The role of MAPK and Nrf2 pathways in ketanserin-elicited attenuation of cigarette smoke-induced induced iL-8 production in human bronchial epithelial cells

Toxicological Sciences

Volumn 125, Issue 2, 2012, Pages 569-577

  Lau, Way Kwok Wai ^a   Chan, Stanley Chi Hang ^a   Law, Andrew Chi Kin ^a   Ip, Mary Sau Man ^a   Mak, Judith Choi Wo ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Chronic obstructive pulmonary disease; Cigarette smoke; Human bronchial epithelial cells; Interleukin 8; Serotonin

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CIGARETTE SMOKE; GLUTATHIONE; GLUTATHIONE DISULFIDE; INTERLEUKIN 8; KETANSERIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BRONCHUS MUCOSA; CELL LINE; CELL NUCLEUS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOSE RESPONSE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; GENE SILENCING; GENE TRANSLOCATION; HUMAN; HUMAN CELL; IN VITRO STUDY; NORMAL HUMAN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 84856082183     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr305     Document Type: Article

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