Glucans exhibit weak antioxidant activity, but stimulate macrophage free radical activity

Free Radical Biology and Medicine

Volumn 30, Issue 4, 2001, Pages 393-402

  Tsiapali, Ekaterini ^a   Whaley, Sarah ^a   Kalbfleisch, John ^a   Ensley, Harry E ^a,b   Browder, I William ^a   Williams, David L ^a  

^a East Tennessee State University   (United States)

^b Tulane University   (United States)

Author keywords

Antioxidant; Carbohydrate; Free radicals; Glucan; Macrophage; Polymer

Indexed keywords

(1-3) BETA DEXTRO GLUCAN; ANTIOXIDANT; CARBOHYDRATE; DEXTRAN; FREE RADICAL; GLUCAN; GLUCOSE; LAMINARAN; LIPOPOLYSACCHARIDE; MANNAN; MONOSACCHARIDE; POLYMER; PULLULAN; PYRROLIDINE DITHIOCARBAMATE; SCAVENGER; SCHIZOPHYLLAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; INFLAMMATION; MACROPHAGE; MACROPHAGE ACTIVATION; MODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIOXIDANTS; CELL LINE; FLOW CYTOMETRY; FREE RADICALS; GLUCANS; MACROPHAGES; MICE; SPECTROMETRY, FLUORESCENCE;

LETHRINIDAE; MURINAE;

EID: 0035865904     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(00)00485-8     Document Type: Article

References (48)

1. Glucan-based macrophage stimulators: A review of their anti-infective potential
2. NMR spectral analysis of a water-insoluble (1→3)-β-D-glucan isolated from Saccharomyces cerevisiae
3. Identification of phosphate substitution sites by NMR spectroscopy in a water-soluble phosphorylated (1→3)-β-D-glucan
4. Beneficial effect of enhanced macrophage function in the trauma patient
5. A Phase II multicenter, double-blind, randomized, placebo-controlled study of three dosages of an immunomodulator (pgg-glucan) in high-risk surgical patients
6. Randomized phase I/II trial of a macrophage-specific immunomodulator (PGG-glucan) in high-risk surgical patients
7. Effect of glucan on neutrophil dynamics and immune function in Escherichia coli peritonitis
8. Immunotherapeutic modification of Escherichia coli-induced experimental peritonitis and bacteremia by glucan
9. Synergistic effect of nonspecific immunostimulation and antibiotics in experimental peritonitis
10. Anti-infective effect of poly-β1-6-glucotriosyl-β1-3-glucopyranose glucan in vivo
11. Polysaccharide-mediated protection against abscess formation in experimental intra-abdominal sepsis
12. Isolation, physicochemical characterization and preclinical efficacy evaluation of soluble scleroglucan
13. Ligand binding to the (1→3)-β-D-glucan receptor stimulates NFκB activation, but not apoptosis in U937 cells
14. PGG-glucan activates NF-κB-like and NF-IL-6-like transcription factor complexes in a murine monocytic cell line
15. Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma
16. Blockade of tumor necrosis factor reduces lipoplysaccharide lethality, but not the lethality of cecal ligation and puncture
17. Pulmonary and hepatic gene expression following cecal ligation and puncture: Monophosphoryl lipid A prophylaxis attenuates sepsis-induced cytokine and chemokine expression and neutrophil infiltration
18. Inhibiting early activation of tissue nuclear factor-κB and nuclear factor interleukin 6 with (1→3)-β-D-glucan increases long-term survival in polymicrobial sepsis
19. Overview of (1→3)-β-D-glucan immunobiology
20. Polysaccharides in fungi. XIV. Anti-inflammatory effect of the polysaccharides from the fruit bodies of several fungi
21. Anti-inflammatory effect of the polysaccharide from the fruit bodies of Auricularia species
22. Anti-inflammatory activity and conformational behavior of a branched (1→3)-β-D-glucan from an alkaline extract of Dictyophora indusiata fisch
23. Fungal β-glucans modulate macrophage release of tumor necrosis factor-α in response to bacterial lipopolysaccharide
24. Down-regulation of tumor necrosis factor-alpha, moderate reduction of interleukin-1beta, but not interleukin-6 or interleukin-10, by glucan immunodulators curdlan sulfate and lentinan
25. Glucan: Mechanisms involved in its "radioprotective" effect
26. 2 Scavenging activity of lignins, tannins and PSK
27. Carboxymethylated glucan inhibits lipid peroxidation in liposomes
28. The influence of glucan polymer structure and solution conformation on binding to (1→3)-β-D-glucan receptors in a human monocyte-like cell line
29. Phycoerythrin fluorescence-based assay for reactive oxygen species
30. Oxygen-radical absorbance capacity assay for antioxidants
31. A method for the solubilization of a (1→3)-β-D-glucan isolated from Saccharomyces cerevisiae
32. Development, physicochemical characterization and preclinical efficacy evaluation of a water soluble glucan sulfate derived from Saccharomyces cerevisiae
33. Development of a water-soluble, sulfated (1→3)-β-D-glucan biological response modifier derived from Saccharomyces cerevisiae
34. Comparison of the carbohydrate biological response modifiers Krestin, schizophyllan and glucan phosphate by aqueous size exclusion chromatography with in-line argon-ion multi-angle laser light scattering photometry and differential viscometry detectors
35. Receptor binding and internalization of water-soluble (1→3)-β-D-glucan biologic response modifier in two monocyte/macrophage cell lines
36. Inhibition of LPS induced NFκB activation by a glucan ligand involves down regulation of IKKβ kinase activity and altered phosphorylation and degradation of IκBα
37. Quantifying cellular oxidative stress by dichlorofluourescein assay using microplate reader
38. Lactoferrin inhibits the binding of lipopolysaccharides to L-selectin and subsequent production of reactive oxygen species by neutrophils
39. The effect of molecular weight and beta-1,6-linkages on priming of macrophage function in mice by (1,3)-beta-D-glucan
40. Crystal morphology of precipitated mannan
41. An electron diffraction study of mannan I. Crystal and molecular structure
42. Polysaccharides of Baker's yeast. Part IV. Mannan
43. Gel point in physical gels: Rheology and light scattering from thermoreversibly gelling schizophyllan
44. Molecular structure of lipid A, the endotoxic center of bacterial lipopolysaccharides
45. Affinities of different proteins and peptides for lipopolysaccharide as determined by biosensor technology
46. Dimethyl sulfoxide modulates NF-kB and cytokine activation in lipopolysaccharide-treated murine macrophages
47. Early activation of hepatic NFkB and NF-IL6 in polymicrobial sepsis correlates with bacteremia, cytokine expression and mortality
48. 3H-SPG in sarcoma-180 inoculated females between ICR and DBA mice