Valproic acid attenuates blood-spinal cord barrier disruption by inhibiting matrix metalloprotease-9 activity and improves functional recovery after spinal cord injury

Journal of Neurochemistry

Volumn 121, Issue 5, 2012, Pages 818-829

  Lee, Jee Y ^a   Kim, Hwang S ^a   Choi, Hye Y ^a   Oh, Tae H ^a   Ju, Bong G ^b   Yune, Tae Y ^a,c  

^a Kyung Hee University   (South Korea)

^b Sogang University   (South Korea)

^c Kyung Hee University Hospital   (South Korea)

Author keywords

blood spinal cord barrier; histone deacetylase inhibitor; inflammation; matrix metalloprotease; spinal cord injury; tight junction

Indexed keywords

CASPASE 3; GELATINASE A; GELATINASE B; HISTONE H3; MESSENGER RNA; OCCLUDIN; PROTEIN ZO1; TUMOR NECROSIS FACTOR ALPHA; VALPROIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD CELL; CELL DEATH; CELL INFILTRATION; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; IMMUNOREACTIVITY; MACROPHAGE; MALE; NEUROPROTECTION; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD INJURY; TIGHT JUNCTION; TREATMENT RESPONSE; UPREGULATION;

ANIMALS; BLOTTING, WESTERN; CAPILLARY PERMEABILITY; ENZYME-LINKED IMMUNOSORBENT ASSAY; HISTONE DEACETYLASE INHIBITORS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MATRIX METALLOPROTEINASE 9; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPINAL CORD INJURIES; VALPROIC ACID;

EID: 84860543143     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2012.07731.x     Document Type: Article

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