Should we consider the infusion of lipid emulsion in the resuscitation of poisoned patients?

Critical Care

Volumn 18, Issue 5, 2014, Pages

  Cave, Grant ^a   Harvey, Martyn G ^b  

^a Tamworth Rural Referral Hospital   (Australia)

^b WAIKATO HOSPITAL   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARDIOTOXIN; FATTY ACID; HYPERTENSIVE FACTOR; ION CHANNEL; LACTIC ACID; LIPID EMULSION;

ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; CONTINUOUS INFUSION; DRUG INTOXICATION; DRUG MECHANISM; DRUG SAFETY; FATTY ACID METABOLISM; FATTY ACID TRANSPORT; GASTROINTESTINAL ABSORPTION; HEART MUSCLE CELL; HUMAN; HYPERAMYLASEMIA; HYPERLIPIDEMIA; LACTATE BLOOD LEVEL; LIPID SOLUBILITY; LIPOPHILICITY; NONHUMAN; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESUSCITATION; SURVIVAL TIME; ANIMAL; DIAGNOSIS; DRUG THERAPY; INTOXICATION; METABOLISM; PROCEDURES; TRENDS;

ANIMALS; FAT EMULSIONS, INTRAVENOUS; HUMANS; POISONING; RESUSCITATION;

EID: 84910063544     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-014-0457-5     Document Type: Article

References (71)

1. Weinberg G, VadeBoncouer T, Ramaraju G, Garcia-Amaro M, Cwik M. Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology 1998, 88:1071-1075. 10.1097/00000542-199804000-00028, 9579517.
2. Weinberg G, Ripper R, Feinstein D, Hoffman W. Lipid emulsion infusion rescues dogs from bupivacaine induced cardiac toxicity. Reg Anesth Pain Med 2003, 28:198-202. 10.1097/00115550-200305000-00005, 12772136.
3. Krieglstein J, Meffert A, Niemeyer D. Influence of emulsified fat on clhorpromazine availability in rabbit blood. Experientia 1974, 15:924-926. 10.1007/BF01938365.
4. Rosenblatt M, Abel M, Fischer G, Itzkovich C, Eisenkraft J. Successful use of a 20 % lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology 2006, 105:217-218. 10.1097/00000542-200607000-00033, 16810015.
5. Sirianni A, Osterhoudt K, Calello D, Muller AA, Waterhouse MR, Goodkin MB, Weinberg GL, Henretig FM. Use of Intralipid in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine. Ann Emerg Med 2007, 51:412-415. 10.1016/j.annemergmed.2007.06.004, 17766009.
6. Harvey M, Cave G. Intravenous lipid emulsion as antidote beyond local anesthetic toxicity: a systematic review. Acad Emerg Med 2009, 16:815-824. 10.1111/j.1553-2712.2008.00313.x, 19845549.
7. Leelach R, Bern S, Oswald S, Weinberg G. Intavenous lipid emulsion in clinical toxicology. Scand J Trauma Resusc Emerg Med 2010, 18:51-59. 10.1186/1757-7241-18-51.
8. Jamaty C, Bailey B, Larocque A, Notebaert E, Sanogo K, Chauny JM. Lipid emulsions in the treatment of acute poisoning: a systematic review of human and animal studies. Clin Toxicol 2010, 48:1-27. 10.3109/15563650903544124.
9. Cave G, Harvey M, Graudins A. Intravenous lipid emulsion as antidote: a summary of published human experience. Emerg Med Australas 2011, 23:123-141. 10.1111/j.1742-6723.2011.01398.x, 21489160.
10. Waring S. Intravenous lipid administration for drug-induced toxicity: a critical review of the existing data. Expert Rev Clin Pharmacol 2012, 5:437-444. 10.1586/ecp.12.27, 22943123.
11. Weinberg G, Ripper R, Murphy P, Edelman LB, Hoffman W, Strichartz G, Feinstein DL. Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart. Reg Anesth Pain Med 2006, 31:296-303. 10.1097/00115550-200607000-00004, 16857549.
12. Chen Y, Xia Y, Liu L, Shi T, Shi K, Wang Q, Chen L, Papadimos TJ, Xu X. Lipid emulsion reverses bupivacaine induced asystole in isolated rat hearts: concentration response and time response relationships. Anesthesiology 2010, 113:1320-1325. 10.1097/ALN.0b013e3181fc63ed, 21068661.
13. Shi K, Xia Y, Wang Q, Wu Y, Dong X, Chen C, Tang W, Zhang Y, Luo M, Wang X, Papadimos TJ, Xu X. The effect of lipid emulsion on pharmacokinetics and tissue distribution of bupivacaine in rats. Anesth Analg 2013, 116:804-809. 10.1213/ANE.0b013e318284123e, 23460566.
14. The Association of Anaesthetists of Great Britain and Ireland: Guidelines for the Management of Severe Local-Anaesthetic Toxicity. http://www.aagbi.org/publications/guidelines/docs/latoxicity07.pdf
15. Yoav G, Odelia G, Shaltiel C. A lipid emulsion reduces mortality from clomipramine overdose in rats. Vet Hum Toxicol 2002, 44:30. 11824772.
16. Bania T, Chu J. Hemodynamic effect of intralipid in amitriptyline toxicity. Acad Emerg Med 2006, 13(S1):117.
17. Harvey M, Cave G. Intralipid outperforms sodium bicarbonate in a rabbit model of clomipramine toxicity. Ann Emerg Med 2007, 49:178-185. 10.1016/j.annemergmed.2006.07.016, 17098328.
18. Boegevig S, Rothe A, Tfelt-Hansen J, Hoegberg LC. Successful reversal of life threatening cardiac effect following dosulepin overdose using intravenous lipid emulsion. Clin Toxicol 2011, 49:337-339. 10.3109/15563650.2011.566880.
19. ten Tusscher BL, Beishuizen A, Girbes AR, Swart EL, van Leeuwen RW. Intravenous fat emulsion therapy for intentional propafenone intoxication. Clin Toxicol 2011, 49:701. 10.3109/15563650.2011.597033.
20. Moussot PE, Marhar F, Minville V, Vallé B, Dehours E, Bounes V, Ducassé JL. Use of intravenous lipid emulsion for the treatment of a voluntary intoxication of flecainide with refractory shock. Clin Toxicol 2011, 49:514. 10.3109/15563650.2011.590940.
21. Arora NP, Berk WA, Aaron CK, Williams KA. Usefulness of intravenous lipid emulsion for cardiac toxicity from cocaine overdose. Am J Cardiol 2013, 111:445-447. 10.1016/j.amjcard.2012.10.022, 23186600.
22. Carriero S, Blum J, Hack JB. Pretreatment with intravenous lipid emulsion reduces mortality from cocaine toxicity in a rat model. Ann Emerg Med 2014, 64:32-37. 10.1016/j.annemergmed.2013.11.017.
23. Cave G, Harvey M, Quinn P, Heys D. Hypertonic sodium bicarbonate versus intravenous lipid emulsion in a rabbit model of intravenous flecanide toxicity: no difference, no sink. Clin Toxicol 2013, 51:394-397. 10.3109/15563650.2013.794282.
24. Jakkala-Saibaba R, Morgan PG, Morton GL. Treatment of cocaine overdose with lipid emulsion. Anaesthesia 2011, 66:1168-1170. 10.1111/j.1365-2044.2011.06895.x, 22074030.
25. Tebbutt S, Harvey M, Nicholson T, Cave G. Intralipid prolongs survival in a rat model of verapamil toxicity. Acad Emerg Med 2006, 13:134-139. 10.1111/j.1553-2712.2006.tb01661.x, 16436797.
26. Bania T, Chu J, Perez E. Hemodynamic effects of intravenous fat emulsion in an animal model of severe verapamil toxicity resuscitated with atropine, calcium, and saline. Acad Emerg Med 2007, 14:105-111. 10.1111/j.1553-2712.2007.tb01752.x, 17267527.
27. Perez E, Bania T, Medlej K, Chu J. Determining the optimal dose of intravenous fat emulsion for the treatment of severe verapamil toxicity in a rodent model. Acad Emerg Med 2009, 15:1284-1289. 10.1111/j.1553-2712.2008.00259.x.
28. Bania T, Chu J, Wesolowski M. The hemodynamic effect of Intralipid on propranolol toxicity. Acad Emerg Med 2006, 13(S1):109. 10.1197/j.aem.2006.03.268.
29. Harvey M, Cave G. Intralipid infusion ameliorates propranolol induced hypotension in rabbits. J Med Toxicol 2008, 4:71-76. 10.1007/BF03160958, 18570165.
30. Weinberg G, Di Gregorio G, Hiller D, Hewett A, Sirianni A. Reversal of haloperidol induced cardiac arrest by using lipid emulsion. Ann Int Med 2009, 19:737-738. 10.7326/0003-4819-150-10-200905190-00023.
31. Moshiri M, Vahabzadeh M, Mohammadpour A, Hosseinzadeh H. Evaluation of intravenous lipid emulsion on haloperidol induced hypotension in rabbits. Toxicol Ind Health 2014. [Epub ahead of print].
32. Niiya T, Litonius E, Petaja L, Neuvonen P, Rosenburg P. Intravenous lipid emulsion sequesters amiodarone in plasma and eliminates its hypotensive action in pigs. Ann Emerg Med 2010, 56:402-408. 10.1016/j.annemergmed.2010.06.001, 20868908.
33. French D, Smollin C, Ruan W, Wong A, Drasner K, Wu A. Partition constant and volume of distribution as predictors of clinical efficacy of lipid rescue for toxicologic emergencies. Clin Toxicol 2011, 49:801-809. 10.3109/15563650.2011.617308.
34. Harvey M, Cave G. Correlation of plasma and peritoneal diasylate clomipramine concentration with hemodynamic recovery after Intralipid infusion in rabbits. Acad Emerg Med 2009, 16:151-156. 10.1111/j.1553-2712.2008.00313.x, 19133855.
35. Litonius E, Niiya T, Neuvonen P, Rosenburg P. No antidotal effect of intravenous lipid emulsion in experimental amitriptyline intoxication despite significant entrapment of amitriptyline. Basic Clin Pharmacol Toxicol 2012, 110:378-383. 10.1111/j.1742-7843.2011.00826.x, 22023355.
36. Heinonen J, Litonius E, Backman J, Neuvonen P, Rosenburg P. Intravenous lipid emulsion entraps amitriptyline into plasma and can lower its brain concentration - an experimental intoxication study in pigs. Basic Clin Pharmacol Toxicol 2013, 113:193-200. 10.1111/bcpt.12082, 23639060.
37. Minton N, Goode A, Henry J. The effect of a lipid suspension on amitriptyline disposition. Arch Toxicol 1987, 60:467-469. 10.1007/BF00302392, 3662823.
38. Litonius E, Tarkkila P, Neuvonen P, Rosenburg P. Effect of intravenous lipid emulsion on bupivacaine plasma concentration in humans. Anaesthesia 2012, 67:600-605. 10.1111/j.1365-2044.2012.07056.x, 22352703.
39. French D, Armenian P, Ruan W, Wong A, Drasner K, Olson KR, Wu AH. Serum verapamil concentrations before and after intralipid therapy during treatment of an overdose. Clin Toxicol 2011, 49:340-344. 10.3109/15563650.2011.572556.
40. Harvey M, Cave G. Case report: successful lipid resuscitation in a multi-drug overdose with predominant tricyclic antidepressant toxidrome. Int J Emerg Med 2012, 5:5-8. 10.1186/1865-1380-5-8.
41. Kazemi A, Harvey M, Cave G, Lahner D. The effect of a lipid emulsion on depth of anaesthesia following thiopental administration to rabbits. Anaesthesia 2011, 66:373-378. 10.1111/j.1365-2044.2011.06690.x, 21418046.
42. Perichon D, Turfus S, Gerostamoulos D, Graudins A. An assessment of the in vivo effects of intravenous lipid emulsion on blood drug concentration and haemodynamics following oro-gastric amitriptyline overdose. Clin Toxicol 2013, 51:208-215. 10.3109/15563650.2013.778994.
43. Harvey M, Cave G, Shaw T. Effect of intravenous lipid emulsion and octreotide on enteric thiopentone absorption: a pilot study. Clin Toxicol 2013, 51:117-118. 10.3109/15563650.2013.766748.
44. Dunn C, Bird S, Gaspari R. Intralipid fat emulsion decreases respiratory failure in a rat model of parathion exposure. Acad Emerg Med 2012, 19:504-509. 10.1111/j.1553-2712.2012.01337.x, 22594353.
45. Fettiplace M, Ripper R, Lis K, Lin B, Lang J, Zider B, Wang J, Rubinstein I, Weinberg G. Rapid cardiotonic effects of lipid emulsion infusion. Crit Care Med 2013, 41:156-162. 10.1097/CCM.0b013e318287f874.
46. Stehr S, Ziegeler J, Pexa A, Oertel R, Deussen A, Koch T, Hübler M. The effects of lipid infusion on myocardial function and bioenergetics in l-bupivacaine toxicity in the isolated rat heart. Anesth Analg 2007, 104:186-192. 10.1213/01.ane.0000248220.01320.58, 17179268.
47. Fettiplace M, Akpa B, Ripper R, Zider B, Lang J, Rubinstein I, Weinberg G. Resuscitation with lipid emulsion: dose-dependent recovery from cardiac pharmacotoxicity requires a cardiotonic effect. Anesthesiology 2014, 120:915-925. 10.1097/ALN.0000000000000142, 24496123.
48. Partownavid P, Umar S, Li J, Rahman S, Eghbali M. Fatty-acid oxidation and calcium homeostasis are involved in the rescue of bupivacaine induced cardiotoxicity by lipid emulsion in rats. Crit Care Med 2012, 40:2431-2437. 10.1097/CCM.0b013e3182544f48, 22647409.
49. Bania T, Chu J, Lyon T, Yoon J. The role of cardiac free fatty acid metabolism in verapamil toxicity treated with intravenous fat emulsions. Acad Emerg Med 2007, 14:196-197. 10.1197/j.aem.2007.03.1268.
50. Huang J, Xian H, Bacaner M. Long chain fatty acids activate calcium channels in ventricular myocytes. Proc Natl Acad Sci U S A 1992, 89:6452-6456. 10.1073/pnas.89.14.6452, 1321440.
51. Mottram A, Valdivia C, Makielski J. Fatty acids antagonize bupivacaine induced I (NA) blockade. Clin Toxicol 2011, 49:729-733. 10.3109/15563650.2011.613399.
52. Nadrowitz F, Stoetzer C, Foadi N, Ahrens J, Wegner F, Lampert A, Koppert W, de la Roche J, Leffler A. The distinct effects of lipid emulsions used for lipid resuscitation on gating and bupivacaine induced inhibition of the cardiac sodium channel Nav1.5. Anesth Analg 2013, 117:1101-1108. 10.1213/ANE.0b013e3182a1af78, 24029851.
53. Taftachi F, Sanaei-Zadeh H, Sepehrian B, Zamani N. Lipid emulsion improves Glasgow coma scale and decreases blood glucose level in the setting of acute non-local anesthetic drug poisoning - a randomised controlled trial. Eur Rev Med Pharmacol Sci 2012, 16:38-42. 22582483.
54. Gil H, Park J, Park S, Hong S. Effect of intravenous lipid emulsion in patients with acute glyphosate intoxication. Clin Toxicol 2013, 51:767-771. 10.3109/15563650.2013.821129.
55. Cave G, Harvey M, Willer J, Uncles D, Meek T, Picard J, Weinberg G. LIPAEMIC Report: results of clinical use of intravenous lipid emulsion in drug toxicity reported to an online lipid registry. J Med Toxicol 2014, 10:133-142. 10.1007/s13181-013-0375-y, 24414252.
56. Geib A, Liebelt E, Manini A. Clinical experience with intravenous lipid emulsion for drug induced cardiovascular collapse. J Med Toxicol 2012, 8:10-14. 10.1007/s13181-011-0187-x, 21989640.
57. Hurley W, Hanlon P. Lipid emulsion as antidote at the Washington Poisons Centre: use in carbamazepine, flecainide, hydroxycholorquine, bupivacaine and bupropion. Clin Toxicol 2009, 47:729-730.
58. Kapadia K, Al Duaj N, Ganetsky M, Burke L, Horn E, Rosen C. Case series of severe TCA toxicity treated with intravenous fat emulsion. Clin Toxicol 2010, 48:612.
59. Jovic-Stosic J, Putic V, Djordjevic S, Vukcevic N, Vucinic S, Ercegovic G. Lipid emulsion in treatment of cardiovascular collapse in acute poisoning. Clin Toxicol 2013, 51:288.
60. Weinberg G, Rubinstein I. Pig in a poke: species specificity in modelling lipid resuscitation. Anesth Analg 2012, 114:907-909. 10.1213/ANE.0b013e318240d8e7, 22190553.
61. Hiller D, Gregorio G, Ripper R, Kelly K, Massad M, Edelman L, Edelman G, Feinstein DL, Weinberg GL. Epinephrine impairs lipid resuscitation from bupivacaine overdose: a threshold effect. Anesthesiology 2009, 111:498-505. 10.1097/ALN.0b013e3181afde0a, 19704251.
62. Weinberg G, Di Gregorio G, Ripper R, Kelly K, Massad M, Edelman L, Schwartz D, Shah N, Zheng S, Feinstein DL. Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose. Anesthesiology 2008, 108:907-913. 10.1097/ALN.0b013e31816d91d2, 18431127.
63. Di Gregorio G, Schwartz D, Ripper R, Kelly K, Feinstein DL, Minshall RD, Massad M, Ori C, Weinberg GL. Lipid emulsion is superior to vasopressin in a rodent model of resuscitation from toxin induced cardiac arrest. Crit Care Med 2009, 37:993-999. 10.1097/CCM.0b013e3181961a12, 19237909.
64. Mayr V, Mitterschiffhaler L, Neurater A, Gritsch C, Wenzel V, Müller T, Luckner G, Lindner KH, Strohmenger HU. A comparison of the combination of epinephrine and vasopressin with lipid emulsion in a porcine model of asphyxial cardiac arrest after intravenous injection of bupivacaine. Anesth Analg 2008, 106:1566-1571. 10.1213/01.ane.0000278866.01963.79, 18420878.
65. Mauch J, Martin J, Spielmann N, Bettschart-Wolfensberger R, Weiss M. Comparison of epinephrine vs lipid rescue to treat severe local anesthetic toxicity - an experimental study in piglets. Paediatr Anaesth 2011, 21:1103-1108. 10.1111/j.1460-9592.2011.03652.x, 21762400.
66. Bucklin M, Gordodetsky R, Wiegand T. Prolonged lipemia and pancreatitis due to extended infusion of lipid emulsion in bupropion overdose. Clin Toxicol 2013, 51:896-898. 10.3109/15563650.2013.831436.
67. Dmieski G. A commentary on the effect of lipid emulsions on pathology testing. Anaesthesioa 2009, 64:1033-1036. 10.1111/j.1365-2044.2009.06049_1.x.
68. Hiller D, Di Gregorio G, Kelly K, Ripper R, Edelman L, Boumendjel R, Drasner K, Weinberg GL. Safety of high volume lipid emulsion: a first approximation of LD50 in rats. Reg Anesth Pain Med 2010, 35:140-144. 10.1097/AAP.0b013e3181c6f5aa, 20301820.
69. Agarwala R, Ahmed S, Weigand T. Prolonged use of intravenous lipid emulsion in a severe tricyclic antidepressant overdose. J Med Toxicol 2014, 10:210-214. 10.1007/s13181-013-0353-4, 24173885.
70. Howell B, Chauhan A. A physiologically based pharmacokinetic (PBPK) model for predicting the efficacy of drug overdose treatment with liposomes in man. J Pharm Sci 2010, 99:3601-3619. 10.1002/jps.22115, 20213834.
71. Forster V, Luciani P, Leroux J. Treatment of calcium channel blocker induced cardiovascular toxicity with drug scavenging liposomes. Biomaterials 2012, 33:3578-3585. 10.1016/j.biomaterials.2012.01.042, 22330848.