Design and physicochemical characterisation of novel dissolving polymeric microneedle arrays for transdermal delivery of high dose, low molecular weight drugs

Journal of Controlled Release

Volumn 180, Issue 1, 2014, Pages 71-80

  McCrudden, Maelíosa T C ^a   Alkilani, Ahlam Zaid ^a,b   McCrudden, Cian M ^a   McAlister, Emma ^a   McCarthy, Helen O ^a   Woolfson, A David ^a   Donnelly, Ryan F ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b ZARQA UNIVERSITY   (Jordan)

Author keywords

Biocompatibility; Ibuprofen; Microneedles; Transdermal

Indexed keywords

BIOCOMPATIBILITY; DISSOLUTION; ELECTROPHORESIS; ELECTROTHERAPEUTICS; MOLECULAR WEIGHT; NEEDLES; POLYMERS; RATS; SODIUM;

HUMAN THERAPEUTICS; IBUPROFEN; LOW MOLECULAR WEIGHT; LOW MOLECULAR WEIGHT DRUGS; MICRONEEDLE ARRAYS; MICRONEEDLES; TRANSDERMAL; TRANSDERMAL DELIVERY;

DRUG DOSAGE;

COPOLYMER; DODECYL SULFATE SODIUM; IBUPROFEN; INTERLEUKIN 1ALPHA; MALEIC ACID; POLY(METHYLVINYLETHER CO MALEIC ACID); UNCLASSIFIED DRUG; DRUG; NONSTEROID ANTIINFLAMMATORY AGENT; POLYMER;

ANIMAL EXPERIMENT; ARTICLE; BIOCOMPATIBILITY; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; DISSOLUTION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; IONTOPHORESIS; MALE; MICRONEEDLE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; SKIN PENETRATION; WATER CONTENT; ANIMAL; CELL LINE; CHEMISTRY; DEVICES; EQUIPMENT DESIGN; HUMAN; INTRADERMAL DRUG ADMINISTRATION; METABOLISM; MICROINJECTION; MOLECULAR WEIGHT; NEEDLE; SKIN; SKIN ABSORPTION; SOLUBILITY; SPRAGUE DAWLEY RAT; SWINE;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; HUMANS; IBUPROFEN; MALE; MICROINJECTIONS; MOLECULAR WEIGHT; NEEDLES; PHARMACEUTICAL PREPARATIONS; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SKIN; SKIN ABSORPTION; SOLUBILITY; SWINE;

EID: 84895558909     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.02.007     Document Type: Article

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