메뉴 건너뛰기




Volumn 9, Issue 11, 2014, Pages

A blueberry-enriched diet improves renal function and reduces oxidative stress in metabolic syndrome animals: Potential mechanism of TLR4-MAPK signaling pathway

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CYTOKINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

EID: 84910626509     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0111976     Document Type: Article
Times cited : (45)

References (61)
  • 1
    • 84865627930 scopus 로고    scopus 로고
    • Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United states, 2003-2006
    • Ervin RB (2009) Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United States, 2003-2006. Natl Health Stat Report: 1-7.
    • (2009) Natl Health Stat Report , pp. 1-7
    • Ervin, R.B.1
  • 2
    • 84875831501 scopus 로고    scopus 로고
    • Understanding the metabolic syndrome: A modeling perspective
    • Khoo MC, Oliveira FM, Cheng L (2013) Understanding the metabolic syndrome: a modeling perspective. IEEE Rev Biomed Eng 6: 143-155.
    • (2013) IEEE Rev Biomed Eng , vol.6 , pp. 143-155
    • Khoo, M.C.1    Oliveira, F.M.2    Cheng, L.3
  • 3
    • 60549116172 scopus 로고    scopus 로고
    • Chronic NF-{kappa}B blockade reduces cytosolic and mitochondrial oxidative stress and attenuates renal injury and hypertension in SHR
    • Elks CM, Mariappan N, Haque M., Guggilam A, Majid DS, et al. (2009) Chronic NF-{kappa}B blockade reduces cytosolic and mitochondrial oxidative stress and attenuates renal injury and hypertension in SHR. Am J Physiol Renal Physiol 296: F298-305.
    • (2009) Am J Physiol Renal Physiol , vol.296 , pp. F298-305
    • Elks, C.M.1    Mariappan, N.2    Haque, M.3    Guggilam, A.4    Majid, D.S.5
  • 5
    • 80052836184 scopus 로고    scopus 로고
    • A blueberry-enriched diet attenuates nephropathy in a rat model of hypertension via reduction in oxidative stress
    • Elks CM, Reed SD, Mariappan N, Shukitt-Hale B, Joseph J.A., et al. (2011) A blueberry-enriched diet attenuates nephropathy in a rat model of hypertension via reduction in oxidative stress. PLoS One 6: e24028.
    • (2011) PLoS One , vol.6
    • Elks, C.M.1    Reed, S.D.2    Mariappan, N.3    Shukitt-Hale, B.4    Joseph, J.A.5
  • 6
    • 84898741420 scopus 로고    scopus 로고
    • Role of TLR4 in lipopolysaccharide-induced acute kidney injury: Protection by blueberry
    • Nair AR, Masson GS, Ebenezer P.J., Del Piero F, Francis J (2014) Role of TLR4 in lipopolysaccharide-induced acute kidney injury: Protection by blueberry. Free Radic Biol Med 71C: 16-25.
    • (2014) Free Radic Biol Med , vol.71 C , pp. 16-25
    • Nair, A.R.1    Masson, G.S.2    Ebenezer, P.J.3    Del Piero, F.4    Francis, J.5
  • 7
    • 33947328104 scopus 로고    scopus 로고
    • Correlation between cardiac oxidative stress and myocardial pathology due to acute and chronic norepinephrine administration in rats
    • Neri M, Cerretani D, Fiaschi A.I., Laghi PF, Lazzerini PE, et al. (2007) Correlation between cardiac oxidative stress and myocardial pathology due to acute and chronic norepinephrine administration in rats. J Cell Mol Med 11: 156-170.
    • (2007) J Cell Mol Med , vol.11 , pp. 156-170
    • Neri, M.1    Cerretani, D.2    Fiaschi, A.I.3    Laghi, P.F.4    Lazzerini, P.E.5
  • 8
    • 36148948616 scopus 로고    scopus 로고
    • TNF-alpha-induced mitochondrial oxidative stress and cardiac dysfunction: Restoration by superoxide dismutase mimetic tempol
    • Mariappan N, Soorappan RN, Haque M, Sriramula S., Francis J (2007) TNF-alpha-induced mitochondrial oxidative stress and cardiac dysfunction: restoration by superoxide dismutase mimetic Tempol. Am J Physiol Heart Circ Physiol 293: H2726-2737.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293 , pp. H2726-2737
    • Mariappan, N.1    Soorappan, R.N.2    Haque, M.3    Sriramula, S.4    Francis, J.5
  • 9
    • 0034634281 scopus 로고    scopus 로고
    • Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress
    • Cai H, Harrison DG (2000) Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87: 840-844.
    • (2000) Circ Res , vol.87 , pp. 840-844
    • Cai, H.1    Harrison, D.G.2
  • 10
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the drosophila toll protein signals activation of adaptive immunity
    • Medzhitov R, Preston-Hurlburt P, Janeway CA Jr (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388: 394-397.
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway, C.A.3
  • 11
    • 0032133278 scopus 로고    scopus 로고
    • MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
    • Medzhitov R, Preston-Hurlburt P, Kopp E., Stadlen A, Chen C, et al. (1998) MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell 2: 253-258.
    • (1998) Mol Cell , vol.2 , pp. 253-258
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Kopp, E.3    Stadlen, A.4    Chen, C.5
  • 12
    • 0032526861 scopus 로고    scopus 로고
    • The human toll signaling pathway: Divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)
    • Muzio M, Natoli G, Saccani S., Levrero M, Mantovani A (1998) The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J Exp Med 187: 2097-2101.
    • (1998) J Exp Med , vol.187 , pp. 2097-2101
    • Muzio, M.1    Natoli, G.2    Saccani, S.3    Levrero, M.4    Mantovani, A.5
  • 13
    • 0035910010 scopus 로고    scopus 로고
    • Toll-like receptor-4 is expressed by macrophages in murine and human lipid-rich atherosclerotic plaques And upregulated by oxidized LDL
    • Xu XH, Shah PK, Faure E, Equils O., Thomas L, et al. (2001) Toll-like receptor-4 is expressed by macrophages in murine and human lipid-rich atherosclerotic plaques and upregulated by oxidized LDL. Circulation 104: 3103-3108.
    • (2001) Circulation , vol.104 , pp. 3103-3108
    • Xu, X.H.1    Shah, P.K.2    Faure, E.3    Equils, O.4    Thomas, L.5
  • 14
    • 84878310934 scopus 로고    scopus 로고
    • Increased tolllike receptor (TLR) mRNA expression in monocytes is a feature of metabolic syndrome in adolescents
    • Hardy OT, Kim A, Ciccarelli C., Hayman LL, Wiecha J (2013) Increased Tolllike receptor (TLR) mRNA expression in monocytes is a feature of metabolic syndrome in adolescents. Pediatr Obes 8: e19-23.
    • (2013) Pediatr Obes , vol.8 , pp. e19-23
    • Hardy, O.T.1    Kim, A.2    Ciccarelli, C.3    Hayman, L.L.4    Wiecha, J.5
  • 15
    • 84873544721 scopus 로고    scopus 로고
    • A critical role for MAPK signalling pathways in the transcriptional regulation of toll like receptors
    • Peroval MY, Boyd AC, Young J.R., Smith al (2013) A critical role for MAPK signalling pathways in the transcriptional regulation of toll like receptors. PLoS One 8: e51243.
    • (2013) PLoS One , vol.8
    • Peroval, M.Y.1    Boyd, A.C.2    Young, J.R.3    Smith, A.L.4
  • 16
    • 33846642114 scopus 로고    scopus 로고
    • The role of MAPK in kupffer cell toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhage
    • Thobe BM, Frink M, Hildebrand F., Schwacha MG, Hubbard WJ, et al. (2007) The role of MAPK in Kupffer cell toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhage. J Cell Physiol 210: 667-675.
    • (2007) J Cell Physiol , vol.210 , pp. 667-675
    • Thobe, B.M.1    Frink, M.2    Hildebrand, F.3    Schwacha, M.G.4    Hubbard, W.J.5
  • 17
    • 70349639668 scopus 로고    scopus 로고
    • Lipopolysaccharide directly alters renal tubule transport through distinct TLR4-dependent pathways in basolateral and apical membranes
    • Good DW, George T, Watts BA 3rd (2009) Lipopolysaccharide directly alters renal tubule transport through distinct TLR4-dependent pathways in basolateral and apical membranes. Am J Physiol Renal Physiol 297: F866-874.
    • (2009) Am J Physiol Renal Physiol , vol.297 , pp. F866-874
    • Good, D.W.1    George, T.2    Watts, B.A.3
  • 18
    • 78649730402 scopus 로고    scopus 로고
    • DPP-4 (CD26) inhibitor alogliptin inhibits TLR4-mediated ERK activation and ERK-dependent MMP-1 expression by U937 histiocytes
    • Ta NN, Li Y, Schuyler C.A., Lopes-Virella MF, Huang Y (2010) DPP-4 (CD26) inhibitor alogliptin inhibits TLR4-mediated ERK activation and ERK-dependent MMP-1 expression by U937 histiocytes. Atherosclerosis 213: 429-435.
    • (2010) Atherosclerosis , vol.213 , pp. 429-435
    • Ta, N.N.1    Li, Y.2    Schuyler, C.A.3    Lopes-Virella, M.F.4    Huang, Y.5
  • 19
    • 79551575483 scopus 로고    scopus 로고
    • Diabetic downregulation of nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo
    • Tan Y, Ichikawa T, Li J., Si Q, Yang H, et al. (2011) Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo. Diabetes 60: 625-633.
    • (2011) Diabetes , vol.60 , pp. 625-633
    • Tan, Y.1    Ichikawa, T.2    Li, J.3    Si, Q.4    Yang, H.5
  • 20
    • 1342346791 scopus 로고    scopus 로고
    • Effects of salt rich diet in the obese Zucker rats: Studies on renal function during isotonic volume expansion
    • Pamidimukkala J, Jandhyala BS (2004) Effects of salt rich diet in the obese Zucker rats: studies on renal function during isotonic volume expansion. Clin Exp Hypertens 26: 55-67.
    • (2004) Clin Exp Hypertens , vol.26 , pp. 55-67
    • Pamidimukkala, J.1    Jandhyala, B.S.2
  • 21
    • 63449140516 scopus 로고    scopus 로고
    • Protective effects of antioxidant-fortified diet on renal function and metabolic profile in obese Zucker rat
    • Slyvka Y, Inman SR, Malgor R, Jackson E.J., Yee J., et al. (2009) Protective effects of antioxidant-fortified diet on renal function and metabolic profile in obese Zucker rat. Endocrine 35: 89-100.
    • (2009) Endocrine , vol.35 , pp. 89-100
    • Slyvka, Y.1    Inman, S.R.2    Malgor, R.3    Jackson, E.J.4    Yee, J.5
  • 22
    • 84874115404 scopus 로고    scopus 로고
    • Obesity increases cerebrocortical reactive oxygen species and impairs brain function
    • Freeman LR, Zhang L, Nair A., Dasuri K, Francis J, et al. (2013) Obesity increases cerebrocortical reactive oxygen species and impairs brain function. Free Radic Biol Med 56: 226-233.
    • (2013) Free Radic Biol Med , vol.56 , pp. 226-233
    • Freeman, L.R.1    Zhang, L.2    Nair, A.3    Dasuri, K.4    Francis, J.5
  • 23
    • 84885132242 scopus 로고    scopus 로고
    • Inflammation and oxidative stress are elevated in the brain, blood, and adrenal glands during the progression of post-traumatic stress disorder in a predator exposure animal model
    • Wilson CB, McLaughlin LD, Nair A, Ebenezer P.J., Dange R., et al. (2013) Inflammation and oxidative stress are elevated in the brain, blood, and adrenal glands during the progression of post-traumatic stress disorder in a predator exposure animal model. PLoS One 8: e76146.
    • (2013) PLoS One , vol.8
    • Wilson, C.B.1    McLaughlin, L.D.2    Nair, A.3    Ebenezer, P.J.4    Dange, R.5
  • 24
    • 84898985836 scopus 로고    scopus 로고
    • Valproic acid effects in the hippocampus and prefrontal cortex in an animal model of post-traumatic stress disorder
    • Wilson CB, McLaughlin LD, Ebenezer P.J., Nair AR, Francis J (2014) Valproic acid effects in the hippocampus and prefrontal cortex in an animal model of post-traumatic stress disorder. Behav Brain Res.
    • (2014) Behav Brain Res
    • Wilson, C.B.1    McLaughlin, L.D.2    Ebenezer, P.J.3    Nair, A.R.4    Francis, J.5
  • 25
    • 84875016368 scopus 로고    scopus 로고
    • (Pro)renin receptor mediates both angiotensin II-dependent and -independent oxidative stress in neuronal cells
    • Peng H, Li W, Seth D.M., Nair AR, Francis J, et al. (2013) (Pro)renin receptor mediates both angiotensin II-dependent and -independent oxidative stress in neuronal cells. PLoS One 8: e58339.
    • (2013) PLoS One , vol.8
    • Peng, H.1    Li, W.2    Seth, D.M.3    Nair, A.R.4    Francis, J.5
  • 26
    • 16644385307 scopus 로고    scopus 로고
    • The relationship between hyperinsulinemia, hypertension and progressive renal disease
    • El-Atat FA, Stas SN, McFarlane S.I., Sowers JR (2004) The relationship between hyperinsulinemia, hypertension and progressive renal disease. J Am Soc Nephrol 15: 2816-2827.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 2816-2827
    • El-Atat, F.A.1    Stas, S.N.2    McFarlane, S.I.3    Sowers, J.R.4
  • 27
    • 34748828509 scopus 로고    scopus 로고
    • Obesity and obesity-initiated metabolic syndrome: Mechanistic links to chronic kidney disease
    • Wahba IM, Mak RH (2007) Obesity and obesity-initiated metabolic syndrome: mechanistic links to chronic kidney disease. Clin J Am Soc Nephrol 2: 550-562.
    • (2007) Clin J Am Soc Nephrol , vol.2 , pp. 550-562
    • Wahba, I.M.1    Mak, R.H.2
  • 28
    • 84878446398 scopus 로고    scopus 로고
    • Renal protective effects of toll-like receptor 4 signaling blockade in type 2 diabetic mice
    • Cha JJ, Hyun YY, Lee M.H., Kim JE, Nam DH, et al. (2013) Renal protective effects of toll-like receptor 4 signaling blockade in type 2 diabetic mice. Endocrinology 154: 2144-2155.
    • (2013) Endocrinology , vol.154 , pp. 2144-2155
    • Cha, J.J.1    Hyun, Y.Y.2    Lee, M.H.3    Kim, J.E.4    Nam, D.H.5
  • 30
    • 84859348886 scopus 로고    scopus 로고
    • Metabolic syndrome, insulin resistance and kidney function in non-diabetic individuals
    • Johns BR, Pao AC, Kim SH (2012) Metabolic syndrome, insulin resistance and kidney function in non-diabetic individuals. Nephrol Dial Transplant 27: 1410-1415.
    • (2012) Nephrol Dial Transplant , vol.27 , pp. 1410-1415
    • Johns, B.R.1    Pao, A.C.2    Kim, S.H.3
  • 31
    • 77952957963 scopus 로고    scopus 로고
    • Role of renal perfusion pressure versus angiotensin II on renal oxidative stress in angiotensin II-induced hypertensive rats
    • Polichnowski AJ, Jin C, Yang C., Cowley AW, Jr. (2010) Role of renal perfusion pressure versus angiotensin II on renal oxidative stress in angiotensin II-induced hypertensive rats. Hypertension 55: 1425-1430.
    • (2010) Hypertension , vol.55 , pp. 1425-1430
    • Polichnowski, A.J.1    Jin, C.2    Yang, C.3    Cowley, A.W.4
  • 32
    • 0033104754 scopus 로고    scopus 로고
    • Angiotensin II plays a pathogenic role in immune-mediated renal injury in mice
    • Hisada Y, Sugaya T, Yamanouchi M., Uchida H, Fujimura H, et al. (1999) Angiotensin II plays a pathogenic role in immune-mediated renal injury in mice. J Clin Invest 103: 627-635.
    • (1999) J Clin Invest , vol.103 , pp. 627-635
    • Hisada, Y.1    Sugaya, T.2    Yamanouchi, M.3    Uchida, H.4    Fujimura, H.5
  • 33
    • 84903177300 scopus 로고    scopus 로고
    • Role of vascular oxidative stress in obesity and metabolic syndrome
    • Youn JY, Siu KL, Lob H, Itani H., Harrison DG, et al. (2014) Role of Vascular Oxidative Stress in Obesity and Metabolic Syndrome. Diabetes.
    • (2014) Diabetes
    • Youn, J.Y.1    Siu, K.L.2    Lob, H.3    Itani, H.4    Harrison, D.G.5
  • 35
    • 33645452371 scopus 로고    scopus 로고
    • Chronic hypoxia and tubulointerstitial injury: A final common pathway to end-stage renal failure
    • Nangaku M (2006) Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. J Am Soc Nephrol 17: 17-25.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 17-25
    • Nangaku, M.1
  • 36
    • 84884593246 scopus 로고    scopus 로고
    • The pathogenesis of acute kidney injury and the toxic triangle of oxygen, reactive oxygen species and nitric oxide
    • Aksu U, Demirci C, Ince C (2011) The pathogenesis of acute kidney injury and the toxic triangle of oxygen, reactive oxygen species and nitric oxide. Contrib Nephrol 174: 119-128.
    • (2011) Contrib Nephrol , vol.174 , pp. 119-128
    • Aksu, U.1    Demirci, C.2    Ince, C.3
  • 37
    • 0031028998 scopus 로고    scopus 로고
    • Clinical evidence of peroxynitrite formation in chronic renal failure patients with septic shock
    • Fukuyama N, Takebayashi Y, Hida M., Ishida H, Ichimori K, et al. (1997) Clinical evidence of peroxynitrite formation in chronic renal failure patients with septic shock. Free Radic Biol Med 22: 771-774.
    • (1997) Free Radic Biol Med , vol.22 , pp. 771-774
    • Fukuyama, N.1    Takebayashi, Y.2    Hida, M.3    Ishida, H.4    Ichimori, K.5
  • 38
    • 84887194508 scopus 로고    scopus 로고
    • Metabolic syndrome-induced tubulointerstitial injury: Role of oxidative stress and preventive effects of acetaminophen
    • Wang C, Blough ER, Arvapalli R, Dai X., Paturi S, et al. (2013) Metabolic syndrome-induced tubulointerstitial injury: role of oxidative stress and preventive effects of acetaminophen. Free Radic Biol Med 65: 1417-1426.
    • (2013) Free Radic Biol Med , vol.65 , pp. 1417-1426
    • Wang, C.1    Blough, E.R.2    Arvapalli, R.3    Dai, X.4    Paturi, S.5
  • 39
    • 3242813758 scopus 로고    scopus 로고
    • Differential calcium regulation by hydrogen peroxide and superoxide in vascular smooth muscle cells from spontaneously hypertensive rats
    • Tabet F, Savoia C, Schiffrin E.L., Touyz RM (2004) Differential calcium regulation by hydrogen peroxide and superoxide in vascular smooth muscle cells from spontaneously hypertensive rats. J Cardiovasc Pharmacol 44: 200-208.
    • (2004) J Cardiovasc Pharmacol , vol.44 , pp. 200-208
    • Tabet, F.1    Savoia, C.2    Schiffrin, E.L.3    Touyz, R.M.4
  • 40
    • 84884222073 scopus 로고    scopus 로고
    • Thromboxane-induced renal vasoconstriction is mediated by the ADP-ribosyl cyclase CD38 and superoxide anion
    • Moss NG, Vogel PA, Kopple T.E., Arendshorst WJ (2013) Thromboxane-induced renal vasoconstriction is mediated by the ADP-ribosyl cyclase CD38 and superoxide anion. Am J Physiol Renal Physiol 305: F830-838.
    • (2013) Am J Physiol Renal Physiol , vol.305 , pp. F830-838
    • Moss, N.G.1    Vogel, P.A.2    Kopple, T.E.3    Arendshorst, W.J.4
  • 42
    • 0742266631 scopus 로고    scopus 로고
    • The metabolic syndrome and chronic kidney disease in U.S. Adults
    • Chen J, Muntner P, Hamm L.L., Jones DW, Batuman V, et al. (2004) The metabolic syndrome and chronic kidney disease in U.S. adults. Ann Intern Med 140: 167-174.
    • (2004) Ann Intern Med , vol.140 , pp. 167-174
    • Chen, J.1    Muntner, P.2    Hamm, L.L.3    Jones, D.W.4    Batuman, V.5
  • 43
    • 0035047374 scopus 로고    scopus 로고
    • Proteinuria and focal segmental glomerulosclerosis in severely obese adolescents
    • Adelman RD, Restaino IG, Alon U.S., Blowey DL (2001) Proteinuria and focal segmental glomerulosclerosis in severely obese adolescents. J Pediatr 138: 481-485.
    • (2001) J Pediatr , vol.138 , pp. 481-485
    • Adelman, R.D.1    Restaino, I.G.2    Alon, U.S.3    Blowey, D.L.4
  • 44
    • 84897030035 scopus 로고    scopus 로고
    • Drug-induced renal fanconi syndrome
    • Hall AM, Bass P, Unwin RJ (2014) Drug-induced renal Fanconi syndrome. QJM 107: 261-269.
    • (2014) QJM , vol.107 , pp. 261-269
    • Hall, A.M.1    Bass, P.2    Unwin, R.J.3
  • 45
    • 2142646426 scopus 로고    scopus 로고
    • TGF-beta signaling and the fibrotic response
    • Leask A, Abraham DJ (2004) TGF-beta signaling and the fibrotic response. Faseb j 18: 816-827.
    • (2004) Faseb J , vol.18 , pp. 816-827
    • Leask, A.1    Abraham, D.J.2
  • 46
    • 79958767773 scopus 로고    scopus 로고
    • Renal TLR4 mRNA expression correlates with inflammatory marker MCP-1 and profibrotic molecule TGF-beta(1) in patients with chronic kidney disease
    • Lepenies J, Eardley KS, Kienitz T, Hewison M., Ihl T, et al. (2011) Renal TLR4 mRNA expression correlates with inflammatory marker MCP-1 and profibrotic molecule TGF-beta(1) in patients with chronic kidney disease. Nephron Clin Pract 119: c97-c104.
    • (2011) Nephron Clin Pract , vol.119 , pp. c97-c104
    • Lepenies, J.1    Eardley, K.S.2    Kienitz, T.3    Hewison, M.4    Ihl, T.5
  • 47
    • 0032923362 scopus 로고    scopus 로고
    • Melatonin and taurine reduce early glomerulopathy in diabetic rats
    • Ha H, Yu MR, Kim KH (1999) Melatonin and taurine reduce early glomerulopathy in diabetic rats. Free Radic Biol Med 26: 944-950.
    • (1999) Free Radic Biol Med , vol.26 , pp. 944-950
    • Ha, H.1    Yu, M.R.2    Kim, K.H.3
  • 48
    • 84905163411 scopus 로고    scopus 로고
    • Toll-like receptor, lipotoxicity and chronic inflammation: The pathological link between obesity and cardiometabolic disease
    • Eguchi K, Manabe I (2014) Toll-Like Receptor, Lipotoxicity and Chronic inflammation: The Pathological Link Between Obesity and Cardiometabolic Disease. J Atheroscler Thromb.
    • (2014) J Atheroscler Thromb
    • Eguchi, K.1    Manabe, I.2
  • 49
    • 84892182388 scopus 로고    scopus 로고
    • Metformin decreases high-fat diet-induced renal injury by regulating the expression of adipokines and the renal AMP-activated protein kinase/acetyl-coa carboxylase pathway in mice
    • Kim D, Lee JE, Jung Y.J., Lee AS, Lee S, et al. (2013) Metformin decreases high-fat diet-induced renal injury by regulating the expression of adipokines and the renal AMP-activated protein kinase/acetyl-CoA carboxylase pathway in mice. Int J Mol Med 32: 1293-1302.
    • (2013) Int J Mol Med , vol.32 , pp. 1293-1302
    • Kim, D.1    Lee, J.E.2    Jung, Y.J.3    Lee, A.S.4    Lee, S.5
  • 50
    • 79952182053 scopus 로고    scopus 로고
    • Toll-like receptor expression in monocytes in patients with chronic kidney disease and haemodialysis: Relation with inflammation
    • Koc M, Toprak A, Arikan H., Odabasi Z, Elbir Y, et al. (2011) Toll-like receptor expression in monocytes in patients with chronic kidney disease and haemodialysis: relation with inflammation. Nephrol Dial Transplant 26: 955-963.
    • (2011) Nephrol Dial Transplant , vol.26 , pp. 955-963
    • Koc, M.1    Toprak, A.2    Arikan, H.3    Odabasi, Z.4    Elbir, Y.5
  • 51
    • 78751494753 scopus 로고    scopus 로고
    • C-reactive protein impairs hepatic insulin sensitivity and insulin signaling in rats: Role of mitogen-activated protein kinases
    • Xi L, Xiao C, Bandsma R.H., Naples M., Adeli K, et al. (2011) C-reactive protein impairs hepatic insulin sensitivity and insulin signaling in rats: role of mitogen-activated protein kinases. Hepatology 53: 127-135.
    • (2011) Hepatology , vol.53 , pp. 127-135
    • Xi, L.1    Xiao, C.2    Bandsma, R.H.3    Naples, M.4    Adeli, K.5
  • 52
    • 84891670849 scopus 로고    scopus 로고
    • Spironolactone prevents dietary-induced metabolic syndrome by inhibiting PI3-K/Akt and p38MAPK signaling pathways
    • Long HD, Lin YE, Liu M.J., Liang LY, Zeng ZH (2013) Spironolactone prevents dietary-induced metabolic syndrome by inhibiting PI3-K/Akt and p38MAPK signaling pathways. J Endocrinol Invest 36: 923-930.
    • (2013) J Endocrinol Invest , vol.36 , pp. 923-930
    • Long, H.D.1    Lin, Y.E.2    Liu, M.J.3    Liang, L.Y.4    Zeng, Z.H.5
  • 53
    • 33745236658 scopus 로고    scopus 로고
    • Oxidative signaling in renal epithelium: Critical role of cytosolic phospholipase A2 and p38(SAPK)
    • Cui XL, Ding Y, Alexander L.D., Bao C., Al-Khalili OK, et al. (2006) Oxidative signaling in renal epithelium: Critical role of cytosolic phospholipase A2 and p38(SAPK). Free Radic Biol Med 41: 213-221.
    • (2006) Free Radic Biol Med , vol.41 , pp. 213-221
    • Cui, X.L.1    Ding, Y.2    Alexander, L.D.3    Bao, C.4    Al-Khalili, O.K.5
  • 54
    • 84877662957 scopus 로고    scopus 로고
    • Oxidative stress induces inactivation of protein phosphatase 2A, promoting proinflammatory NF-kappaB in aged rat kidney
    • Jin Jung K, Hyun Kim D, Kyeong Lee E, Woo Song C, Pal Yu B, et al. (2013) Oxidative stress induces inactivation of protein phosphatase 2A, promoting proinflammatory NF-kappaB in aged rat kidney. Free Radic Biol Med 61C: 206-217.
    • (2013) Free Radic Biol Med , vol.61 C , pp. 206-217
    • Jin Jung, K.1    Hyun Kim, D.2    Kyeong Lee, E.3    Woo Song, C.4    Pal Yu., B.5
  • 55
    • 66449088641 scopus 로고    scopus 로고
    • Pathogen recognition and inflammatory signaling in innate immune defenses
    • Mogensen TH (2009) Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses. Clinical Microbiology Reviews 22: 240-273.
    • (2009) Clinical Microbiology Reviews , vol.22 , pp. 240-273
    • Mogensen, T.H.1
  • 56
    • 84862278910 scopus 로고    scopus 로고
    • Aldosterone, oxidative stress, and NF-kappaB activation in hypertension-related cardiovascular and renal diseases
    • Queisser N, Schupp N (2012) Aldosterone, oxidative stress, and NF-kappaB activation in hypertension-related cardiovascular and renal diseases. Free Radic Biol Med 53: 314-327.
    • (2012) Free Radic Biol Med , vol.53 , pp. 314-327
    • Queisser, N.1    Schupp, N.2
  • 57
    • 84868210978 scopus 로고    scopus 로고
    • Nrf2-keap1 system versus NF-kappaB: The good and the evil in chronic kidney disease
    • Pedruzzi LM, Stockler-Pinto MB, Leite M Jr, Mafra D (2012) Nrf2-keap1? system versus NF-kappaB: the good and the evil in chronic kidney disease? Biochimie 94: 2461-2466.
    • (2012) Biochimie , vol.94 , pp. 2461-2466
    • Pedruzzi, L.M.1    Stockler-Pinto, M.B.2    Leite, M.3    Mafra, D.4
  • 58
    • 84903148579 scopus 로고    scopus 로고
    • Osthole improves an accelerated focal segmental glomerulosclerosis model in early stage by activating nrf2 antioxidant pathway and subsequent inhibition of NF-kappaB-mediated COX-2 expression and apoptosis
    • Yang SM, Chan YL, Hua K.F., Chang JM, Chen HL, et al. (2014) Osthole improves an accelerated focal segmental glomerulosclerosis model in early stage by activating Nrf2 antioxidant pathway and subsequent inhibition of NF-kappaB-mediated COX-2 expression and apoptosis. Free Radic Biol Med.
    • (2014) Free Radic Biol Med
    • Yang, S.M.1    Chan, Y.L.2    Hua, K.F.3    Chang, J.M.4    Chen, H.L.5
  • 59
    • 0036667558 scopus 로고    scopus 로고
    • Renal damage mediated by oxidative stress: A hypothesis of protective effects of red wine
    • Rodrigo R, Rivera G (2002) Renal damage mediated by oxidative stress: a hypothesis of protective effects of red wine. Free Radic Biol Med 33: 409-422.
    • (2002) Free Radic Biol Med , vol.33 , pp. 409-422
    • Rodrigo, R.1    Rivera, G.2
  • 60
    • 79952271561 scopus 로고    scopus 로고
    • Nrf2 and NF-kappaB and their concerted modulation in cancer pathogenesis and progression
    • Bellezza I, Mierla al, Minelli A (2010) Nrf2 and NF-kappaB and Their Concerted Modulation in Cancer Pathogenesis and Progression. Cancers (Basel) 2: 483-497.
    • (2010) Cancers (Basel) , vol.2 , pp. 483-497
    • Bellezza, I.1    Mierla, A.L.2    Minelli, A.3
  • 61
    • 12444257799 scopus 로고    scopus 로고
    • Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of nrf2 in response to electrophiles
    • Itoh K, Wakabayashi N, Katoh Y., Ishii T, O'Connor T, et al. (2003) Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells 8: 379-391.
    • (2003) Genes Cells , vol.8 , pp. 379-391
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    O'Connor, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.