메뉴 건너뛰기




Volumn 16, Issue 4, 2009, Pages 279-285

The pancreas in human type 1 diabetes: Providing new answers to age-old questions

Author keywords

Autoimmunity; Histology; Islets; Pancreas; Type 1 diabetes

Indexed keywords

INSULIN;

EID: 67651107348     PISSN: 1752296X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MED.0b013e32832e06ba     Document Type: Review
Times cited : (55)

References (32)
  • 1
    • 76549198972 scopus 로고
    • Pathologic anatomy of the pancreas in juvenile diabetes mellitus
    • Gepts W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 1965; 14:619-633.
    • (1965) Diabetes , vol.14 , pp. 619-633
    • Gepts, W.1
  • 2
    • 0022475906 scopus 로고
    • The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: A 25-year review of deaths in patients under 20 years of age in the United Kingdom
    • Foulis AK, Liddle CN, Farquharson MA, et al. The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia 1986; 29:267-274.
    • (1986) Diabetologia , vol.29 , pp. 267-274
    • Foulis, A.K.1    Liddle, C.N.2    Farquharson, M.A.3
  • 5
    • 0027298334 scopus 로고
    • A solid and papillary (solid-cystic) tumor of the pancreas occurring in a 36-year-old man: Report of a case
    • DOI 10.1007/BF00730634
    • Ohashi K, Nakajima Y, Hisanaga M, et al. A solid and papillary (solid-cystic) tumor of the pancreas occurring in a 36-year-old man: report of a case. Surg Today 1993; 23:551-555. (Pubitemid 23166592)
    • (1993) Surgery Today , vol.23 , Issue.6 , pp. 551-555
    • Ohashi, K.1    Nakajima, Y.2    Hisanaga, M.3    Nakano, H.4    Tsutsumi, M.5    Kondoh, S.6    Konishi, Y.7
  • 6
    • 33646428917 scopus 로고    scopus 로고
    • Initial results of screening of nondiabetic organ donors for expression of islet autoantibodies
    • Gianani R, Putnam A, Still T, et al. Initial results of screening of nondiabetic organ donors for expression of islet autoantibodies. J Clin Endocrinol Metab 2006; 91:1855-1861.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1855-1861
    • Gianani, R.1    Putnam, A.2    Still, T.3
  • 9
    • 0021252607 scopus 로고
    • The pancreas in recent-onset type 1 (insulin-dependent) diabetes mellitus: Insulin content of islets, insulitis and associated changes in the exocrine acinar tissue
    • Foulis AK, Stewart JA. The pancreas in recent-onset type 1 (insulin-dependent) diabetes mellitus: insulin content of islets, insulitis and associated changes in the exocrine acinar tissue. Diabetologia 1984; 26:456-461.
    • (1984) Diabetologia , vol.26 , pp. 456-461
    • Foulis, A.K.1    Stewart, J.A.2
  • 10
    • 45249113309 scopus 로고    scopus 로고
    • + T-cells and their interaction with other cells in damage to islet β-cells
    • DOI 10.1042/BST0360316
    • Wong FS, Siew LK, Wen L. CD8+ T-cells and their interaction with other cells in damage to islet beta-cells. Biochem Soc Trans 2008; 36:316-320. (Pubitemid 351839323)
    • (2008) Biochemical Society Transactions , vol.36 , Issue.3 , pp. 316-320
    • Wong, F.S.1    Siew, L.K.2    Wen, L.3
  • 11
    • 58149299735 scopus 로고    scopus 로고
    • Analysis of islet inflammation in human type 1 diabetes
    • Willcox A, Richardson SJ, Bone AJ, et al. Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol 2009; 155:173-181.
    • (2009) Clin Exp Immunol , vol.155 , pp. 173-181
    • Willcox, A.1    Richardson, S.J.2    Bone, A.J.3
  • 12
    • 67651124359 scopus 로고    scopus 로고
    • Insulitis in human type 1 diabetes
    • One of the more interesting 'forms' of diabetes to be recognized is that of so-called 'fulminate' disease and thus this work, through its histologic examination of pancreata from individuals with disease, is of particular merit
    • Hanafusa T, Imagawa A. Insulitis in human type 1 diabetes. Diabetes 2008; 57:2883-2888. One of the more interesting 'forms' of diabetes to be recognized is that of so-called 'fulminate' disease and thus this work, through its histologic examination of pancreata from individuals with disease, is of particular merit.
    • (2008) Diabetes , vol.57 , pp. 2883-2888
    • Hanafusa, T.1    Imagawa, A.2
  • 13
    • 34848851427 scopus 로고    scopus 로고
    • Modestly increased beta cell apoptosis but no increased beta cell replication in recent-onset type 1 diabetic patients who died of diabetic ketoacidosis
    • DOI 10.1007/s00125-007-0794-x
    • Butler AE, Galasso R, Meier JJ, et al. Modestly increased beta cell apoptosis but no increased beta cell replication in recent-onset type 1 diabetic patients who died of diabetic ketoacidosis. Diabetologia 2007; 50:2323-2331. (Pubitemid 47512399)
    • (2007) Diabetologia , vol.50 , Issue.11 , pp. 2323-2331
    • Butler, A.E.1    Galasso, R.2    Meier, J.J.3    Basu, R.4    Rizza, R.A.5    Butler, P.C.6
  • 14
    • 0024414513 scopus 로고
    • In type 1 diabetes, does a noncytopathic viral infection of insulin-secreting B-cells initiate the disease process leading to their autoimmune destruction?
    • Foulis AK. In type 1 diabetes, does a noncytopathic viral infection of insulin-secreting B-cells initiate the disease process leading to their autoimmune destruction? Diabet Med 1989; 6:666-674.
    • (1989) Diabet Med , vol.6 , pp. 666-674
    • Foulis, A.K.1
  • 15
    • 0023749553 scopus 로고
    • The pancreas in idiopathic Addison's disease - A search for a prediabetic pancreas
    • Foulis AK, Jackson R, Farquharson MA. The pancreas in idiopathic Addison's disease: a search for a prediabetic pancreas. Histopathology 1988; 12:481-490. (Pubitemid 18186294)
    • (1988) Histopathology , vol.12 , Issue.5 , pp. 481-490
    • Foulis, A.K.1    Jackson, R.2    Farquharson, M.A.3
  • 16
    • 34548397755 scopus 로고    scopus 로고
    • Screening for insulitis in adult autoantibody: Positive organ donors
    • In't Veld P, Lievens D, De Grijse J, et al. Screening for insulitis in adult autoantibody: positive organ donors. Diabetes 2007; 56:2400-2404.
    • (2007) Diabetes , vol.56 , pp. 2400-2404
    • In'T Veld, P.1    Lievens, D.2    De Grijse, J.3
  • 17
    • 67651100160 scopus 로고    scopus 로고
    • Analysis of pancreas tissue in a child positive for islet cell antibodies
    • This work, as has others, also supports the notion that insulitis is rare in non-T1D subjects who possess only a single autoantibody but in addition, notes interesting findings (not discussed within this review) that infection of pancreatic islet cells with enterovirus was present in this individual
    • Oikarinen M, Tauriainen S, Honkanen T, et al. Analysis of pancreas tissue in a child positive for islet cell antibodies. Diabetes Care 2008; 31:1741-1742. This work, as has others, also supports the notion that insulitis is rare in non-T1D subjects who possess only a single autoantibody but in addition, notes interesting findings (not discussed within this review) that infection of pancreatic islet cells with enterovirus was present in this individual.
    • (2008) Diabetes Care , vol.31 , pp. 1741-1742
    • Oikarinen, M.1    Tauriainen, S.2    Honkanen, T.3
  • 18
    • 67651095286 scopus 로고    scopus 로고
    • Retrospective assessment of islet cell autoantibodies in pancreas organ donors
    • This work is very important with respect to the notion of whether a pancreas from an autoantibody positive individual, presumably 'compromised' by immune events, would function in a less than ideal fashion once transplanted; a notion that was not supported by the data in this report
    • Diamantopoulos S, Allende G, Ferreira JM, et al. Retrospective assessment of islet cell autoantibodies in pancreas organ donors. Diabetologia 2008; 51:703-713. This work is very important with respect to the notion of whether a pancreas from an autoantibody positive individual, presumably 'compromised' by immune events, would function in a less than ideal fashion once transplanted; a notion that was not supported by the data in this report.
    • (2008) Diabetologia , vol.51 , pp. 703-713
    • Diamantopoulos, S.1    Allende, G.2    Ferreira, J.M.3
  • 19
    • 67651095283 scopus 로고    scopus 로고
    • Beta-cell mass and type 1 diabetes: Going, going, gone?
    • Akirav E, Kushner JA, Herold KC. Beta-cell mass and type 1 diabetes: going, going, gone? J Mol Histol 2008; 39:543-551.
    • (2008) J Mol Histol , vol.39 , pp. 543-551
    • Akirav, E.1    Kushner, J.A.2    Herold, K.C.3
  • 20
  • 21
    • 38949113134 scopus 로고    scopus 로고
    • Extent of beta cell destruction is important but insufficient to predict the onset of type 1 diabetes mellitus
    • An interesting meta-analysis that draws to the forefront, the question of, 'what percentage of b cells are destroyed at the symptomatic onset of T1D?'
    • Klinke DJ. Extent of beta cell destruction is important but insufficient to predict the onset of type 1 diabetes mellitus. PLoS ONE 2008; 3:e1374. An interesting meta-analysis that draws to the forefront, the question of, 'what percentage of b cells are destroyed at the symptomatic onset of T1D?'.
    • (2008) PLoS ONE , vol.3
    • Klinke, D.J.1
  • 22
    • 27744526661 scopus 로고    scopus 로고
    • Pancreatic regeneration in type 1 diabetes: Dreams on a deserted islet?
    • Atkinson MA, Rhodes CJ. Pancreatic regeneration in type 1 diabetes: dreams on a deserted islet? Diabetologia 2005; 48:2200-2202.
    • (2005) Diabetologia , vol.48 , pp. 2200-2202
    • Atkinson, M.A.1    Rhodes, C.J.2
  • 23
    • 27744603796 scopus 로고    scopus 로고
    • Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: Indirect evidence for islet regeneration?
    • Meier JJ, Bhushan A, Butler AE, et al. Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration? Diabetologia 2005; 48:2221-2228.
    • (2005) Diabetologia , vol.48 , pp. 2221-2228
    • Meier, J.J.1    Bhushan, A.2    Butler, A.E.3
  • 24
    • 33745788583 scopus 로고    scopus 로고
    • Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes
    • Meier JJ, Lin JC, Butler AE, et al. Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes. Diabetologia 2006; 49:1838-1844.
    • (2006) Diabetologia , vol.49 , pp. 1838-1844
    • Meier, J.J.1    Lin, J.C.2    Butler, A.E.3
  • 25
    • 34347373445 scopus 로고    scopus 로고
    • Hematopoietic stem cells derived from adult donors are not a source of pancreatic β-cells in adult nondiabetic humans
    • DOI 10.2337/db06-1385
    • Butler AE, Huang A, Rao PN, et al. Hematopoietic stem cells derived from adult donors are not a source of pancreatic beta-cells in adult nondiabetic humans. Diabetes 2007; 56:2400-2404. (Pubitemid 47025449)
    • (2007) Diabetes , vol.56 , Issue.7 , pp. 1810-1816
    • Butler, A.E.1    Huang, A.2    Rao, P.N.3    Bhushan, A.4    Hogan, W.J.5    Rizza, R.A.6    Butler, P.C.7
  • 26
    • 67651084804 scopus 로고    scopus 로고
    • Diabetes. Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans
    • Meier JJ, Butler AE, Saisho Y, et al. Diabetes. Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. Diabetologia 2007; 56:1810-1816.
    • (2007) Diabetologia , vol.56 , pp. 1810-1816
    • Meier, J.J.1    Butler, A.E.2    Saisho, Y.3
  • 27
    • 58149470614 scopus 로고    scopus 로고
    • Pancreatic adenocarcinoma patients with localised chronic severe pancreatitis show an increased number of single beta cells, without alterations in fractional insulin area
    • With therapeutic trials using growth factors as a means to induce β cell replication in settings of T1D, evidence from humans that localized production of such factors (e.g., gastrin) is capable of inducing such activities is of interest
    • Campbell-Thompson M, Dixon LR, Wasserfall C, et al. Pancreatic adenocarcinoma patients with localised chronic severe pancreatitis show an increased number of single beta cells, without alterations in fractional insulin area. Diabetologia 2009; 52:262-270. With therapeutic trials using growth factors as a means to induce β cell replication in settings of T1D, evidence from humans that localized production of such factors (e.g., gastrin) is capable of inducing such activities is of interest.
    • (2009) Diabetologia , vol.52 , pp. 262-270
    • Campbell-Thompson, M.1    Dixon, L.R.2    Wasserfall, C.3
  • 28
    • 57349112286 scopus 로고    scopus 로고
    • Generation and regeneration of cells of the liver and pancreas
    • With controversies abounding in studies of pancreatic regeneration in mouse versus humans, this work provides an important evolutionary evaluation of questions relevant to the concept
    • Zaret KS, Grompe M. Generation and regeneration of cells of the liver and pancreas. Science 2008; 322:1490-1494. With controversies abounding in studies of pancreatic regeneration in mouse versus humans, this work provides an important evolutionary evaluation of questions relevant to the concept.
    • (2008) Science , vol.322 , pp. 1490-1494
    • Zaret, K.S.1    Grompe, M.2
  • 29
    • 41849097354 scopus 로고    scopus 로고
    • Beta cell mass in diabetes: A realistic therapeutic target?
    • An excellent overview of the means by which b cell replication/ regeneration may, or may not, be approached in diabetes
    • Meier JJ. Beta cell mass in diabetes: a realistic therapeutic target? Diabetologia 2008; 51:703-713. An excellent overview of the means by which b cell replication/regeneration may, or may not, be approached in diabetes.
    • (2008) Diabetologia , vol.51 , pp. 703-713
    • Meier, J.J.1
  • 30
    • 67651121203 scopus 로고    scopus 로고
    • Type 1 diabetes as a relapsing-remitting disease?
    • This work is interesting in its bringing to the forefront the notion that rather than a 'linear loss' in b cells numbers prior to the symptomatic onset of T1D, period of exacerbation and remission from the disease may occur
    • von Herrath M, Sanda S, Herold K. Type 1 diabetes as a relapsing-remitting disease? Nat Clin Pract Endo Metab 2007; 3:758-768. This work is interesting in its bringing to the forefront the notion that rather than a 'linear loss' in b cells numbers prior to the symptomatic onset of T1D, period of exacerbation and remission from the disease may occur.
    • (2007) Nat Clin Pract Endo Metab , vol.3 , pp. 758-768
    • Von Herrath, M.1    Sanda, S.2    Herold, K.3
  • 31
    • 62449183526 scopus 로고    scopus 로고
    • 11C-Dihydrotetrabenazine PET of the Pancreas in Subjects with Long-Standing Type 1 Diabetes and in Healthy Controls
    • An important follow-up, in humans, to a proof-of-principle study performed in rats suggesting that PET imaging of the pancreas (capable of reflecting β cell function) was feasible
    • Goland R, Freeby M, Parsey R, et al. 11C-Dihydrotetrabenazine PET of the Pancreas in Subjects with Long-Standing Type 1 Diabetes and in Healthy Controls. J Nucl Med 2009; 50:382-398. An important follow-up, in humans, to a proof-of-principle study performed in rats suggesting that PET imaging of the pancreas (capable of reflecting β cell function) was feasible.
    • (2009) J Nucl Med , vol.50 , pp. 382-398
    • Goland, R.1    Freeby, M.2    Parsey, R.3
  • 32
    • 67651104029 scopus 로고    scopus 로고
    • Relationship between pancreatic vesicular monoamine transporter 2 (VMAT2) and insulin expression in human pancreas
    • Saisho Y, Harris PE, Butler AE, et al. Relationship between pancreatic vesicular monoamine transporter 2 (VMAT2) and insulin expression in human pancreas. Diabetologia 2008; 51:1796-1802.
    • (2008) Diabetologia , vol.51 , pp. 1796-1802
    • Saisho, Y.1    Harris, P.E.2    Butler, A.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.