Increased spinal cord Na+-K+-2Cl- cotransporter-1 (NKCC1) activity contributes to impairment of synaptic inhibition in paclitaxel-induced neuropathic pain

Journal of Biological Chemistry

Volumn 289, Issue 45, 2014, Pages 31111-31120

  Chen, Shao Rui ^a   Zhu, Lihong ^a   Chen, Hong ^a   Wen, Lei ^a   Laumet, Geoffroy ^a   Pan, Hui Lin ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROPATHIC PAIN; PACLITAXEL; SPINAL CORDS;

4 AMINOBUTYRIC ACID; AMPA RECEPTOR; BETA ACTIN; BETA TUBULIN; BUMETANIDE; GLUTAMIC ACID; KINESIN 5; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PACLITAXEL; POTASSIUM CHLORIDE COTRANSPORTER 2; SODIUM POTASSIUM CHLORIDE COTRANSPORTER 1; KIF5B PROTEIN, RAT; KINESIN; SLC12A2 PROTEIN, RAT; TUBULIN MODULATOR;

ADULT; ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GABAERGIC SYSTEM; HYPERALGESIA; HYPERPOLARIZATION; MALE; MEMBRANE DEPOLARIZATION; MICROTUBULE ASSEMBLY; MOLECULAR PATHOLOGY; MUSCLE SPINDLE AFFERENT NERVE; NERVE CELL PLASTICITY; NERVE POTENTIAL; NEUROPATHIC PAIN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; SPINAL CORD DORSAL HORN; SYNAPTIC INHIBITION; SYSTEMIC THERAPY; TISSUE LEVEL; ANIMAL; CELL MEMBRANE; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; ELECTROPHYSIOLOGY; ENDOSOME; HOMEOSTASIS; METABOLISM; MICROTUBULE; NEURALGIA; NOCICEPTION; SPINAL CORD; SPRAGUE DAWLEY RAT; SYNAPSE;

ANIMALS; CELL MEMBRANE; ELECTROPHYSIOLOGY; ENDOSOMES; HOMEOSTASIS; KINESIN; MALE; MICROTUBULES; NEURALGIA; NEURONAL PLASTICITY; NOCICEPTION; PACLITAXEL; RATS; RATS, SPRAGUE-DAWLEY; SOLUTE CARRIER FAMILY 12, MEMBER 2; SPINAL CORD; SYNAPSES; TUBULIN MODULATORS;

EID: 84909957842     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.600320     Document Type: Article

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