Hypoxia diminishes the detoxification of the environmental mutagen benzo[a]pyrene

Mutagenesis

Volumn 29, Issue 6, 2014, Pages 481-487

  Schults, Marten A ^a   Sanen, Kathleen ^a   Godschalk, Roger W ^a   Theys, Jan ^a   Van Schooten, Frederik J ^a   Chiu, Roland K ^a,b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BENZO[A]PYRENE; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; ENVIRONMENTAL MUTAGEN; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 2B7; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXYGEN; UNSPECIFIC MONOOXYGENASE; 7,8 DIHYDRO 7,8 DIHYDROXYBENZO[A]PYRENE; BENZO(A)PYRENE 7,8-DIHYDRODIOL; BENZO[A]PYRENE 7,8 DIHYDRODIOL 9,10 OXIDE; CULTURE MEDIUM; DNA ADDUCT; GLUCURONOSYLTRANSFERASE; MUTAGENIC AGENT; POLLUTANT; UDP-GLUCURONOSYLTRANSFERASE, UGT1A6; UGT2B7 PROTEIN, HUMAN;

ARTICLE; CELL METABOLISM; COMPARATIVE STUDY; DETOXIFICATION; DNA ADDUCT; DNA ISOLATION; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYPOXIA; HYPOXIC CELL; KINETICS; LUNG CARCINOMA; METABOLIC ACTIVATION; METABOLITE; MUTAGENICITY; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; CELL HYPOXIA; CHEMISTRY; CULTURE MEDIUM; DRUG EFFECTS; DRUG INACTIVATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; POLLUTANT; TIME; TOXICITY; TUMOR CELL LINE;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; BENZO(A)PYRENE; CELL HYPOXIA; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CULTURE MEDIA; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1B1; DIHYDROXYDIHYDROBENZOPYRENES; DNA ADDUCTS; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCURONOSYLTRANSFERASE; HUMANS; INACTIVATION, METABOLIC; KINETICS; MUTAGENS; OXYGEN; TIME FACTORS;

EID: 84910603288     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/geu034     Document Type: Article

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