Hu antigen R (HuR) is a positive regulator of the RNA-binding proteins TDP-43 and FUS/TLS: Implications for amyotrophic lateral sclerosis

Journal of Biological Chemistry

Volumn 289, Issue 46, 2014, Pages 31792-31804

  Lu, Liang ^a,b,f   Zheng, Lei ^a   Si, Ying ^a   Luo, Wenyi ^a   Dujardin, Gwendal ^g   Kwan, Thaddaeus ^a   Potochick, Nicholas R ^d   Thompson, Sunnie R ^d   Schneider, David A ^e   King, Peter H ^a,b,c,f  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d University of Alabama at Birmingham   (United States)

^e UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^f BIRMINGHAM VA MEDICAL CENTER   (United States)

^g UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

GENE EXPRESSION; NEURODEGENERATIVE DISEASES; NEURONS; PROTEINS;

AMYOTROPHIC LATERAL SCLEROSIS; CONDITIONED MEDIUM; MOLECULAR PROCESS; POST-TRANSCRIPTIONAL GENE REGULATION; REGULATORY ELEMENTS; RNA-BINDING PROTEIN; TRANSLATIONAL EFFICIENCIES; UNTRANSLATED REGIONS;

RNA;

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; FUSED IN SARCOMA PROTEIN; HU ANTIGEN R; RNA BINDING PROTEIN; TAR DNA BINDING PROTEIN; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; CFTR PROTEIN, HUMAN; CULTURE MEDIUM; DNA BINDING PROTEIN; ELAVL1 PROTEIN, HUMAN; HU ANTIGEN; PROTEIN TDP-43; RNA;

3' UNTRANSLATED REGION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; ASTROCYTE; AUTOREGULATION; BINDING AFFINITY; BIOTINYLATION; CELL VIABILITY; CONTROLLED STUDY; DENSITOMETRY; IMMUNOPRECIPITATION; MOTONEURON; MOUSE; NONHUMAN; OPEN READING FRAME; PHENOTYPE; POLYADENYLATION; POLYSOME; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA ISOLATION; RNA PROCESSING; ANIMAL; ANOXIA; CELL LINE; CELL SURVIVAL; CHEMISTRY; CULTURE MEDIUM; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; TUMOR CELL LINE;

3' UNTRANSLATED REGIONS; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANOXIA; ASTROCYTES; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CULTURE MEDIA, CONDITIONED; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS; HUMANS; MICE; MOTOR NEURONS; PHENOTYPE; RNA; RNA-BINDING PROTEIN FUS;

EID: 84911086226     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.573246     Document Type: Article

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