Chronic central ghrelin infusion reduces blood pressure and heart rate despite increasing appetite and promoting weight gain in normotensive and hypertensive rats

Peptides

Volumn 42, Issue , 2013, Pages 35-42

  Freeman, John N ^a   Carmo, Jussara M Do ^a   Adi, Ahmad H ^a   Da Silva, Alexandre A ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Baroreceptor function; Blood pressure; Food intake; Ghrelin; Heart rate; Leptin

Indexed keywords

GHRELIN;

ANIMAL EXPERIMENT; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; FOOD INTAKE; HEART RATE; INCREASED APPETITE; MALE; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SYMPATHETIC TONE; WEIGHT GAIN;

ANIMALS; BLOOD PRESSURE; BRADYCARDIA; EATING; GHRELIN; HEART RATE; INFUSIONS, INTRAVENTRICULAR; MALE; PRESSORECEPTORS; RATS; RATS, INBRED SHR; RATS, SPRAGUE-DAWLEY; WEIGHT GAIN;

EID: 84877267118     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2013.02.003     Document Type: Article

References (20)

1. V. Baudrie, D. Laude, and J.L. Elghozi Optimal frequency ranges for extracting information on cardiovascular autonomic control from blood pressure and pulse interval spectrograms in mice Am. J. Physiol. Regul. Integr. Comp. Physiol. 292 2007 R904 R912
2. M.L. Correia, D.A. Morgan, W.I. Sivitz, A.L. Mark, and W.G. Haynes Hemodynamic consequences of neuropeptide Y-induced obesity Am. J. Hypertens. 15 2002 137 142
3. D.E. Cummings, J.Q. Purnell, R.S. Frayo, K. Schmidova, B.E. Wisse, and D.S. Weigle A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans Diabetes 50 2001 1714 1719
4. D.M. Ferens, L. Yin, R. Bron, B. Hunne, K. Ohashi-Doi, and P.D. Kitchener Functional and in situ hybridization evidence that preganglionic sympathetic vasoconstrictor neurons express ghrelin receptors Neuroscience 166 2010 671 679
5. J.M. Frecka, and R.D. Mattes Possible entrainment of ghrelin to habitual meal patterns in humans Am. J. Physiol. Gastrointest. Liver Physiol. 294 2008 G699 G707
6. J.J. Hillebrand, D. de Wied, and R.A. Adan Neuropeptides, food intake and body weight regulation: a hypothalamic focus Peptides 23 2002 2283 2306
7. J.J. Kuo, A.A. Silva, and J.E. Hall Hypothalamic melanocortin receptors and chronic regulation of arterial pressure and renal function Hypertension 41 2003 768 774
8. J.J. Kuo, A.A. da Silva, L.S. Tallam, and J.E. Hall Role of adrenergic activity in pressor responses to chronic melanocortin receptor activation Hypertension 43 2004 370 375.
9. F. Lanfranco, G. Motta, M. Baldi, V. Gasco, S. Grottoli, and A. Benso Ghrelin and anterior pituitary function Front. Horm. Res. 38 2010 206 211
10. Y. Lin, K. Matsumura, M. Fukuhara, S. Kagiyama, K. Fujii, and M. Iida Ghrelin acts at the nucleus of the solitary tract to decrease arterial pressure in rats Hypertension 43 2004 977 982
11. K. Matsumura, T. Tsuchihashi, K. Fujii, I. Abe, and M. Iida Central ghrelin modulates sympathetic activity in conscious rabbits Hypertension 40 2002 694 699
12. N. Nagaya, M. Kojima, M. Uematsu, M. Yamagishi, H. Hosoda, and H. Oya Hemodynamic and hormonal effects of human ghrelin in healthy volunteers Am. J. Physiol. Regul. Integr. Comp. Physiol. 280 2001 R1483 R1487
13. N. Nagaya, K. Miyatake, M. Uematsu, H. Oya, W. Shimizu, and H. Hosoda Hemodynamic, renal, and hormonal effects of ghrelin infusion in patients with chronic heart failure J. Clin. Endocrinol. Metab. 86 2001 5854 5859
14. M. Nakazato, N. Murakami, Y. Date, M. Kojima, H. Matsuo, and K. Kangawa A role for ghrelin in the central regulation of feeding Nature 409 2001 194 198
15. R. Nogueiras, L.M. Williams, and C. Dieguez Ghrelin: new molecular pathways modulating appetite and adiposity Obes. Facts 3 2010 285 292
16. H.C. Nystrom, N. Klintland, K. Caidahl, G. Bergstrom, and A. Wickman Short-term administration of growth hormone (GH) lowers blood pressure by activating eNOS/nitric oxide (NO)-pathway in male hypophysectomized (Hx) rats BMC Physiol. 5 2005 17
17. L.S. Tallam, J.J. Kuo, A.A. da Silva, and J.E. Hall Cardiovascular, renal, and metabolic responses to chronic central administration of agouti-related peptide Hypertension 44 2004 853 858
18. L.S. Tallam, D.E. Stec, M.A. Willis, A.A. da Silva, and J.E. Hall Melanocortin-4 receptor-deficient mice are not hypertensive or salt-sensitive despite obesity, hyperinsulinemia, and hyperleptinemia Hypertension 46 2005 326 332
19. K.E. Wortley, K.D. Anderson, K. Garcia, J.D. Murray, L. Malinova, and R. Liu Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference Proc. Natl. Acad. Sci. U S A 101 2004 8227 8232
20. K.E. Wortley, J.P. del Rincon, J.D. Murray, K. Garcia, K. Iida, and M.O. Thorner Absence of ghrelin protects against early-onset obesity J. Clin. Invest. 115 2005 3393 3397