Fatty acids antagonize bupivacaine - Induced INa blockade

Clinical Toxicology

Volumn 49, Issue 8, 2011, Pages 729-733

  Mottram, Allan R ^a   Valdivia, Carmen R ^a   Makielski, Jonathan C ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Cardiac support; Cardiovascular; Heart

Indexed keywords

BUPIVACAINE; LINOLENIC ACID; LIPID EMULSION; POLYUNSATURATED FATTY ACID; SATURATED FATTY ACID; STEARIC ACID; VOLTAGE GATED SODIUM CHANNEL;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; SODIUM CURRENT; VOLTAGE CLAMP;

ALPHA-LINOLENIC ACID; ANESTHETICS, LOCAL; BUPIVACAINE; CARDIAC ELECTROPHYSIOLOGY; FAT EMULSIONS, INTRAVENOUS; HEART; HEK293 CELLS; HUMANS; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; STEARIC ACIDS; TRANSFECTION;

EID: 80053626003     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.3109/15563650.2011.613399     Document Type: Article

References (21)

1. Eledjam JJ, de la Coussaye JE, Brugada J, Bassoul B, Gagnol JP, Fabregat JR, Massé C, Sassine A. In vitro study on mechanisms of bupivacaine-induced depression of myocardial contractility. Anesth Analg 1989; 69:732-735. (Pubitemid 20041775)
2. Butterworth JF, Brownlow RC, Leith JP, Prielipp RC, Cole LR. Bupivacaine inhibits cyclic-3 ' ,5 ' -adenosine monophosphate production. A possible contributing factor to cardiovascular toxicity. Anesthesiology 1993; 79:88-95. (Pubitemid 23215153)
3. Weinberg GL, Palmer JW, VadeBoncouer TR, Zuechner MB, Edelman G, Hoppel CL. Bupivacaine inhibits acylcarnitine exchange in cardiac mitochondria. Anesthesiology 2000; 92:523-528. (Pubitemid 30078352)
4. Scholz A. Mechanisms of (local) anaesthetics on voltage-gated sodium and other ion channels. Br J Anaesth 2002; 89:52-61. (Pubitemid 34778103)
5. Cordell CL, Schubkegel T, Light TR, Ahmad F. Lipid infusion rescue for bupivacaine-induced cardiac arrest after axillary block. J Hand Surg Am 2010; 35:144-146.
6. Holm T, Andreassen AK, Aukrust P, Andersen K, Geiran OR, Kjekshus J, Simonsen S, Gullestad L. Omega-3 fatty acids improve blood pressure control and preserve renal function in hypertensive heart transplant recipients. Eur Heart J 2001; 22:428-436. (Pubitemid 32622448)
7. Rosenblatt MA, Abel M, Fischer GW, Itzkovich CJ, Eisenkraft JB. Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology 2006; 105:217-218. (Pubitemid 44305211)
8. Smith H, Jacob A, Segura L, Dilger JA, Torsher L. Simulation education in anesthesia training: A case report of successful resuscitation of bupivacaine-induced cardiac arrest linked to recent simulation training. Anesthesia and Analgesia 2008; 106:1581-1584, table of contents. (Pubitemid 351571098)
9. Weinberg G, Ripper R, Feinstein DL, Hoffman W. Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Regional Anesthesia and Pain Medicine 2003; 28:198-202. (Pubitemid 36618312)
10. Weinberg GL, VadeBoncouer T, Ramaraju GA, Garcia-Amaro MF, Cwik MJ. Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology 1998; 88:1071-1075. (Pubitemid 28193335)
11. Jamaty C, Bailey B, Larocque A, Notebaert E, Sanogo K, Chauny JM. Lipid emulsions in the treatment of acute poisoning: A systematic review of human and animal studies. Clin toxicol (Philadelphia, Pa) 2010; 48:1-27.
12. Turner-Lawrence D, Kerns W. Intravenous Fat Emulsion: A Potential Novel Antidote. Toxicol Rev 2008; 4:108-114.
13. Leaf A, Kang JX, Xiao YF. Fish oil fatty acids as cardiovascular drugs. Curr Vasc Pharmacol 2008; 6:1-12.
14. Xiao YF, Wright SN, Wang GK, Morgan JP, Leaf A. Coexpression with beta(1)-subunit modifi es the kinetics and fatty acid block of hH1(alpha) Na(+) channels. Am J Physiol Heart Circ Physiol 2000; 279:H35-H46. (Pubitemid 30616645)
15. Groban L, Deal DD, Vernon JC, James RL, Butterworth J. Cardiac resuscitation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine, and ropivacaine in anesthetized dogs. Anesth Analg 2001; 92:37-43. (Pubitemid 32039174)
16. Xiao Y, Sigg D, Leaf A. The Antiarrhythmic Effect of n-3 Polyunsaturated Fatty Acids: Modulation of Cardiac Ion Channels as a Potential Mechanism. J Membrane Biol 2005; 206:141-154. (Pubitemid 43199147)
17. Li GR, Sun HY, Zhang XH, Cheng LC, Chiu SW, Tse HF, Lau CP. Omega-3 polyunsaturated fatty acids inhibit transient outward and ultra-rapid delayed rectifi er K+ currents and Na+ current in human atrial myocytes. Cardiovasc Res 2009; 81:286-293.
18. Pepe S, Bogdanov K, Hallaq H, Spurgeon H, Leaf A, Lakatta E. Omega 3 polyunsaturated fatty acid modulates dihydropyridine effects on L-type Ca2+ channels, cytosolic Ca2+ , and contraction in adult rat cardiac myocytes. Proc Natl Acad Sci USA 1994; 91:8832-8836. (Pubitemid 2148794)
19. Xiao YF, Ke Q, Chen Y, Morgan JP, Leaf A. Inhibitory effect of n-3 fi sh oil fatty acids on cardiac Na+ /Ca2+ exchange currents in HEK293t cells. Biochemical and Biophysical Research Communications 2004; 321:116-123. (Pubitemid 39060658)
20. Richardson ES, Iaizzo PA, Xiao YF. Electrophysiological Mechanisms of the Anti-arrhythmic Effects of Omega-3 Fatty Acids. J Cardiovasc Transl Res 2011; 4:42-52.
21. Xiao YF, Ke Q, Wang SY, Auktor K, Yang Y, Wang GK, Morgan JP, Leaf A. Single point mutations affect fatty acid block of human myocardial sodium channel alpha subunit Na+ channels. Proc Natl Acad Sci USA 2001; 98:3606-3611. (Pubitemid 32220892)