KSRP: A checkpoint for inflammatory cytokine production in astrocytes

GLIA

Volumn 60, Issue 11, 2012, Pages 1773-1784

  Li, Xuelin ^a   Lin, Wei Jye ^f   Chen, Ching Yi ^b   Si, Ying ^a   Zhang, Xiaowen ^a   Lu, Liang ^a,e   Suswam, Esther ^a   Zheng, Lei ^a   King, Peter H ^a,c,d,e  

^a The University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^e BIRMINGHAM VA MEDICAL CENTER   (United States)

^f MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

AU rich element; IL 1 ; RNA stability; TNF

Indexed keywords

ADENINE DERIVATIVE; ADENYLATE URIDYLATE RICH ELEMENT; INTERLEUKIN 1BETA; KH TYPE SPLICING REGULATORY PROTEIN; MESSENGER RNA; REGULATOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; GENE EXPRESSION; GENOTYPE; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; ASTROCYTES; CELL DEATH; CELL MOVEMENT; CYTOKINES; GENE EXPRESSION REGULATION; INFLAMMATION; INTERLEUKIN-1BETA; MICE; MICE, KNOCKOUT; NEURONS; RNA-BINDING PROTEINS; TRANS-ACTIVATORS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84865862707     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22396     Document Type: Article

References (55)

1. Allan SM, Tyrrell PJ, Rothwell NJ. 2005. Interleukin-1 and neuronal injury. Nat Rev Immunol 5: 629-640.
2. Aoki N, Kimura Y, Kimura S, Nagato T, Azumi M, Kobayashi H, Sato K, Tateno M. 2009. Expression and functional role of MDL-1 (CLEC5A) in mouse myeloid lineage cells. J Leukocyte Biol 85: 508-517.
3. Bakker ABH, Baker E, Sutherland GR, Phillips JH, Lanier LL. 1999. Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells. Proc Natl Acad Sci USA 96: 9792-9796.
4. Benjamin LR, Chung H-J, Sanford S, Kouzine F, Liu J, Levens D. 2008. Hierarchical mechanisms build the DNA-binding specificity of FUSE binding protein. Proc Natl Acad Sci USA 105: 18296-18301.
5. Blackburn D, Sargsyan S, Monk PN, Shaw PJ. 2009. Astrocyte function and role in motor neuron disease: A future therapeutic target? GLIA 57: 1251-1264.
6. Bouchon A, Facchetti F, Weigand MA, Colonna M. 2001. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 410: 1103-1107.
7. Brown CY, Lagnado CA, Vadas MA, Goodall GJ. 1996. Differential regulation of the stability of cytokine mRNAs in lipopolysaccharide-activated blood monocytes in response to interleukin-10. J Biol Chem 271: 20108-20112.
8. Chen S-T, Lin Y-L, Huang M-T, Wu M-F, Cheng S-C, Lei H-Y, Lee C-K, Chiou T-W, Wong C-H, Hsieh S-L. 2008. CLEC5A is critical for dengue-virus-induced lethal disease. Nature 453: 672-676.
9. Chen Y-L, Huang Y-L, Lin N-Y, Chen H-C, Chiu W-C, Chang C-J. 2006. Differential regulation of ARE-mediated TNFα and IL-1β mRNA stability by lipopolysaccharide in RAW264.7 cells. Biochem Biophys Res Commun 346: 160-168.
10. Chuanyu L, Rui Z, Kai G, Zheng W, Michael Yaoyao Y, Lok Ting L, Dehua C, Albert Cheung Hoi Y. 2011. Astrocytes: Implications for neuroinflammatory pathogenesis of Alzheimer's disease. Curr Alzheimer Res 8: 67-80.
11. Chung HJ, Liu J, Dundr M, Nie Z, Sanford S, Levens D. 2006. FBPs are calibrated molecular tools to adjust gene expression. Mol Cell Biol 26: 6584-6597.
12. Danckwardt S, Gantzert A-S, Macher-Goeppinger S, Probst HC, Gentzel M, Wilm M, Gröne H-J, Schirmacher P, Hentze MW, Kulozik AE. 2011. p38 MAPK controls prothrombin expression by regulated RNA 3′ end processing. Mol Cell 41: 298-310.
13. Davis-Smyth T, Duncan RC, Zheng T, Michelotti G, Levens D. 1996. The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators. J Biol Chem 271: 31679-31687.
14. Dhamija S, Kuehne N, Winzen R, Doerrie A, Dittrich-Breiholz O, Thakur BK, Kracht M, Holtmann H. 2011. Interleukin-1 activates synthesis of interleukin-6 by interfering with a KH-type splicing regulatory protein (KSRP)-dependent translational silencing mechanism. J Biol Chem 286: 33279-33288.
15. Ding Q, Stewart J, Prince CW, Chang P-L, Trikha M, Han X, Grammer JR, Gladson CL. 2002. Promotion of malignant astrocytoma cell migration by osteopontin expressed in the normal brain. Cancer Res 62: 5336-5343.
16. Dong Y, Benveniste EN. 2001. Immune function of astrocytes. GLIA 36: 180-190.
17. Dorf ME, Berman MA, Tanabe S, Heesen M, Luo Y. 2000. Astrocytes express functional chemokine receptors. J Neuroimmunol 111(1-2): 109-121.
18. Dreyfuss G, Matunis MJ, Pinol-Roma S, Burd CG. 1993. hnRNP proteins and the biogenesis of mRNA. Annu Rev Biochem 62: 289-321.
19. Duncan R, Bazar L, Michelotti G, Tomonaga T, Krutzsch H, Avigan M, Levens D. 1994. A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif. Genes Dev 8: 465-480.
20. Duncan R, Collins I, Tomonaga T, Zhang T, Levens D. 1996. A unique transactivation sequence motif is found in the carboxyl- terminal domain of the single-strand-binding protein FBP. Mol Cell Biol 16: 2274-2282.
21. Faber-Elman A, Lavie V, Schvartz I, Shaltiel S, Schwartz M. 1995. Vitronectin overrides a negative effect of TNF-alpha on astrocyte migration. FASEB J 9: 1605-1613.
22. Gabay C, Lamacchia C, Palmer G. 2010. IL-1 pathways in inflammation and human diseases. Nat Rev Rheumatol 6: 232-241.
23. Gherzi R, Chen CY, Trabucchi M, Ramos A, Briata P. 2010. The role of KSRP in mRNA decay and microRNA precursor maturation. Wiley Interdisciplinary Reviews-RNA 1: 230-239.
24. Graham JR, Hendershott MC, Terragni J, Cooper GM. 2010. mRNA degradation plays a significant role in the program of gene expression regulated by phosphatidylinositol 3-kinase signaling. Mol Cell Biol 30: 5295-5305.
25. Heesen M, Tanabe S, Berman MA, Yoshizawa I, Luo Y, Kim RJ, Post TW, Gerard C, Dorf ME. 1996. Mouse astrocytes respond to the chemokines MCP-1 and KC, but reverse transcriptase-polymerase chain reaction does not detect mRNA for the KC or new MCP-1 receptor. JNeurosci Res 45: 382-391.
26. Hosoda H, Tamura H, Kida S, Nagaoka I. 2011. Transcriptional regulation of mouse TREM-1 gene in RAW264.7 macrophage-like cells. Life Sci 89(3-4): 115-122.
27. Kaltschmidt B, Uherek M, Wellmann H, Volk B, Kaltschmidt C. 1999. Inhibition of NF-κB potentiates amyloid β-mediated neuronal apoptosis. Proc Natl Acad Sci USA 96: 9409-9414.
28. King PH. 1996. Cloning the 5′ flanking sequence of Hel-N1: Evidence for positive regulatory elements governing cell-specific transcription. Brain Res 723(1, 2): 141-147.
29. Lieberman AP, Pitha PM, Shin HS, Shin ML. 1989. Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus. Proc Natl Acad Sci USA 86: 6348-6352.
30. Lin W-J, Duffy A, Chen C-Y. 2007. Localization of AU-rich element-containing mRNA in cytoplasmic granules containing exosome subunits. J Biol Chem 282: 19958-19968.
31. Lin WJ, Zheng X, Lin CC, Tsao J, Zhu X, Cody JJ, Coleman JM, Gherzi R, Luo M, Townes TM, et al. 2011. Posttranscriptional control of type I interferon genes by KSRP in the innate immune response against viral infection. Mol Cell Biol 31: 3196-207.
32. Lindsten T, June CH, Ledbetter JA, Stella G, Thompson CB. 1989. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244: 339-343.
33. Liu J, He L, Collins I, Ge H, Libutti D, Li J, Egly J-M, Levens D. 2000. The FBP interacting repressor targets TFIIH to inhibit activated transcription. Mol Cell 5: 331-341.
34. Lu L, Wang S, Zheng L, Li X, Suswam EA, Zhang X, Wheeler CG, Nabors LB, Filippova N, King PH. 2009. Amyotrophic lateral sclerosis-linked mutant SOD1 sequesters Hu antigen R (HuR) and TIA-1 related protein (TIAR): Implications for impaired posttranscriptional regulation of vascular endothelial growth factor. J Biol Chem 284: 33989-33998.
35. Malz M, Weber A, Singer S, Riehmer V, Bissinger M, Riener MO, Longerich T, Soll C, Vogel A, Angel P, et al. 2009. Overexpression of far upstream element binding proteins: A mechanism regulating proliferation and migration in liver cancer cells. Hepatology 50: 1130-1139.
36. Ming W, Bersani L, Mantovani A. 1987. Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes. J Immunol 138: 1469-1474.
37. Morrison BE, Majdzadeh N, Zhang X, Lyles A, Bassel-Duby R, Olson EN, D'Mello SR. 2006. Neuroprotection by Histone Deacetylase-Related Protein. Mol Cell Biol 26: 3550-3564.
38. Nabors LB, Suswam E, Huang Y, Yang X, Johnson MJ, King PH. 2003. Tumor necrosis factor-α induces angiogenic factor up-regulation in malignant glioma cells: A role for RNA stabilization and HuR. Cancer Res 63: 4181-4187.
39. Park PH, Huang H, McMullen MR, Mandal P, Sun L, Nagy LE. 2008. Suppression of lipopolysaccharide-stimulated tumor necrosis factor-alpha production by adiponectin is mediated by transcriptional and post-transcriptional mechanisms. J Biol Chem 283: 26850-26858.
40. Pautz A, Art J, Hahn S, Nowag S, Voss C, Kleinert H. 2010 Regulation of the expression of inducible nitric oxide synthase. Nitric Oxide-Biol Ch 23: 75-93.
41. Qin H, Niyongere SA, Lee SJ, Baker BJ, Benveniste EN. 2008. Expression and functional significance of SOCS-1 and SOCS-3 in astrocytes. J Immunol 181: 3167-3176.
42. Renault-Mihara F, Okada S, Shibata S, Nakamura M, Toyama Y, Okano H. 2008. Spinal cord injury: Emerging beneficial role of reactive astrocytes' migration. Int J Biochem Cell Biol 40: 1649-1653.
43. Rhoades KL, Golub SH, Economou JS. 1992. The regulation of the human tumor necrosis factor alpha promoter region in macrophage, T cell, and B cell lines. J Biol Chem 267: 22102-22107.
44. Ruggiero T, Trabucchi M, Ponassi M, Corte G, Chen C-Y, al-Haj L, Khabar K, Briata P, Gherzi R. 2007. Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling. BMC Mol Biol 8: 28.
45. Sarafi MN, Garcia-Zepeda EA, MacLean JA, Charo IF, Luster AD. 1997. Murine monocyte chemoattractant protein (MCP)-5: A novel CC chemokine that is a structural and functional homologue of human MCP-1. J Exp Med 185: 99-109.
46. Schuler GD, Cole MD. 1988. GM-CSF and oncogene mRNA stabilities are independently regulated in trans in a mouse monocytic tumor. Cell 55: 1115-1122.
47. Sofroniew MV, Vinters HV. 2010. Astrocytes: Biology and pathology. Acta Neuropathol 119: 7-35.
48. Sriram K, O'Callaghan JP. 2007. Divergent roles for tumor necrosis factor-alpha in the brain. J Neuroimmune Pharmacol 2: 140-153.
49. Tanabe S, Heesen M, Berman MA, Fischer MB, Yoshizawa I, Luo Y, Dorf ME. 1997. Murine astrocytes express a functional chemokine receptor. J Neurosci 17: 6522-6528.
50. Tebo J, Der S, Frevel M, Khabar KSA, Williams BRG, Hamilton TA. 2003. Heterogeneity in control of mRNA stability by AU-rich elements. J Biol Chem 278: 12085-12093.
51. Tezel G, Hernandez MR, Wax MB. 2001. In vitro evaluation of reactive astrocyte migration, a component of tissue remodeling in glaucomatous optic nerve head. Glia 34: 178-189.
52. Whitney NP, Eidem TM, Peng H, Huang Y, Zheng JC. 2009. Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders. J Neurochem 108: 1343-1359.
53. Williams A, Piaton G, Lubetzki C. 2007. Astrocytes-Friends or foes in multiple sclerosis? Glia 55: 1300-1312.
54. Winzen R, Thakur BK, Dittrich-Breiholz O, Shah M, Redich N, Dhamija S, Kracht M, Holtmann H. 2007. Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets. Mol Cell Biol 27: 8388-8400.
55. Zhang X, Chen H-M, Jaramillo E, Wang L, D'Mello SR. 2008. Histone deacetylase-related protein inhibits AES-mediated neuronal cell death by direct interaction. J Neurosci Res 86: 2423-2431.