Role of presynaptic muscarinic and GABAB receptors in spinal glutamate release and cholinergic analgesia in rats

Journal of Physiology

Volumn 543, Issue 3, 2002, Pages 807-818

  Li, De Pei ^a   Chen, Shao Rui ^a   Pan, Yu Zhen ^a   Levey, Allan I ^b   Pan, Hui Lin ^a,c  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; ACETYLCHOLINE; ATROPINE; BENZYL[3 [[1 (3,4 DICHLOROPHENYL)ETHYL]AMINO] 2 HYDROXYPROPYL]PHOSPHINIC ACID; CHOLINERGIC RECEPTOR STIMULATING AGENT; CHOLINESTERASE INHIBITOR; CPG 55845; GLUTAMIC ACID; MECAMYLAMINE; MUSCARINE; MUSCARINIC AGENT; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; TETRODOTOXIN; MUSCARINIC M2 RECEPTOR;

ANALGESIC ACTIVITY; ANIMAL TISSUE; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; DORSAL RHIZOTOMY; DORSAL ROOT POTENTIAL; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; ELECTROSTIMULATION; EXCITATORY POSTSYNAPTIC POTENTIAL; IMMUNOHISTOCHEMISTRY; INHIBITORY POSTSYNAPTIC POTENTIAL; MINIATURE ENDPLATE POTENTIAL; MONOSYNAPTIC POTENTIAL; NOCICEPTION; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; RAT; REVIEW; SPINAL ANESTHESIA; SPINAL CORD DORSAL HORN; SYNAPTIC INHIBITION; TISSUE SLICE; VOLTAGE CLAMP; ADULT; AMINO ACID SYNTHESIS; AMPLITUDE MODULATION; ANIMAL CELL; ANTINOCICEPTION; ARTICLE; CHOLINERGIC SYNAPSE; FREQUENCY MODULATION; GLUTAMATERGIC SYNAPSE; IMMUNOREACTIVITY; IN VITRO STUDY; MUSCLE SPINDLE AFFERENT NERVE; PRESYNAPTIC POTENTIAL; PROTEIN FUNCTION;

ACETYLCHOLINE; ANALGESIA; ANIMALS; EXCITATORY POSTSYNAPTIC POTENTIALS; GLUTAMIC ACID; NOCICEPTORS; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MUSCARINIC M2; RECEPTORS, GABA-B; RECEPTORS, MUSCARINIC; RECEPTORS, PRESYNAPTIC;

EID: 0037106432     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2002.020644     Document Type: Review

References (38)

1. Baba, H., Kohno, T., Okamoto, M., Goldstein, P. A., Shimoji, K. & Yoshimura, M. (1998). Muscarinic facilitation of GABA release in substantia gelatinosa of the rat spinal dorsal horn. Journal of Physiology 508, 83-93.
2. Chen, S.-R., Eisenach, J. C., McCaslin, P. P. & Pan, H.-L. (2000). Synergistic effect between intrathecal non-NMDA antagonist and gabapentin on allodynia induced by spinal nerve ligation in rats. Anesthesiology 92, 500-506.
3. Chen, S. R. & Pan, H. L. (2001). Spinal endogenous acetylcholine contributes to the analgesic effect of systemic morphine in rats. Anesthesiology 95, 525-530.
4. B receptors are the first target of released GABA at lamina I inhibitory synapses in the adult rat spinal cord. Journal of Neurophysiology 84, 1006-1011.
5. B and adenosine receptor activation. Neuroscience Letters 247, 183-186.
6. De Biasi, S. & Rustioni, A. (1988). Glutamate and substance P coexist in primary afferent terminals in the superficial laminae of spinal cord. Proceedings of the National Academy of Sciences of the USA 85, 7820-7824.
7. Gomeza, J., Shannon, H., Kostenis, E., Felder, C., Zhang, L., Brodkin, J., Grinberg, A., Sheng, H. & Wess, J. (1999). Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice. Proceedings of the National Academy of Sciences of the USA 96, 1692-1697.
8. Haberberger, R., Henrich, M., Couraud, J. Y. & Kummer, W. (1999). Muscarinic M2-receptors in rat thoracic dorsal root ganglia. Neuroscience Letters 266, 177-180.
9. Headley, P. M. & Grillner, S. (1990). Excitatory amino acids and synaptic transmission: the evidence for a physiological function. Trends in Pharmacological Sciences 11, 205-211.
10. Hoglund, A. U. & Baghdoyan, H. A. (1997). M2, M3 and M4, but not M1, muscarinic receptor subtypes are present in rat spinal cord. Journal of Pharmacology and Experimental Therapeutics 281, 470-477.
11. Hood, D. D., Mallak, K. A., James, R. L., Tuttle, R. & Eisenach, J. C. (1997). Enhancement of analgesia from systemic opioid in humans by spinal cholinesterase inhibition. Journal of Pharmacology and Experimental Therapeutics 282, 86-92.
12. Hulme, E. C., Birdsall, N. J. & Buckley, N. J. (1990). Muscarinic receptor subtypes. Annual Review of Pharmacology and Toxicology 30, 633-673.
13. Isaacson, J. S., Solis, J. M. & Nicoll, R. A. (1993). Local and diffuse synaptic actions of GABA in the hippocampus. Neuron 10, 165-175.
14. Iwamoto, E. T. & Marion, L. (1993). Characterization of the antinociception produced by intrathecally administered muscarinic agonists in rats. Journal of Pharmacology and Experimental Therapeutics 266, 329-338.
15. Iyadomi, M., Iyadomi, I., Kumamoto, E., Tomokuni, K. & Yoshimura, M. (2000). Presynaptic inhibition by baclofen of miniature EPSCs and IPSCs in substantia gelatinosa neurons of the adult rat spinal dorsal horn. Pain 85, 385-393.
16. Kohno, T., Kumamoto, E., Higashi, H., Shimoji, K. & Yoshimura, M. (1999). Actions of opioids on excitatory and inhibitory transmission in substantia gelatinosa of adult rat spinal cord. Journal of Physiology 518, 803-813.
17. Lekan, H. A., & Carlton, S. M. (1995). Glutamatergic and GABAergic input to rat spinothalamic tract cells in the superficial dorsal horn. Journal of Comparative Neurology 361, 417-428.
18. Levey, A. I., Edmunds, S. M., Koliatsos, V., Wiley, R. G. & Heilman, C. J. (1995). Expression of m1-m4 muscarinic acetylcholine receptor proteins in rat hippocampus and regulation by cholinergic innervation. Journal of Neuroscience 15, 4077-4092.
19. Li, D.-P. & Pan, H.-L. (2001). Potentiation of glutamatergic synaptic input to supraoptic neurons by presynaptic nicotinic receptors. American Journal of Physiology 281, R1105-1113.
20. Naguib, M. & Yaksh, T. L. (1994). Antinociceptive effects of spinal cholinesterase inhibition and isobolographic analysis of the interaction with mu and alpha2 receptor systems. Anesthesiology 80, 1338-1348.
21. Okamoto, M., Baba, H., Goldstein, P. A., Higashi, H., Shimoji, K. & Yoshimura, M. (2001). Functional reorganization of sensory pathways in the rat spinal dorsal horn following peripheral nerve injury. Journal of Physiology 532, 241-250.
22. Ossipov, M. H., Bian, D., Malan, T. P. Jr, Lai, J. & Porreca, F. (1999). Lack of involvement of capsaicin-sensitive primary afferents in nerve-ligation injury induced tactile allodynia in rats. Pain 79, 127-133.
23. Pan, Y.-Z., Li, D.-P. & Pan, H.-L. (2002). Inhibition of glutamatergic synaptic input to spinal lamina IIo neurons by presynaptic alpha2-adrenergic receptors. Journal of Neurophysiology 87, 1938-1947.
24. Price, G. W., Wilkin, G. P., Turnbull, M. J. & Bowery, N. G. (1984). Are baclofen-sensitive GABAB receptors present on primary afferent terminals of the spinal cord? Nature 307, 71-74.
25. Redman, S. (1990). Quantal analysis of synaptic potentials in neurons of the central nervous system. Physiological Reviews 70, 165-198.
26. Ribeiro-da-Silva, A. & Cuello, A. C. (1990). Choline acetyltransferase-immunoreactive profiles are presynaptic to primary sensory fibers in the rat superficial dorsal horn. Journal of Comparative Neurology 295, 370-384.
27. A receptor activation. Neuroscience 103, 725-737.
28. Tata, A. M., Vilaro, M. T., Agrati, C., Biagioni, S., Mengod, G. & Augusti-Tocco, G. (1999). Expression of muscarinic m2 receptor mRNA in dorsal root ganglia of neonatal rat. Brain Research 824, 63-70.
29. Todd, A. J. & Lochhead, V. (1990). GABA-like immunoreactivity in type I glomeruli of rat substantia gelatinosa. Brain Research 514, 171-174.
30. B receptor protein and mRNA distribution in rat spinal cord and dorsal root ganglia. European Journal of Neuroscience 12, 3201-3210.
31. Waldvogel, H. J., Faull, R. L., Jansen, K. L., Dragunow, M., Richards, J. G., Mohler, H. & Streit, P. (1990). GABA, GABA receptors and benzodiazepine receptors in the human spinal cord: an autoradiographic and immunohistochemical study at the light and electron microscopic levels. Neuroscience 39, 361-385.
32. Wess, J. (1996). Molecular biology of muscarinic acetylcholine receptors. Critical Reviews in Neurobiology 10, 69-99.
33. Wetts, R. & Vaughn, J. E. (1994). Choline acetyltransferase and NADPH diaphorase are co-expressed in rat spinal cord neurons. Neuroscience 63, 1117-1124.
34. Woodbury, C. J., Ritter, A. M. & Koerber, H. R. (2000). On the problem of lamination in the superficial dorsal horn of mammals: a reappraisal of the substantia gelatinosa in postnatal life. Journal of Comparative Neurology 417, 88-102.
35. Yoon, K. W. & Rothman, S. M. (1991). The modulation of rat hippocampal synaptic conductances by baclofen and γ-aminobutyric acid. Journal of Physiology 442, 377-390.
36. Yoshimura, M. & Jessell, T. (1990). Amino acid-mediated EPSPs at primary afferent synapses with substantia gelatinosa neurones in the rat spinal cord. Journal of Physiology 430, 315-335.
37. Yoshimura, M. & Nishi, S. (1993). Blind patch-clamp recordings from substantia gelatinosa neurons in adult rat spinal cord slices: pharmacological properties of synaptic currents. Neuroscience 53, 519-526.
38. Yung, K. K. & Lo, Y. L. (1997). Immunocytochemical localization of muscarinic m2 receptor in the rat spinal cord. Neuroscience Letters 229, 81-84.