Ghrelin inhibits BSCB disruption/hemorrhage by attenuating MMP-9 and SUR1/TrpM4 expression and activation after spinal cord injury

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1842, Issue 12, 2014, Pages 2403-2412

  Lee, Jee Y ^a   Choi, Hae Y ^a   Na, Won H ^b   Ju, Bong G ^b   Yune, Tae Y ^a  

^a Kyung Hee University Hospital   (South Korea)

^b Sogang University   (South Korea)

Author keywords

Blood spinal cord barrier; Ghrelin; Hemorrhage; Matrix metalloprotease; Sulfonylurea receptor 1; Transient receptor potential melastatin 4

Indexed keywords

AUTACOID; CXCL2 CHEMOKINE; CYCLOOXYGENASE 2; GELATINASE A; GELATINASE B; GHRELIN; GHRELIN RECEPTOR; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; SULFONYLUREA RECEPTOR 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL M4; TUMOR NECROSIS FACTOR ALPHA; ABCC8 PROTEIN, RAT; GHRP-6, LYS(3)-; OLIGOPEPTIDE; SULFONYLUREA RECEPTOR; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM4 PROTEIN, RAT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SPINAL CORD BARRIER; BLOOD VESSEL; CELL INFILTRATION; CONTROLLED STUDY; DOWN REGULATION; DRUG MEGADOSE; ENZYME ACTIVATION; ENZYME INHIBITION; EXPERIMENTAL SPINAL CORD CONTUSION; MACROPHAGE; MALE; NEUROPROTECTION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PERMEABILITY BARRIER; PROTEIN EXPRESSION; RAT; SPINAL CORD HEMORRHAGE; SPINAL CORD INJURY; UPREGULATION; WEIGHT REDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CAPILLARY PERMEABILITY; DRUG EFFECTS; GENE EXPRESSION; GENETICS; HEMORRHAGE; IMMUNOHISTOCHEMISTRY; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; NEUTROPHIL; PATHOPHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD; SPRAGUE DAWLEY RAT; TIME; VASCULARIZATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CAPILLARY PERMEABILITY; GENE EXPRESSION; GHRELIN; HEMORRHAGE; IMMUNOHISTOCHEMISTRY; INFLAMMATION MEDIATORS; INJECTIONS, INTRAPERITONEAL; MACROPHAGES; MALE; MATRIX METALLOPROTEINASE 9; NEUTROPHILS; OLIGOPEPTIDES; RATS, SPRAGUE-DAWLEY; RECEPTORS, GHRELIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPINAL CORD; SPINAL CORD INJURIES; SULFONYLUREA RECEPTORS; TIME FACTORS; TRPM CATION CHANNELS;

EID: 84910069450     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2014.09.006     Document Type: Article

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