Chronic opioid potentiates presynaptic but impairs postsynaptic N-methyl-D-aspartic acid receptor activity in spinal cords: Implications for opioid hyperalgesia and tolerance

Journal of Biological Chemistry

Volumn 287, Issue 30, 2012, Pages 25073-25085

  Zhao, Yi Lin ^a,c   Chen, Shao Rui ^a   Chen, Hong ^a   Pan, Hui Lin ^a,b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACID RECEPTORS; CLINICAL EFFICACY; HYPERALGESIA; INTRATHECAL; NMDA RECEPTOR; OPIOIDS; PRE-TREATMENT; PRESYNAPTIC; RAT SPINAL CORD; RESINIFERATOXIN; SPINAL CORDS; VOLTAGE CLAMP; WHOLE CELL;

AMINO ACIDS;

ACTIVATION ANALYSIS;

CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUTAMIC ACID; MORPHINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; PROTEIN KINASE C; RESINIFERATOXIN; VANILLOID RECEPTOR 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; HYPERALGESIA; MALE; MORPHINE TOLERANCE; NOCICEPTION; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; SPINAL CORD; SPINAL CORD DORSAL HORN; THERMAL STIMULATION; VOLTAGE CLAMP;

ANALGESICS, OPIOID; ANIMALS; HYPERALGESIA; INJECTIONS, SPINAL; MALE; MORPHINE; POSTERIOR HORN CELLS; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; TRPV CATION CHANNELS;

NEPTUNIA; RATTUS;

EID: 84864108171     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.378737     Document Type: Article

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