TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases

Journal of Biological Chemistry

Volumn 284, Issue 33, 2009, Pages 22059-22066

  Iguchi, Yohei ^a   Katsuno, Masahisa ^a,b   Niwa, Jun Ichi ^c   Yamada, Shin Ichi ^a   Sone, Jun ^a   Waza, Masahiro ^a   Adachi, Hiroaki ^a   Tanaka, Fumiaki ^a   Nagata, Koh Ichi ^d   Arimura, Nariko ^a   Watanabe, Takashi ^b,e   Kaibuchi, Kozo ^e   Sobue, Gen ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

^c AICHI MEDICAL UNIVERSITY   (Japan)

^d INSTITUTE FOR DEVELOPMENTAL RESEARCH   (Japan)

^e TAMAGAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYOTROPHIC LATERAL SCLEROSIS; CELL VIABILITY; CELLULAR DAMAGE; DNA-BINDING PROTEIN; GERANYLGERANYLATION; GLIAL CELLS; GTPASES; INTRACELLULAR LOCALIZATION; MEMBRANE LOCALIZATION; NEURITE OUTGROWTH; NEURODEGENERATION; NEURONAL CELL; NUCLEAR PROTEINS; OVER-EXPRESSION; PHARMACOLOGICAL INHIBITION; RHO FAMILY; RHO FAMILY GTPASES; UBIQUITIN;

CELL DEATH; NUCLEIC ACIDS; PROTEINS;

CELL MEMBRANES;

GERANYLGERANYL PYROPHOSPHATE; GUANOSINE TRIPHOSPHATASE; PROTEIN CDC42; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TAR DNA BINDING PROTEIN;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL MEMBRANE; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE EXPRESSION; NERVE CELL NECROSIS; NERVE FIBER GROWTH; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REGULATORY MECHANISM;

ANIMALS; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; MICE; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; NEURONS; NEUROPEPTIDES; RAC GTP-BINDING PROTEINS; RHO GTP-BINDING PROTEINS; RNA, SMALL INTERFERING;

EID: 69249092183     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.012195     Document Type: Article

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