Intralipid Outperforms Sodium Bicarbonate in a Rabbit Model of Clomipramine Toxicity

Annals of Emergency Medicine

Volumn 49, Issue 2, 2007, Pages

  Harvey, Martyn ^a   Cave, Grant ^b  

^a WAIKATO HOSPITAL   (New Zealand)

^b MONASH MEDICAL CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; BICARBONATE; CLOMIPRAMINE; INTRALIPID; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; FEMALE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; PULSE RATE; QRS COMPLEX; RABBIT; RESUSCITATION; SHOCK;

EID: 33846185480     PISSN: 01960644     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.annemergmed.2006.07.016     Document Type: Article

References (29)

1. Yoav G., Odelia G., and Shaltiel C. A lipid emulsion reduces mortality from clomipramine overdose in rats. [letter]. Vet Hum Toxicol 44 (2002) 30
2. Weinberg G.L., VadeBoncouer T., Ramaraju G.A., et al. Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anaesthesiology 88 (1998) 1071-1075
3. Weinberg G., Ripper R., Feinstein D.L., et al. Lipid emulsion infusion rescues dogs from bupivacaine induced cardiac toxicity. Reg Anesth Pain Med 28 (2003) 198-202
4. Dalgleish D., and Katawaroo S. Lipid emulsion to treat bupivacaine toxicity. [letter]. Anaesthesia 60 (2005) 1158
5. Picard J., and Meek T. Lipid emulsion to treat overdose of local anaesthetic: the gift of the glob. Anaesthesia 61 (2006) 107-109
6. Tebbutt S., Harvey M., Nicholson T., et al. Intralipid prolongs survival in a rat model of verapamil toxicity. Acad Emerg Med 13 (2006) 134-139
7. Cave G., Harvey M., and Castle C. Intralipid ameliorates thiopentone induced respiratory depression in rats: investigative pilot study. [letter]. Emerg Med Australas 17 (2005) 180-181
8. Cave G., Harvey M., and Castle C. The role of fat emulsion therapy in a rodent model of propranolol toxicity: a preliminary study. J Med Toxicol 2 (2006) 4-7
9. Pedersen O.L., Gram L.F., Kristensen C.B., et al. Overdosage of antidepressants: clinical and pharmacokinetic aspects. Eur J Pharmacol 23 (1982) 513-521
10. Thanacoody H.K., and Thomas S.H. Tricyclic antidepressant poisoning: cardiovascular toxicity. Toxicol Rev 24 (2005) 205-214
11. Cheeta S., Schifano F., Osefeso A., et al. Antidepressant related deaths and antidepressant prescriptions in England and Wales 1998-2000. Br J Psychiatry 184 (2004) 41-47
12. Kerr G.W., McGuffie A.C., and Wilkie S. Tricyclic antidepressant overdose: a review. Emerg Med J 18 (2001) 236-241
13. Citak A., Soysal D.D., Ucsel R., et al. Efficacy of long duration resuscitation and magnesium sulphate treatment in amitriptyline poisoning. Eur J Emerg Med 9 (2002) 63-66
14. Larkin G.L., Graeber G.M., and Hollingsed M.J. Experimental amitriptyline poisoning: treatment of severe cardiovascular toxicity with cardiopulmonary bypass. Ann Emerg Med 23 (1994) 480-486
15. McCabe J.L., Cobaugh D.J., Menegazzi J.J., et al. Experimental tricyclic antidepressant toxicity: a randomised, controlled comparison of hypertonic saline solution, sodium bicarbonate, and hyperventilation. Ann Emerg Med 32 (1998) 329-333
16. Mignini M.A., Piacentini E., and Dubin A. Peripheral arterial blood pressure monitoring adequately tracks central blood pressure in critically ill patients: an observational study. Crit Care 10 (2006) R43
17. Lee S.K., Vaagenes P., Safar P., et al. Effect of cardiac arrest time on cortical cerebral blood flow during subsequent standard external cardiopulmonary resuscitation in rabbits. Resuscitation 17 (1989) 105-117
18. Abel R.M., Fisch D., and Grossman M.L. Hemodynamic effects of intravenous 20% soy oil emulsion following coronary bypass surgery. JPEN J Parenter Enteral Nutr 7 (1983) 534-540
19. Straathof D., Driessen O., Meyer W., et al. Influence of Intralipid infusion on elimination of phenytoin. Arch Int Pharmacodyn 267 (1984) 180-186
20. Krieglstein J., Meffert A., and Niemeyer D. Influence of emulsified fat on chlorpromazine availability in rat blood. Experientia 30 (1974) 924-926
21. Minton N.A., Goode A.G., and Henry J.A. The effect of lipid suspension on amitriptyline disposition. Arch Toxicol 60 (1987) 467-469
22. Van de Velde M., Woutens P.F., Rolf N., et al. Long-chain triglycerides improve recovery from myocardial stunning in conscious dogs. Cardiovasc Res 32 (1996) 1008-1015
23. Tamm C., Benzi R., Papogeorgiou I., et al. Substrate competition in postischemic myocardium. Circ Res 75 (1994) 1103-1112
24. Le Dinh T., Treneaux E., Labbe G., et al. Amineptine, a tricyclic antidepressant, inhibits the mitochondrial oxidation of fatty acids and produces microvesicular steatosis of the liver in mice. J Pharmacol Exp Ther 247 (1988) 745-750
25. Fromenty B., Freneaux E., Labbe G., et al. Tianeptine, a new tricyclic antidepressant metabolised by beta-oxidation of its heptanoic side chain, inhibits the mitochondrial oxidation of medium and short chain fatty acids in mice. Biochem Pharmacol 38 (1989) 3743-3751
26. Weinbach E.C., Costa J.L., Nelson B.D., et al. Effects of tricyclic antidepressant drugs on energy-linked reactions in the mitochondria. Biochem Pharmacol 35 (1986) 1445-1451
27. Heard K., Cain B.S., Dart R.C., et al. Tricyclic antidepressants directly depress human myocardial mechanical function independent of effects on the conduction system. Acad Emerg Med 8 (2001) 1122-1127
28. Kline J.A., Raymond R.M., Leonova E.D., et al. Insulin improves heart function and metabolism during non-ischaemic cardiogenic shock in awake canines. Cardiovasc Res 34 (1997) 289-298
29. Chelly J.E., Oguchi T., Liang Y.Y., et al. Role of the intra lipid solvent in the propofol-induced nitric oxide stimulation. [abstract]. Anesthesiology 85 (1996) A555