Intravenous lipid emulsion entraps amitriptyline into plasma and can lower its brain concentration - an experimental intoxication study in pigs

Basic and Clinical Pharmacology and Toxicology

Volumn 113, Issue 3, 2013, Pages 193-200

  Heinonen, Juho A ^a   Litonius, Erik ^b   Backman, Janne T ^a   Neuvonen, Pertti J ^a   Rosenberg, Per H ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; LIPID EMULSION;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTRAL VENOUS PRESSURE; CIRCULATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG TISSUE LEVEL; EXPERIMENTAL PIG; EXPERIMENTAL STUDY; FEMALE; FRONTAL CORTEX; HEART RATE; HEMODYNAMICS; HYPOTENSION; INTOXICATION; MALE; MEAN ARTERIAL PRESSURE; MEASUREMENT; NONHUMAN; PLASMA HALF LIFE; PRESSURE MEASUREMENT; PRIORITY JOURNAL; TISSUE DISTRIBUTION; VENOUS BLOOD;

AMITRIPTYLINE; ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; DRUG OVERDOSE; FAT EMULSIONS, INTRAVENOUS; HEMODYNAMICS; RANDOM ALLOCATION; SWINE;

SUIDAE;

EID: 84880697855     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/bcpt.12082     Document Type: Article

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