Two-layered dissolving microneedles formulated with intermediate-acting insulin

International Journal of Pharmaceutics

Volumn 436, Issue 1-2, 2012, Pages 387-393

  Ito, Yukako ^a   Hirono, Muneyuki ^a   Fukushima, Keizo ^b   Sugioka, Nobuyuki ^b   Takada, Kanji ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

Dissolving microneedles; Insulin analog; Protamine sulfate insulin; Rats; Relative pharmacological availability; Transdermal delivery; Two layered

Indexed keywords

GLUCOSE; INSULIN; ISOPHANE INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DISSOLVING MICRONEEDLE; DRUG DELIVERY SYSTEM; GLUCOSE BLOOD LEVEL; HYPOGLYCEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TEMPERATURE;

ANIMALS; BLOOD GLUCOSE; HYPOGLYCEMIC AGENTS; INJECTIONS, SUBCUTANEOUS; INSULIN; MALE; MICROINJECTIONS; NEEDLES; RATS; RATS, WISTAR; SKIN;

EID: 84865306956     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.06.047     Document Type: Article

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