Role of protein kinase Cε and protein kinase A in a model of paclitaxel-induced painful peripheral neuropathy in the rat

Neuroscience

Volumn 108, Issue 3, 2001, Pages 507-515

  Dina, O A ^a   Chen, X ^a   Reichling, D ^a   Levine, J D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Electrophysiology; Mechanical hyperalgesia; Neuropathic pain; Signaling mechanisms; Taxol

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; PACLITAXEL; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMOTHERAPY; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; EVOKED SOMATOSENSORY RESPONSE; EXPERIMENTAL MODEL; HYPERALGESIA; INFLAMMATION; MALE; NERVE FIBER; NERVE STIMULATION; NEUROPATHY; NOCICEPTION; NONHUMAN; PAIN THRESHOLD; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; RAT; SECOND MESSENGER;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HEAT; HYPERALGESIA; ISOENZYMES; MALE; NERVE FIBERS; NOCICEPTORS; PACLITAXEL; PAIN THRESHOLD; PERIPHERAL NERVOUS SYSTEM DISEASES; PHYSICAL STIMULATION; PROTEIN KINASE C; PROTEIN KINASE C-EPSILON; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0035910168     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(01)00425-0     Document Type: Article

References (67)

1. Taxol: A history of pharmaceutical development and current pharmaceutical concerns
2. Protein kinase C inhibitors decrease hyperalgesia and C-fiber hyperexcitability in the streptozotocin-diabetic rat
3. Vincristine hyperalgesia in the rat: A model of painful vincristine neuropathy in humans
4. Nerve growth factor prevents toxic neuropathy in mice
5. How does taxol stabilize microtubules?
6. Pain related behaviour during vincristine-induced neuropathy in rats
7. Assessment of allodynia and hyperalgesia after cisplatin administration to rats
8. Description of a short-term Taxol-induced nociceptive neuropathy in rats
9. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
10. Peripheral neurotoxicity of taxol in patients previously treated with cisplatin
11. Effect on the peripheral nervous system of the short-term intravenous administration of paclitaxel in the rat
12. Distribution of paclitaxel within the nervous system of the rat after repeated intravenous administration
13. Experimental peripheral neuropathy induced in adult rats by repeated intraperitoneal administration of taxol
14. Quantitative assessment of tactile allodynia in the rat paw
15. Peripheral neuropathy from Taxol and cisplatin combination chemotherapy: Clinical and electrophysiological studies
16. Taxol (paclitaxel), first molecule of a new class of cytotoxic agents: Taxanes
17. Hyper-responsivity in a subset of C-fiber nociceptors in a model of painful diabetic neuropathy in the rat
18. Role of cyclic AMP receptor proteins in growth, differentiation, and suppression of malignancy: New approaches to therapy
19. Physiological characterization of Taxol-induced large-fiber sensory neuropathy in the rat
20. Taxol induces the assembly of free microtubules in living cells and blocks the organizing capacity of the centrosomes and kinetochores
21. Key role for the epsilon isoform of protein kinase C in painful alcoholic neuropathy in the rat
22. Prospective study of paclitaxel-induced peripheral neuropathy with quantitative sensory testing
23. The ACTH-(4-9) analog, ORG 2766, prevents taxol-induced neuropathy in rats
24. Electrophysiological mechanisms in inflammatory pain
25. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
26. The electrophysiological identification of single nerve fibers, with particular reference to the slowest-conduction vagal afferent fibers in the cat
27. Reversible peripheral neuropathy induced by a single administration of high-dose paclitaxel
28. Involvement of protein kinase C during taxol-induced activation of murine peritoneal macrophages
29. A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice
30. Differential localization of protein kinase C isozymes in U937 cells: Evidence for distinct isozyme functions during monocyte differentiation
31. Involvement of the sympathetic postganglionic neuron in capsaicin-induced secondary hyperalgesia in the rat
32. Taxol produces a predominantly sensory neuropathy
33. Linking protein kinase C to cell-cycle control
34. Possible drug-associated pancreatitis after paclitaxel-cremophor administration
35. Schedule dependency of paclitaxel-induced neuropathy in mice: A morphological study
36. The role of protein kinase C isoforms in cell proliferation and apoptosis
37. PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18
38. Paclitaxel-induced neuropathy
39. Pharmacological action of paclitaxel
40. A method for measurement of analgesic activity on inflammed tissue
41. Clinical pharmacology of Taxol
42. Update on the antitumor activity of paclitaxel in clinical trials
43. Neurotoxicity of Taxol
44. Phase I and pharmacologic study of paclitaxel and cisplatin with granulocyte colony-stimulating factor: Neuromuscular toxicity is dose-limiting
45. Clinical toxicities encountered with paclitaxel (Taxol)
46. Neuropathic pain
47. Taxol stabilizes microtubules in mouse fibroblast cells
48. Single-agent paclitaxel in the treatment of advanced non-small cell lung cancer
49. PKC-epsilon regulates basolateral endocytosis in human T84 intestinal epithelia: Role of F-actin and MARCKS
50. Neuropathic pain in aged rats: Behavioral responses and astrocytic activation
51. Associations of PKC isoforms with the cytoskeleton of B16F10 melanoma cells
52. The contribution of training to sensitivity in the nociceptive paw-withdrawal test
53. Contribution of guanine nucleotide regulatory proteins to prostaglandin hyperalgesia in the rat
54. Microtubule disorientation and axonal swelling in unmyelinated sensory axons during vincristine-induced painful neuropathy in rat
55. Nociceptor hyper-responsiveness during vincristine-induced painful peripheral neuropathy in the rat
56. Damage to the cytoskeleton of large diameter sensory neurons and myelinated axons in vincristine-induced painful peripheral neuropathy in the rat
57. Mechanisms of Taxol-induced cell death are concentration dependent
58. Synergistic inhibition of human cancer cell growth by cytotoxic drugs and mixed backbone antisense oligonucleotide targeting protein kinase A
59. Cooperative inhibitory effect of novel mixed backbone oligonucleotide targeting protein kinase A in combination with docetaxel and anti-epidermal growth factor-receptor antibody on human breast cancer cell growth
60. Taxanes: An overview of the pharmacokinetics and pharmacodynamics
61. Paclitaxel (Taxol) induces cumulative mild neurotoxicity
62. The long-term effects of a single injection of taxol upon peripheral nerve axons
63. Effect of bryostatin 1 on taxol-induced apoptosis and cytotoxicity in human leukemia cells (U937)
64. Neurotoxicity of commonly used antineoplastic agents (first of two parts)
65. Phase I trial of taxol given as a 24-hour infusion every 21 days: Responses observed in metastatic melanoma
66. The pain system. The neural basis of nociceptive transmission in the mammalian nervous system
67. Involvement of protein kinase C in taxol-induced polyploidization in a cultured sarcoma cell line