A hairpin-like structure within an AU-rich mRNA-destabilizing element regulates trans-factor binding selectivity and mRNA decay kinetics

Journal of Biological Chemistry

Volumn 280, Issue 23, 2005, Pages 22406-22417

  Fialcowitz, Elizabeth J ^a   Brewer, Brandy Y ^a   Keenan, Bridget P ^a   Wilson, Gerald M ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; GENETIC ENGINEERING; MOLECULAR BIOLOGY; MOLECULAR STRUCTURE; PROTEINS; THERMAL EFFECTS;

BINDING AFFINITY; BINDING PROTEINS; DESTABILIZATION; TARGETED TRANSCRIPTS;

RNA;

HEAT SHOCK PROTEIN 70; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D; MESSENGER RNA; PROTEIN P37; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VIVO STUDY; MUTATION; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN METABOLISM; PROTEIN STABILITY; PROTEIN STRUCTURE;

BASE SEQUENCE; CATIONS; COMPUTATIONAL BIOLOGY; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENCE RESONANCE ENERGY TRANSFER; GLUTATHIONE TRANSFERASE; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN D; HSP70 HEAT-SHOCK PROTEINS; HUMANS; KINETICS; MAGNESIUM; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; NUCLEIC ACID CONFORMATION; PHYLOGENY; PROTEIN BINDING; PROTEIN FOLDING; RECOMBINANT PROTEINS; RNA; RNA, MESSENGER; SEQUENCE HOMOLOGY, NUCLEIC ACID; TEMPERATURE; TIME FACTORS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

MAMMALIA;

EID: 20444498254     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M500618200     Document Type: Article

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