AD-1, a novel ginsenoside derivative, shows anti-lung cancer activity via activation of p38 MAPK pathway and generation of reactive oxygen species

Biochimica et Biophysica Acta - General Subjects

Volumn 1830, Issue 8, 2013, Pages 4148-4159

  Zhang, Lin Hui ^a,b   Jia, Yong Liang ^a,b   Lin, Xi Xi ^a   Zhang, Hong Quan ^b   Dong, Xin Wei ^a   Zhao, Jun Ming ^d   Shen, Jian ^a   Shen, Hui Juan ^a   Li, Fen Fen ^a   Yan, Xiao Feng ^a   Li, Wei ^c   Zhao, Yu Qing ^c   Xie, Qiang Min ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b YANGZHOU UNIVERSITY   (China)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^d Liaoning Xinzhong Modern Medicine Co Ltd   (China)

Author keywords

AD 1; Apoptosis; Cell cycle; Ginsenoside; Lung cancer; Signaling pathway

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; AD 1; ANTINEOPLASTIC AGENT; CARBOPLATIN; CD34 ANTIGEN; CISPLATIN; GELATINASE B; GINSENOSIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BODY WEIGHT; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CELL STRAIN; CELL STRAIN A549; CELL STRAIN H292; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; G0 PHASE CELL CYCLE CHECKPOINT; G1 PHASE CELL CYCLE CHECKPOINT; GENE SILENCING; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; LUNG CANCER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; UPREGULATION;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; CELLS, CULTURED; GINSENOSIDES; HUMANS; LUNG NEOPLASMS; MALE; MAP KINASE SIGNALING SYSTEM; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES;

MUS; MUS MUSCULUS; PANAX GINSENG;

EID: 84877810697     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2013.04.008     Document Type: Article

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