Fluoxetine inhibits transient global ischemia-induced hippocampal neuronal death and memory impairment by preventing blood-brain barrier disruption

Neuropharmacology

Volumn 79, Issue , 2014, Pages 161-171

  Lee, Jee Y ^a   Lee, Hyung E ^b   Kang, So R ^a   Choi, Hye Y ^a   Ryu, Jong H ^b   Yune, Tae Y ^a  

^a Kyung Hee University Hospital   (South Korea)

^b Kyung Hee University   (South Korea)

Author keywords

Blood spinal cord barrier; Global ischemia; Hippocampus; Matrix metalloprotease; Tight junction

Indexed keywords

AUTACOID; FLUOXETINE; GELATINASE A; GELATINASE B; LAMININ; MESSENGER RNA; OCCLUDIN; MMP2 PROTEIN, MOUSE; MMP9 PROTEIN, MOUSE; NEUROPROTECTIVE AGENT; OCLN PROTEIN, MOUSE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME INHIBITION; GENE EXPRESSION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LEARNING; MACROPHAGE ACTIVATION; MALE; MEMORY DISORDER; MICROGLIA; MOUSE; NERVE CELL NECROSIS; NERVE CELL NETWORK; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; VASCULAR ENDOTHELIUM; ANIMAL; CAPILLARY PERMEABILITY; CELL DEATH; DRUG EFFECTS; INBRED MOUSE STRAIN; MACROPHAGE; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULARIZATION;

ANIMALS; ASTROCYTES; BLOOD-BRAIN BARRIER; BRAIN ISCHEMIA; CAPILLARY PERMEABILITY; CELL DEATH; FLUOXETINE; GENE EXPRESSION; HIPPOCAMPUS; LAMININ; MACROPHAGES; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE, INBRED STRAINS; MICROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; OCCLUDIN; RNA, MESSENGER;

EID: 84890368028     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.11.011     Document Type: Article

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