Serum verapamil concentrations before and after Intralipid ® therapy during treatment of an overdose

Clinical Toxicology

Volumn 49, Issue 4, 2011, Pages 340-344

  French, Deborah ^a   Armenian, Patil ^b   Ruan, Weiming ^b   Wong, Alicia ^b   Drasner, Kenneth ^b   Olson, Kent R ^b   Wu, Alan H B ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Calcium channel blocker; Hyperinsulinemia euglycemia therapy; Lipid emulsion therapy

Indexed keywords

ADRENALIN; ATROPINE; CALCIUM; DOPAMINE; GLUCAGON; GLUCONATE CALCIUM; INSULIN; INTRALIPID; NORADRENALIN; PHENYLEPHRINE; TRIACYLGLYCEROL; VASOPRESSIN; VERAPAMIL;

ADULT; ARTICLE; CASE REPORT; COMPLETE HEART BLOCK; DRUG CONCENTRATION; DRUG DOSE TITRATION; DRUG EFFECT; DRUG OVERDOSE; EMERGENCY CARE; ENDOTRACHEAL INTUBATION; HUMAN; HYPERINSULINEMIA; HYPOTENSION; HYPOXIA; LETHARGY; MALE; PLEURA EFFUSION; SUSTAINED DRUG RELEASE; THORACOCENTESIS; TUBE;

CALCIUM CHANNEL BLOCKERS; EMULSIONS; FAT EMULSIONS, INTRAVENOUS; HUMANS; MALE; MIDDLE AGED; OVERDOSE; PHOSPHOLIPIDS; SOYBEAN OIL; TRIGLYCERIDES; VERAPAMIL;

EID: 79956064808     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.3109/15563650.2011.572556     Document Type: Article

References (20)

1. Ludot H, Tharin JY, Belouadah M, Mazoit JX, Malinovsky JM. Successful resuscitation after ropivacaine and lidocaine-induced ventricular arrhythmia following posterior lumbar plexus block in a child. Anesth Analg 2008; 106:1572-1574. (Pubitemid 351571095)
2. Litz RJ, Roessel T, Heller AR, Stehr SN. Reversal of central nervous system and cardiac toxicity after local anesthetic intoxication by lipid emulsion injection. Anesth Analg 2008; 106:1575-1577. (Pubitemid 351571096)
3. Warren JA, Thoma RB, Georgescu A, Shah SJ. Intravenous lipid infusion in the successful resuscitation of local anesthetic-induced cardiovascular collapse after supraclavicular brachial plexus block. Anesth Analg 2008; 106:1578-1580. (Pubitemid 351571097)
4. Smith HM, Jacob AK, Segura LG, Dilger JA, Torsher LC. Simulation education in anesthesia training: a case report of successful resuscitation of bupivacaine-induced cardiac arrest linked to recent simulation training. Anesth Analg 2008; 106:1581-1584. (Pubitemid 351571098)
5. Weinberg GL, VadeBoncouer T, Ramaraju GA, Garcia-Amaro MF, Cwik MJ. Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology 1998; 88:1071-1075. (Pubitemid 28193335)
6. Weinberg GL, Ripper R, Feinstein DL, Hoffman W. Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anesth Pain Med 2003; 28:198-202. (Pubitemid 36618312)
7. Tebbutt S, Harvey M, Nicholson T, Cave G. Intralipid prolongs survival in a rat model of verapamil toxicity. Acad Emerg Med 2006; 13:134-139. (Pubitemid 43155818)
8. Mazoit J, Le Guen R, Beloeil H, Benhamou D. Binding of longlasting local anesthetics to lipid emulsions. Anesthesiology 2009; 110:380-386.
9. Sirianni AJ, Osterhoudt KC, Calello DP, Muller AA, Waterhouse MR, Goodkin MB et al. Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine. Ann Emerg Med 2008; 51:412-415.
10. Finn S, Uncles D, Willers J, Sable N. Early treatment of a quetiapine and sertraline overdose with Intralipid. Anesthesia 2009; 64:191-194.
11. Dolcourt BA, Aaron CK. Intravenous fat emulsion for refractory verapamil and atenolol induced shock: a human case report [abstract]. Clin Toxicol 2008; 46:619-620.
12. Young AC, Velez LI, Kleinschmidt KC. Intravenous fat emulsion therapy for intentional sustained-release verapamil overdose. Resuscitation 2009; 80:591-593.
13. Kerns W. Management of b-adrenergic blocker and calcium channel antagonist toxicity. Emerg Med Clin North Am 2007; 25:309-331.
14. Bronstein AC, Spyker DA, Cantilena LR, Green JL, Rumack BH, Giffin SL. 2009 annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 27th annual report. Clin Toxicol 2010; 48:979-1178.
15. Association of Anesthetists of Great Britain and Ireland. Guidelines for the management of severe local anaesthetic toxicity. .
16. Neal JM, Bernards CM, Butterworth JF, Gregorio GD, Drasner K, Hejtmanek MR et al. ASRA practice advisory on local anesthetic systemic toxicity. Reg Anesth Pain Med 2010; 35:152-161.
17. Barrow PM, Houston PL, Wong DT. Overdose of sustained-release verapamil. Br J Anaesth 1994, 72: 361-365. (Pubitemid 24089753)
18. Bania TC, Chu J, Perez E, Su M, Hahn IH. Hemodynamic effects of intravenous fat emulsion in an animal model of severe verapamil toxicity resuscitated with atropine, calcium and saline. Acad Emerg Med 2007; 14:105-111. (Pubitemid 46157192)
19. Van de Velde M, Wouters PF, Rolf N, Van Aken H, Flameng W, Vandermeersch E. Long-chain triglycerides improve recovery from myocardial stunning in conscious dogs. Cardiovasc Res 1996; 32:1008-1015. (Pubitemid 26423389)
20. The PubChem Database. http://pubchem.ncbi.nlm.nih.gov/. Accessed 4 November 2010.