Lipid Infusion Accelerates Removal of Bupivacaine and Recovery From Bupivacaine Toxicity in the Isolated Rat Heart

Regional Anesthesia and Pain Medicine

Volumn 31, Issue 4, 2006, Pages 296-303

  Weinberg, Guy L ^a,b   Ripper, Richard ^a,b   Murphy, Patricia ^a,b   Edelman, Lucas B ^a   Hoffman, William ^a   Strichartz, Gary ^c   Feinstein, Douglas L ^a,b  

^a UNIVERSITY OF ILLINOIS   (United States)

^b JESSE BROWN VA MEDICAL CENTER   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Bupivacaine; Cardiac toxicity; Lipid emulsion; Lipid rescue; Local anesthetic

Indexed keywords

BUPIVACAINE; INTRALIPID; LIPID EMULSION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASYSTOLE; BIOPSY; CARDIOTOXICITY; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; HEART BEAT; HEART CONTRACTION; HEART FUNCTION; HEART LEFT VENTRICLE CONTRACTION; HEART RATE; ISOLATED HEART; ISOTOPE LABELING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE;

ANALYSIS OF VARIANCE; ANESTHETICS, LOCAL; ANIMALS; BIOPSY; BLOOD PRESSURE; BUPIVACAINE; FAT EMULSIONS, INTRAVENOUS; HEART; HEART RATE; INFUSIONS, INTRAVENOUS; MALE; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 33745941830     PISSN: 10987339     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rapm.2005.02.011     Document Type: Article

References (28)

1. Levsky M.E., and Miller M.A. Cardiovascular collapse from low dose bupivacaine. Can J Clin Pharmacol 12 (2005) e240-e245
2. Salomaki T.E., Laurila P.A., and Ville J. Successful resuscitation after cardiovascular collapse following accidental intravenous infusion of levobupivacaine during general anesthesia. Anesthesiology 103 (2005) 1095-1096
3. Mather L.E., Copeland S.E., and Ladd L.A. Acute toxicity of local anesthetics. underlying pharmacokinetic and pharmacodynamic concepts. Reg Anesth Pain Med 30 (2005) 553-566
4. Heavner J.E. Cardiac toxicity of local anesthetics in the intact isolated heart model. A review. Reg Anesth Pain Med 27 (2002) 545-555
5. Bozkurt P., Arslan I., Bakan M., and Cansever M.S. Free plasma levels of bupivacaine and ropivacaine when used for caudal block in children. Eur J Anaesthesiol 22 (2005) 640-641
6. Chang D.H., Ladd L.A., Copeland S., Iglesias M.A., Plummer J.L., and Mather L.E. Direct cardiac effects of intracoronary bupivacaine, levobupivacaine and ropivacaine in the sheep. Br J Pharmacol 132 (2001) 649-658
7. Lefrant J.Y., de La Coussaye J.E., Ripart J., Muller L., Lalourcey L., Peray P.A., Mazoit X., Sassine A., and Eledjam J.J. The comparative electrophysiologic and hemodynamic effects of a large dose of ropivacaine and bupivacaine in anesthetized and ventilated piglets. Anesth Analg 93 (2001) 1598-1605
8. Rosen M.A., Thigpen J.W., Shnider S.M., Foutz S.E., Levinson G., and Koike M. Bupivacaine-induced cardiotoxicity in hypoxic and acidotic sheep. Anesth Analg 64 (1985) 1089-1096
9. Butterworth J.F.T., Brownlow R.C., Leith J.P., Prielipp R.C., and Cole L.R. Bupivacaine inhibits cyclic-3′,5′-adenosine monophosphate production. A possible contributing factor to cardiovascular toxicity. Anesthesiology 79 (1993) 88-95
10. Clarkson C.W., and Hondeghem L.M. Mechanism for bupivacaine depression of cardiac conduction. Fast block of sodium channels during the action potential with slow recovery from block during diastole. Anesthesiology 62 (1985) 396-405
11. Sztark F., Malgat M., Dabadie P., and Mazat J.P. Comparison of the effects of bupivacaine and ropivacaine on heart cell mitochondrial bioenergetics. Anesthesiology 88 (1998) 1340-1349
12. Lynch III C. Depression of myocardial contractility in vitro by bupivacaine, etidocaine, and lidocaine. Anesth Analg 65 (1986) 551-559
13. Groban L., Deal D.D., Vernon J.C., James R.L., and Butterworth J. Cardiac resuscitation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine, and ropivacaine in anesthetized dogs. Anesth Analg 92 (2001) 37-43
14. Heavner J.E., Pitkanen M.T., Shi B., and Rosenberg P.H. Resuscitation from bupivacaine-induced asystole in rats. Comparison of different cardioactive drugs. Anesth Analg 80 (1995) 1134-1139
15. Ohmura S., Kawada M., Ohta T., Yamamoto K., and Kobayashi T. Systemic toxicity and resuscitation in bupivacaine-, levobupivacaine-, or ropivacaine-infused rats. Anesth Analg 93 (2001) 743-748
16. Groban L., and Butterworth J. Lipid reversal of bupivacaine toxicity. Has the silver bullet been identified?. Reg Anesth Pain Med 28 (2003) 167-169
17. Weinberg G.L., VadeBoncouer T., Ramaraju G.A., Garcia-Amaro M.F., and Cwik M.J. Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology 88 (1998) 1071-1075
18. Weinberg G., Ripper R., Feinstein D.L., and Hoffman W. Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anesth Pain Med 28 (2003) 198-202
19. Weinberg G.L., Palmer J.W., VadeBoncouer T.R., Zuechner M.B., Edelman G., and Hoppel C.L. Bupivacaine inhibits acylcarnitine exchange in cardiac mitochondria. Anesthesiology 92 (2000) 523-528
20. Timour Q., Freysz M., Lang J., Beal J.L., Lakhal M., Bertrix L., and Faucon G. Electrophysiological study in the dog of the risk of cardiac toxicity of bupivacaine. Arch Int Pharmacodyn Ther 287 (1987) 65-77
21. Mazoit J.X., Orhant E.E., Boico O., Kantelip J.P., and Samii K. Myocardial uptake of bupivacaine: I. Pharmacokinetics and pharmacodynamics of lidocaine and bupivacaine in the isolated perfused rabbit heart. Anesth Analg 77 (1993) 469-476
22. Tune J.D., Richmond K.N., Gorman M.W., and Feigl E.O. Control of coronary blood flow during exercise. Exp Biol Med (Maywood) 227 (2002) 238-250
23. Englesson S. The influence of acid-base changes on central nervous system toxicity of local anaesthetic agents. I. An experimental study in cats. Acta Anaesthesiol Scand 18 (1974) 79-87
24. Cho H.S., Lee J.J., Chung I.S., Shin B.S., Kim J.A., and Lee K.H. Insulin reverses bupivacaine-induced cardiac depression in dogs. Anesth Analg 91 (2000) 1096-1102
25. Kim J.T., Jung C.W., and Lee K.H. The effect of insulin on the resuscitation of bupivacaine-induced severe cardiovascular toxicity in dogs. Anesth Analg 99 (2004) 728-733
26. Weinberg G., and VadeBoncouer T. Improved energetics may explain the favorable effect of insulin infusion on bupivacaine cardiotoxicity. Anesth Analg 92 (2001) 1075-1076
27. Varshney M., Morey T.E., Shah D.O., Flint J.A., Moudgil B.M., Seubert C.N., and Dennis D.M. Pluronic microemulsions as nanoreservoirs for extraction of bupivacaine from normal saline. J Am Chem Soc 126 (2004) 5108-5112
28. Renehan E.M., Enneking F.K., Varshney M., Partch R., Dennis D.M., and Morey T.E. Scavenging nanoparticles. an emerging treatment for local anesthetic toxicity. Reg Anesth Pain Med 30 (2005) 380-384