Rapid cardiotonic effects of lipid emulsion infusion

Critical Care Medicine

Volumn 41, Issue 8, 2013, Pages

  Fettiplace, Michael R ^a,b   Ripper, Richard ^a,b   Lis, Kinga ^c   Lin, Bocheng ^c   Lang, Jason ^a   Zider, Brian ^a   Wang, Jing ^c   Rubinstein, Israel ^a,b   Weinberg, Guy ^a,b  

^a UNIVERSITY OF ILLINOIS   (United States)

^b JESSE BROWN VA MEDICAL CENTER   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Bupivacaine; Cardiotonic agents; Inotropic agents; Intralipid; Intravenous; Laboratory; Lipid emulsions; Lusitropy; Positive cardiac; Rats

Indexed keywords

CARDIOTONIC AGENT; INTRALIPID; SOYBEAN OIL EMULSION;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA FLOW; ARTERIAL PRESSURE; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG OVERDOSE; HEART LEFT VENTRICLE PRESSURE; INOTROPISM; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY;

ANIMALS; AORTA, ABDOMINAL; BLOOD FLOW VELOCITY; BLOOD PRESSURE; EMULSIONS; FAT EMULSIONS, INTRAVENOUS; HEART RATE; MALE; MODELS, ANIMAL; OXYGEN CONSUMPTION; PHOSPHOLIPIDS; PROSPECTIVE STUDIES; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REGIONAL BLOOD FLOW; SOYBEAN OIL; VASCULAR RESISTANCE;

EID: 84880961388     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318287f874     Document Type: Article

References (55)

1. Shipp JC, Opie LH, Challoner D: Fatty acid and glucose metabolism in the perfused heart. Nature 1961; 189:1018-1019
2. Van de Velde M, Wouters PF, Rolf N, et al: Long-chain triglycerides improve recovery from myocardial stunning in conscious dogs. Cardiovasc Res 1996; 32:1008-1015
3. Rahman S, Li J, Bopassa JC, et al: Phosphorylation of GSK-3β mediates intralipid-induced cardioprotection against ischemia/reperfusion injury. Anesthesiology 2011; 115:242-253
4. Riquelme CA, Magida JA, Harrison BC, et al: Fatty acids identified in the Burmese python promote beneficial cardiac growth. Science 2011; 334:528-531
5. Weinberg G, Ripper R, Feinstein DL, et al: Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anesth Pain Med 2003; 28:198-202
6. Sirianni AJ, Osterhoudt KC, Calello DP, et al: Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine. Ann Emerg Med 2008; 51:412-415
7. Weinberg G, Di Gregorio G, Hiller D, et al: Reversal of haloperidolinduced cardiac arrest by using lipid emulsion. Ann Intern Med 2009; 150:737-738
8. Young AC, Velez LI, Kleinschmidt KC: Intravenous fat emulsion therapy for intentional sustained-release verapamil overdose. Resuscitation 2009; 80:591-593
9. Jakkala-Saibaba R, Morgan PG, Morton GL: Treatment of cocaine overdose with lipid emulsion. Anaesthesia 2011; 66:1168-1170
10. Weinberg GL: Lipid emulsion infusion: Resuscitation for local anesthetic and other drug overdose. Anesthesiology 2012; 117:180-187
11. Rotenberg M, Rubin M, Bor A, et al: Physico-chemical characterization of intralipid emulsions. Biochim Biophys Acta 1991; 1086:265-272
12. Cook DJ, Housmans PR: Mechanism of the negative inotropic effect of propofol in isolated ferret ventricular myocardium. Anesthesiology 1994; 80:859-871
13. Ririe DG, Lundell JC, Neville MJ: Direct effects of propofol on myocardial and vascular tissue from mature and immature rats. J Cardiothorac Vasc Anesth 2001; 15:745-749
14. Grimes JB, Abel RM: Acute hemodynamic effects of intravenous fat emulsion in dogs. JPEN J Parenter Enteral Nutr 1979; 3:40-44
15. Ackerman L, Freeman ML, Pacold I, et al: Effect of acute postinfusion lipemia and free fatty acids on myocardial contractility: Assessment with radionuclide ventriculography. Eur J Nucl Med 1986; 12:201-204
16. Pacold I, Ackerman L, Johnson B, et al: The effects of acute hypertriglyceridemia and high levels of free fatty acids on left ventricular function. Am Heart J 1985; 110:836-840
17. Kjekshus JK, Mjos OD: Effect of free fatty acids on myocardial function and metabolism in the ischemic dog heart. J Clin Invest 1972; 51:1767-1776
18. Yang CY, Wong CS, Yu CC, et al: Propofol inhibits cardiac L-type calcium current in guinea pig ventricular myocytes. Anesthesiology 1996; 84:626-635
19. Sprung J, Ogletree-Hughes ML, McConnell BK, et al: The effects of propofol on the contractility of failing and nonfailing human heart muscles. Anesth Analg 2001; 93:550-559
20. Fisch D, Abel RM: Hemodynamic effects of intravenous fat emulsions in patients with heart disease. JPEN J Parenter Enteral Nutr 1981; 5:402-405
21. Azuma M, Matsumura C, Kemmotsu O: Inotropic and electrophysiologic effects of propofol and thiamylal in isolated papillary muscles of the guinea pig and the rat. Anesth Analg 1993; 77:557-563
22. Atik M, Marrero R, Isla F, et al: Hemodynamic changes following infusion of intravenous fat emulsions. Am J Clin Nutr 1965; 16:68-74
23. Mitchell LA, Grant DF, Melchert RB, et al: Linoleic acid metabolites act to increase contractility in isolated rat heart. Cardiovasc Toxicol 2002; 2:219-230
24. Haim TE, Wang W, Flagg TP, et al: Palmitate attenuates myocardial contractility through augmentation of repolarizing Kv currents. J Mol Cell Cardiol 2010; 48:395-405
25. Grimsgaard S, Bonaa KH, Jacobsen BK, et al: Plasma saturated and linoleic fatty acids are independently associated with blood pressure. Hypertension 1999; 34:478-483
26. Holland DJ, Erne D, Kostner K, et al: Acute elevation of triglycerides increases left ventricular contractility and alters ventricular-vascular interaction. Am J Physiol Heart Circ Physiol 2011; 301:H123-H128
27. Umpierrez GE, Smiley D, Robalino G, et al: Intravenous intralipidinduced blood pressure elevation and endothelial dysfunction in obese African-Americans with type 2 diabetes. J Clin Endocrinol Metab 2009; 94:609-614
28. Siqueira J, Smiley D, Newton C, et al: Substitution of standard soybean oil with olive oil-based lipid emulsion in parenteral nutrition: Comparison of vascular, metabolic, and inflammatory effects. J Clin Endocrinol Metab 2011; 96:3207-3216
29. U.S. Department of Health and Human Services: Food and Drug Administration Center for Drug Evaluation and Research (CDER)-Guidance for Industry Estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteer. Available at: http://fdadrugs. legalview.com/legal-issue/allay/fda-alerts/guidance-for-industry-estimating-the- maximum-safe-starting-dose-inini/449452/. Accessed September 27, 2012
30. Jessup M, Brozena S: Heart failure. N Engl J Med 2003; 348:2007-2018
31. Cohn JN, Johnson G, Ziesche S, et al: A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N Engl J Med 1991; 325:303-310
32. Philbin EF, Rocco TA Jr, Lindenmuth NW, et al: Systolic versus diastolic heart failure in community practice: Clinical features, outcomes, and the use of angiotensin-converting enzyme inhibitors. Am J Med 2000; 109:605-613
33. Partownavid P, Umar S, Li J, et al: Fatty-acid oxidation and calcium homeostasis are involved in the rescue of bupivacaine-induced cardiotoxicity by lipid emulsion in rats. Crit Care Med 2012; 40:2431-2437
34. Liu L, Xia Y, Chen Y, et al: The comparative effects of lipid, epinephrine, and their combination in the reversal of bupivacaine-induced asystole in the isolated rat heart. Anesth Analg 2012; 114:886-893
35. Hiller DB, Gregorio GD, Ripper R, et al: Epinephrine impairs lipid resuscitation from bupivacaine overdose: A threshold effect. Anesthesiology 2009; 111:498-505
36. Weinberg GL, Di Gregorio G, Ripper R, et al: Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose. Anesthesiology 2008; 108:907-913
37. Stehr SN, Ziegeler JC, Pexa A, et al: The effects of lipid infusion on myocardial function and bioenergetics in l-bupivacaine toxicity in the isolated rat heart. Anesth Analg 2007; 104:186-192
38. Li J, Iorga A, Sharma S, et al: Intralipid, a clinically safe compound, protects the heart against ischemia-reperfusion injury more efficiently than cyclosporine-A. Anesthesiology 2012; 117:836-846
39. Hu ZY, Luo NF, Liu J: The protective effects of emulsified isoflurane on myocardial ischemia and reperfusion injury in rats. Can J Anaesth 2009; 56:115-125
40. Ko SH, Yu CW, Lee SK, et al: Propofol attenuates ischemiareperfusion injury in the isolated rat heart. Anesth Analg 1997; 85:719-724
41. Ebel D, Schlack W, Comfère T, et al: Effect of propofol on reperfusion injury after regional ischaemia in the isolated rat heart. Br J Anaesth 1999; 83:903-908
42. Chan DL, Freeman LM, Rozanski EA, et al: Colloid osmotic pressure of parenteral nutrition components and intravenous fluids. J Vet Emerg Crit Car 2001; 11:269-273
43. Stepniakowski KT, Goodfriend TL, Egan BM: Fatty acids enhance vascular alpha-adrenergic sensitivity. Hypertension 1995; 25(4, Part 2):774-778
44. Stepniakowski KT, Sallee FR, Goodfriend TL, et al: Fatty acids enhance neurovascular reflex responses by effects on alpha 1-adrenoceptors. Am J Physiol 1996; 270(6, Part 2):R1340-R1346
45. Schümann HJ, Endoh S, Brodde OE: The time course of the effects of beta-and alpha-adrenoceptor stimulation by isoprenaline and methoxamine on the contractile force and cAMP level of the isolated rabbit papillary muscle. Naunyn Schmiedebergs Arch Pharmacol 1975; 289:291-302
46. Hausenloy DJ, Yellon DM: New directions for protecting the heart against ischaemia-reperfusion injury: Targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway. Cardiovasc Res 2004; 61:448-460
47. Yellon DM, Hausenloy DJ: Myocardial reperfusion injury. N Engl J Med 2007; 357:1121-1135
48. Yano S, Tokumitsu H, Soderling TR: Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway. Nature 1998; 396:584-587
49. Pérez-García MJ, Ceña V, de Pablo Y, et al: Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway. J Biol Chem 2004; 279:6132-6142
50. Song G, Ouyang G, Bao S: The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 2005; 9:59-71
51. Goldbart A, Cheng ZJ, Brittian KR, et al: Intermittent hypoxia induces time-dependent changes in the protein kinase B signaling pathway in the hippocampal CA1 region of the rat. Neurobiol Dis 2003; 14:440-446
52. Lebeche D, Davidoff AJ, Hajjar RJ: Interplay between impaired calcium regulation and insulin signaling abnormalities in diabetic cardiomyopathy. Nat Clin Pract Cardiovasc Med 2008; 5:715-724
53. Latronico MV, Costinean S, Lavitrano ML, et al: Regulation of cell size and contractile function by AKT in cardiomyocytes. Ann N Y Acad Sci 2004; 1015:250-260
54. Litonius E, Tarkkila P, Neuvonen PJ, et al: Effect of intravenous lipid emulsion on bupivacaine plasma concentration in humans. Anaesthesia 2012; 67:600-605
55. Mottram AR, Valdivia CR, Makielski JC: Fatty acids antagonize bupivacaine-induced I(Na) blockade. Clin Toxicol (Phila) 2011; 49:729-733