The distinct effects of lipid emulsions used for "lipid resuscitation" on gating and bupivacaine-induced inhibition of the cardiac sodium channel nav1.5

Anesthesia and Analgesia

Volumn 117, Issue 5, 2013, Pages 1101-1108

  Nadrowitz, Felix ^a   Stoetzer, Carsten ^a   Foadi, Nilufar ^a   Ahrens, Jörg ^a   Wegner, Florian ^b   Lampert, Angelika ^c   Koppert, Wolfgang ^a   De La Roche, Jeanne ^a   Leffler, Andreas ^a  

^a Department of Anesthesiology and Intensive Care Medicine ^*  (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; INTRALIPID; LIPID EMULSION; LIPOFUNDIN; SODIUM CHANNEL NAV1.5; DRUG COMBINATION; EMULSION; LIPID; LOCAL ANESTHETIC AGENT; PHOSPHOLIPID; SCN5A PROTEIN, HUMAN; SODIUM CHANNEL BLOCKING AGENT; SORBITOL; SOYBEAN OIL; SOYBEAN OIL, PHOSPHOLIPID EMULSION;

ANESTHESIA COMPLICATION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRIC POTENTIAL; HUMAN; HUMAN CELL; HYPERPOLARIZATION; IC 50; KIDNEY CELL; LIPID RESUSCITATION; PATCH CLAMP; PRIORITY JOURNAL; RESUSCITATION; SODIUM CONDUCTANCE; SODIUM CURRENT; STEADY STATE; ABSORPTION; CHEMISTRY; DOSE RESPONSE; DRUG COMBINATION; DRUG EFFECTS; ELECTROPHYSIOLOGY; EMULSION; HEK293 CELL LINE; IC50; KIDNEY; PATCH CLAMP TECHNIQUE; PHARMACOLOGY;

ABSORPTION; ANESTHETICS, LOCAL; BUPIVACAINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; ELECTROPHYSIOLOGY; EMULSIONS; FAT EMULSIONS, INTRAVENOUS; HEK293 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; KIDNEY; LIPIDS; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; PATCH-CLAMP TECHNIQUES; PHOSPHOLIPIDS; SODIUM CHANNEL BLOCKERS; SORBITOL; SOYBEAN OIL;

EID: 84887110882     PISSN: 00032999     EISSN: 15267598     Source Type: Journal    
DOI: 10.1213/ANE.0b013e3182a1af78     Document Type: Article

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