharmacology , vol.202 , pp. 569-578
    • D'Souza, D.C.1    Pittman, B.2    Perry, E.3    Simen, A.4
  • 51
    • 1842633560 scopus 로고    scopus 로고
    • Involvement of brain-derived neurotrophic factor in cannabinoid receptor-dependent protection against excitotoxicity
    • Khaspekov LG, Brenz Verca MS, Frumkina LE, Hermann H, Marsicano G, Lutz B. Involvement of brain-derived neurotrophic factor in cannabinoid receptor-dependent protection against excitotoxicity. Eur J Neurosci 2004;19:1691-1698.
    • (2004) Eur J Neurosci , vol.19 , pp. 1691-1698
    • Khaspekov, L.G.1    Brenz Verca, M.S.2    Frumkina, L.E.3    Hermann, H.4    Marsicano, G.5    Lutz, B.6


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