Collagen degradation in the abdominal aneurysm: A conspiracy of matrix metalloproteinase and cysteine collagenases

American Journal of Pathology

Volumn 170, Issue 3, 2007, Pages 809-817

  Abdul Hussien, Hazem ^a   Soekhoe, Ratna G V ^a   Weber, Ekkehard ^c   Von Der Thüsen, Jan H ^a   Kleemann, Robert ^b   Mulder, Adri ^a   Hajo Van Bockel, J ^a   Hanemaaijer, Roeland ^b   Lindeman, Jan H N ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b TNO   (Netherlands)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN K; CATHEPSIN L; CATHEPSIN S; CYSTATIN C; MATRIX METALLOPROTEINASE; NEUTROPHIL COLLAGENASE; COLLAGEN; COLLAGENASE; CYSTEINE; MESSENGER RNA; PROTEINASE INHIBITOR;

ABDOMINAL AORTA ANEURYSM; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLLAGEN DEGRADATION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROTEIN ANALYSIS; WESTERN BLOTTING; ENZYMOLOGY; IMMUNOHISTOCHEMISTRY; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGED; AORTIC ANEURYSM, ABDOMINAL; BLOTTING, WESTERN; COLLAGEN; COLLAGENASES; CYSTEINE; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MATRIX METALLOPROTEINASES; PROTEASE INHIBITORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 34247868280     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2007.060522     Document Type: Article

References (51)

1. Thompson RW, Geraghty PJ, Lee JK: Abdominal aortic aneurysms: basic mechanisms and clinical implications. Curr Probl Surg 2002, 39:110-230
2. Powell JT, Greenhalgh RM: Clinical practice. Small abdominal aortic aneurysms. N Engl J Med 2003, 348:1895-1901
3. Wassef M, Baxter BT, Chisholm RL, Dalman RL, Fillinger MF, Heinecke J, Humphrey JD, Kuivaniemi H, Parks WC, Pearce WH, Platsoucas CD, Sukhova GK, Thompson RW, Tilson MD, Zarins CK: Pathogenesis of abdominal aortic aneurysms: a multidisciplinary research program supported by the National Heart, Lung, and Blood Institute. J Vasc Surg 2001, 34:730-738
4. Dobrin PB, Banker WH, Gley WC: Elastolytic and collagenolytic studies of arteries. Implications for the mechanical properties of aneurysms. Arch Surg 1984, 119:405-409
5. MacSweeney ST, Young G, Greenhalgh RM, Powell JT: Mechanical properties of the aneurysmal aorta. Br J Surg 1992, 79:1281-1284
6. He CM, Roach MR: The composition and mechanical properties of abdominal aortic aneurysms. J Vasc Surg 1994, 20:6-13
7. Shingleton WD, Hodges DJ, Brick P, Cawston TE: Collagenase: a key enzyme in collagen turnover. Biochem Cell Biol 1996, 74:759-775
8. Aznavoorian S, Moore BA, Alexander-Lister LD, Hallit SL, Windsor LJ, Engler JA: Membrane type I-matrix metalloproteinase-mediated degradation of type I collagen by oral squamous cell carcinoma cells. Cancer Res 2001, 61:6264-6275
9. Kafienah W, Bromme D, Buttle DJ, Croucher LJ, Hollander AP: Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix. Biochem J 1998, 331:727-732
10. Garnero P, Borel O, Byrjalsen I, Mercedes Ferreras M, Drake FH, McQueney MS, Foged NT, Delmas PD, Delaisse JM: The collagenolytic activity of cathepsin K is unique among mammalian proteinases. J Biol Chem 1998, 273:32347-32352
11. Reddy GK, Dhar SC: Purification and characterization of collagenolytic property of renal cathepsin L from arthritic rat. Int J Biochem 1992, 24:1465-1473
12. Chapman HA, Riese RJ, Shi GP: Emerging roles for cysteine proteases in human biology. Annu Rev Physiol 1997, 59:63-88
13. Busuttil RW, Abou-Zamzam AM, Machleder HI: Collagenase activity of the human aorta. A comparison of patients with and without abdominal aortic aneurysms. Arch Surg 1980, 115:1373-1378
14. Powell J, Greenhalgh RM: Cellular, enzymatic, and genetic factors in the pathogenesis of abdominal aortic aneurysms. J Vasc Surg 1989, 9:297-304
15. Ailawadi G, Eliason JL, Upchurch Jr GR: Current concepts in the pathogenesis of abdominal aortic aneurysm. J Vasc Surg 2003, 38:584-588
16. Verheijen JH, Nieuwenbroek NME, Beekman B, Hanemaaijer R, Verspaget HW, Ronday HK, Bakker AHF: Modified proenzymes as artificial substrates for proteolytic enzymes: colorimetric assay of bacterial collagenase and matrix metalloproteinase activity using modified pro-urokinase. Biochem J 1997, 323:603-609
17. Lindeman JH, Hanemaaijer R, Mulder A, Dijkstra PD, Szuhai K, Bromme D, Verheijen JH, Hogendoorn PC: Cathepsin K is the principal protease in giant cell tumor of bone. Am J Pathol 2004, 165:593-600
18. Kleemann R, Gervois PP, Verschuren L, Staels B, Princen HM, Kooistra T: Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation. Blood 2003, 101:545-551
19. Inahara T: Eversion endarterectomy for aortoiliofemoral occlusive disease. A 16 year experience. Am J Surg 1979, 138:196-204
20. Carmeliet P: Proteinases in cardiovascular aneurysms and rupture: targets for therapy? J Clin Invest 2000, 105:1519-1520
21. Higashikata T, Yamagishi M, Sasaki H, Minatoya K, Ogino H, Ishibashi-Ueda H, Hao H, Nagaya N, Tomoike H, Sakamoto A: Application of real-time RT-PCR to quantifying gene expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human abdominal aortic aneurysm. Atherosclerosis 2004, 177:353-360
22. Wilson WR, Schwalbe EC, Jones JL, Bell PR, Thompson MM: Matrix metalloproteinase 8 (neutrophil collagenase) in the pathogenesis of abdominal aortic aneurysm. Br J Surg 2005, 92:828-833
23. Tamarina NA, McMillan WD, Shively VP, Pearce WH: Expression of matrix metalloproteinases and their inhibitors in aneurysms and normal aorta. Surgery 1997, 122:264-271
24. Tromp G, Gatalica Z, Skunca M, Berguer R, Siegel T, Kline RA, Kuivaniemi H: Elevated expression of matrix metalloproteinase-13 in abdominal aortic aneurysms. Ann Vasc Surg 2004, 18:414-420
25. Nishimura K, Ikebuchi M, Kanaoka Y, Ohgi S, Ueta E, Nanba E, Ito H: Relationships between matrix metalloproteinases and tissue inhibitor of metalloproteinases in the wall of abdominal aortic aneurysms. Int Angiol 2003, 22:229-238
26. Liu J, Sukhova GK, Yang JT, Sun J, Ma L, Ren A, Xu WH, Fu H, Dolganov GM, Hu C, Libby P, Shi GP: Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells. Atherosclerosis 2006, 184:302-311
27. Turk B, Turk D, Turk V: Lysosomal cysteine proteases: more than scavengers. Biochim Biophys Acta 2000, 1477:98-111
28. Khanna-Gupta A, Zibello T, Idone V, Sun H, Lekstrom-Himes J, Berliner N: Human neutrophil collagenase expression is C/EBP-dependent during myeloid development. Exp Hematol 2005, 33:42-52
29. Granelli-Piperno A, Vassalli JD, Reich E: RNA and protein synthesis in human peripheral blood polymorphonuclear leukocytes. J Exp Med 1979, 149:284-289
30. Garcia-Touchard A, Henry TD, Sangiorgi G, Spagnoli LG, Mauriello A, Conover C, Schwartz RS: Extracellular proteases in atherosclerosis and restenosis. Arterioscler Thromb Vasc Biol 2005, 25:1119-1127
31. Motyckova G, Fisher DE: Pycnodysostosis: role and regulation of cathepsin K in osteoclast function and human disease. Curr Mol Med 2002, 2:407-421
32. Urbich C, Heeschen C, Aicher A, Sasaki K, Bruhl T, Farhadi MR, Vajkoczy P, Hofmann WK, Peters C, Pennacchio LA, Abolmaali ND, Chavakis E, Reinheckel T, Zeiher AM, Dimmeler S: Cathepsin L is required for endothelial progenitor cell-induced neovascularization. Nat Med 2005, 11:206-213
33. Liu J, Sukhova GK, Sun JS, Xu WH, Libby P, Shi GP: Lysosomal cysteine proteases in atherosclerosis. Arterioscler Thromb Vasc Biol 2004, 24:1359-1366
34. Garnero P, Ferreras M, Karsdal MA, Nicamhlaoibh R, Risteli J, Borel O, Qvist P, Delmas PD, Foged NT, Delaisse JM: The type I collagen fragments ICTP and CTX reveal distinct enzymatic pathways of bone collagen degradation. J Bone Miner Res 2003, 18:859-867
35. Yasuda Y, Li Z, Greenbaum D, Bogyo M, Weber E, Brömme D: Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages. J Biol Chem 2004, 279:36761-36770
36. McQueney MS, Amegadzie BY, D'Alessio K, Hanning CR, McLaughlin MM, McNulty D, Carr SA, Ijames C, Kurdyla J, Jones CS: Autocatalytic activation of human cathepsin K. J Biol Chem 1997, 272:13955-13960
37. Menard R, Carmona E, Takebe S, Dufour E, Plouffe C, Mason P, Mort JS: Autocatalytic processing of recombinant human procathepsin L. Contribution of both intermolecular and unimolecular events in the processing of procathepsin L in vitro. J Biol Chem 1998, 273:4478-4484
38. Turk B, Dolenc I, Turk V, Bieth JG: Kinetics of the pH-induced inactivation of human cathepsin L. Biochemistry 1993, 32:375-380
39. Dehrmann FM, Coetzer TH, Pike RN, Dennison C: Mature cathepsin L is substantially active in the ionic milieu of the extracellular medium. Arch Biochem Biophys 1995, 324:93-98
40. Bromme D, Okamoto K, Wang BB, Biroc S: Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts. Functional expression of human cathepsin O2 in Spodoptera frugiperda and characterization of the enzyme. J Biol Chem 1996, 271:2126-2132
41. Blair HC, Teitelbaum SL, Ghiselli R, Gluck S: Osteoclastic bone resorption by a polarized vacuolar proton pump. Science 1989, 245:855-857
42. Shi GP, Sukhova GK, Grubb A, Ducharme A, Rhode LH, Lee RT, Ridker PM, Libby P, Chapman HA: Cystatin C deficiency in human atherosclerosis and aortic aneurysms. J Clin Invest 1999, 104:1191-1197
43. Lindholt JS, Erlandsen EJ, Henneberg EW: Cystatin C deficiency is associated with the progression of small abdominal aortic aneurysms. Br J Surg 2001, 88:1472-1475
44. Parks WC: A confederacy of proteinases. J Clin Invest 2002, 110:613-614
45. Liu Z, Zhou X, Shapiro SD, Shipley JM, Twining SS, Diaz LA, Senior RM, Werb Z: The serpin α1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo. Cell 2000, 102:647-655
46. Eliason JL, Hannawa KK, Ailawadi G; Sinha I, Ford JW, Deogracias MP, Roelofs KJ, Woodrum DT, Ennis TL, Henke PK, Stanley JC, Thompson RW, Upchurch, Jr GR: Neutrophil depletion inhibits experimental abdominal aortic aneurysm formation. Circulation 2005, 112:232-240
47. Wilson WR, Anderton M, Schwalbe EC, Jones JL, Furness PN, Bell PR, Thompson MM: Matrix metalloproteinase-8 and -9 are increased at the site of abdominal aortic aneurysm rupture. Circulation 2006, 113:438-445
48. Defawe OD, Colige A, Lambert CA, Delvenne P, Lapiere ChM, Limet R, Nusgens BV, Sakalihasan N: Gradient of proteolytic enzymes, their inhibitors and matrix proteins expression in a ruptured abdominal aortic aneurysm. Eur J Clin Invest 2004, 34:513-514
49. Yasuda Y, Kaleta J, Bromme D: The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics. Adv Drug Deliv Rev 2005, 57:973-993
50. Morgan MD, Harper L, Lu X, Nash G, Williams J, Savage CO: Can neutrophils be manipulated in vivo? Rheumatology (Oxford) 2005, 44:597-601
51. Baxter BT: Could medical intervention work for aortic aneurysms? Am J Surg 2004, 188:628-632