Obesity-induced tissue free radical generation: An in vivo immuno-spin trapping study

Free Radical Biology and Medicine

Volumn 52, Issue 11-12, 2012, Pages 2312-2319

  Khoo, Nicholas K H ^a   Cantu Medellin, Nadiezhda ^a   Devlin, Jason E ^a   St Croix, Claudette M ^a   Watkins, Simon C ^a   Fleming, Alexander M ^a   Champion, Hunter C ^a   Mason, Ronald P ^b   Freeman, Bruce A ^a   Kelley, Eric E ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Free radicals; Immuno spin trapping; Inflammation; Obesity; Oxidative stress

Indexed keywords

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; FREE RADICAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC INFLAMMATION; CONTROLLED STUDY; HEART RIGHT VENTRICLE FAILURE; IMMUNO SPIN TRAPPING; IMMUNOHISTOCHEMISTRY; KIDNEY; LIVER LEVEL; MACROMOLECULE; MALE; MOUSE; MUSCLE LEVEL; NONHUMAN; OBESITY; OXIDATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; SKELETAL MUSCLE;

ANIMALS; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; FEASIBILITY STUDIES; FREE RADICALS; HUMANS; HYPERTENSION, PULMONARY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KIDNEY; LIVER; MICE; MONOCROTALINE; MUSCLE, SKELETAL; OBESITY; OXIDATION-REDUCTION; RATS; SPIN TRAPPING;

MUS; RATTUS;

EID: 84861709993     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.04.011     Document Type: Article

References (25)

1. A. Whaley-Connell, P.A. McCullough, and J.R. Sowers The role of oxidative stress in the metabolic syndrome Rev. Cardiovasc. Med. 12 2011 21 29
2. S. Furukawa, T. Fujita, M. Shimabukuro, M. Iwaki, Y. Yamada, Y. Nakajima, O. Nakayama, M. Makishima, M. Matsuda, and I. Shimomura Increased oxidative stress in obesity and its impact on metabolic syndrome J. Clin. Invest. 114 2004 1752 1761
3. J.F. Keaney Jr., M.G. Larson, R.S. Vasan, P.W. Wilson, I. Lipinska, D. Corey, J.M. Massaro, P. Sutherland, J.A. Vita, and E.J. Benjamin Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study Arterioscler. Thromb. Vasc. Biol. 23 2003 434 439
4. M.M. Tarpey, D.A. Wink, and M.B. Grisham Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerations Am. J. Physiol. Regul. Integr. Comp. Physiol 286 2004 R431 R444
5. R.P. Mason Using anti-5,5-dimethyl-1-pyrroline N-oxide (anti-DMPO) to detect protein radicals in time and space with immuno-spin trapping Free Radic. Biol. Med 36 2004 1214 1223
6. S. Chatterjee, M. Ehrenshaft, S. Bhattacharjee, L.J. Deterding, M.G. Bonini, J. Corbett, M.B. Kadiiska, K.B. Tomer, and R.P. Mason Immuno-spin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine oxidase and endothelial nitric oxide synthase in acute septic mice Free Radic. Biol. Med. 46 2009 454 461
7. C. Kojima, D.C. Ramirez, E.J. Tokar, S. Himeno, Z. Drobna, M. Styblo, R.P. Mason, and M.P. Waalkes Requirement of arsenic biomethylation for oxidative DNA damage J. Natl. Cancer Inst. 101 2009 1670 1681
8. A.G. Siraki, L.J. Deterding, M.G. Bonini, J. Jiang, M. Ehrenshaft, K.B. Tomer, and R.P. Mason Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis Chem. Res. Toxicol. 21 2008 1143 1153
9. K. Stadler, M.G. Bonini, S. Dallas, D. Duma, R.P. Mason, and M.B. Kadiiska Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis Am. J. Physiol. Endocrinol. Metab. 295 2008 E456 462
10. M. Narwaley, K. Michail, P. Arvadia, and A.G. Siraki Drug-induced protein free radical formation is attenuated by unsaturated fatty acids by scavenging drug-derived phenyl radical metabolites Chem. Res. Toxicol 24 2011 1031 1039
11. A.L. Zaiman, M. Podowski, S. Medicherla, K. Gordy, F. Xu, L. Zhen, L.A. Shimoda, E. Neptune, L. Higgins, A. Murphy, S. Chakravarty, A. Protter, P.B. Sehgal, H.C. Champion, and R.M. Tuder Role of the TGF-β/Alk5 signaling pathway in monocrotaline-induced pulmonary hypertension Am. J. Respir. Crit. Care Med. 177 2008 896 905
12. J. Zielonka, M. Zielonka, A. Sikora, J. Adamus, J. Joseph, M. Hardy, O. Ouari, B.P. Dranka, and B. Kalyanaraman Global profiling of reactive oxygen and nitrogen species in biological systems: high-throughput real-time analyses J. Biol. Chem. 287 2012 2984 2995
13. B. Kalyanaraman, V. Darley-Usmar, K.J. Davies, P.A. Dennery, H.J. Forman, M.B. Grisham, G.E. Mann, K. Moore, L.J. Roberts 2nd, and H. Ischiropoulos Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations Free Radic. Biol. Med. 52 2012 1 6
14. J. Zielonka, and B. Kalyanaraman Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: another inconvenient truth Free Radic. Biol. Med 48 2010 983 1001
15. C. Ruggiero, M. Ehrenshaft, E. Cleland, and K. Stadler High-fat diet induces an initial adaptation of mitochondrial bioenergetics in the kidney despite evident oxidative stress and mitochondrial ROS production Am. J. Physiol. Endocrinol. Metab 300 2011 E1047 1058
16. P. Cassina, A. Cassina, M. Pehar, R. Castellanos, M. Gandelman, A. de León, K.M. Robinson, R.P. Mason, J.S. Beckman, L. Barbeito, and R. Radi Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants J. Neurosci. 28 2008 4115 4122
17. A.G. Barbeito, H.J. Garringer, M.A. Baraibar, X. Gao, M. Arredondo, M.T. Núñez, M.A. Smith, B. Ghetti, and R. Vidal Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene J. Neurochem. 109 2009 1067 1078
18. A. Odermatt The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease Am. J. Physiol. Renal Physiol 301 2011 F919 931
19. S.A. Noeman, H.E. Hamooda, and A.A. Baalash Biochemical study of oxidative stress markers in the liver, kidney and heart of high fat diet induced obesity in rats Diabetol. Metab. Syndr 3 2011 17
20. Y. Tomino, S. Hagiwara, and T. Gohda AGE-RAGE interaction and oxidative stress in obesity-related renal dysfunction Kidney Int. 80 2011 133 135
21. N. Lefort, B. Glancy, B. Bowen, W.T. Willis, Z. Bailowitz, E.A. De Filippis, C. Brophy, C. Meyer, K. Hojlund, Z. Yi, and L.J. Mandarino Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle Diabetes 59 2010 2444 2452
22. C. Bonnard, A. Durand, S. Peyrol, E. Chanseaume, M.A. Chauvin, B. Morio, H. Vidal, and J. Rieusset Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice J. Clin. Invest. 118 2008 789 800
23. A.E. Schultze, and R.A. Roth Chronic pulmonary hypertension - the monocrotaline model and involvement of the hemostatic system J. Toxicol. Environ. Health B Crit. Rev. 1 1998 271 346
24. E.M. Redout, A. van der Toorn, M.J. Zuidwijk, C.W. van de Kolk, C.J. van Echteld, R.J. Musters, C. van Hardeveld, W.J. Paulus, and W.S. Simonides Antioxidant treatment attenuates pulmonary arterial hypertension-induced heart failure Am. J. Physiol. Heart Circ. Physiol 298 2010 H1038 1047
25. National Center for Health Statistics, NCHS Data Brief No. 56, March 2011. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention.